Induction of Transient Cell Proliferation by Manufactured Gas Plant Residue in B6C3F<sub>1</sub>Male Mice

Dunsford, Harold A.; Zhu, Lunjian; Chaloupka, K.; Steinberg, Michael A.; Safe, Stephen; Womack, James E.; Goldstein, Lawrence S.B.; Rodriguez, Lewis V.

doi:10.1080/10406639408014728

Polycyclic Aromatic Compounds

1994

DOI: 10.1080/10406639408014728

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Induction of Transient Cell Proliferation by Manufactured Gas Plant Residue in B6C3F₁Male Mice

Harold A. Dunsford

Lunjian Zhu

K. Chaloupka³

et al.

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1996

1997

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Cited by 2 publications

References 13 publications

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EMF and current cancer concepts

Kavet

1996

Bioelectromagnetics

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Exposure to power frequency electric and magnetic fields (EMF) is ubiquitous, and a body of epidemiologic studies has produced evidence suggestive of a possible link between EMF exposure and cancer of several types. This paper provides a perspective that holds key findings in the EMF literature against the background of important models and established principles in cancer biology. It is intended primarily for scientists whose expertise lies outside of cancer biology and animal bioassays. Current thinking holds that carcinogenesis is a multistep process that requires at least two genotoxic events in its critical path but that is facilitated by nongenotoxic proliferative effects on target cells. EMF, which itself is not believed to be genotoxic, could influence carcinogenesis if it exerted either direct or indirect effects on target cell turnover. Such effects could operate through receptor‐mediated or nonreceptor‐mediated pathways. However, effects relevant to carcinogenesis have not been confirmed, and a mode of action for EMF has not been determined. Chronic bioassays in rodents are in progress to examine the potential carcinogenicity of EMFs. EMF research has the opportunity to capitalize on the recent major advances in our understanding of carcinogenic processes. © 1996 Wiley‐Liss, Inc.

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EMF and current cancer concepts

Kavet

1996

Bioelectromagnetics

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Carcinogenicity of benzo[a]pyrene and manufactured gas plant residues in infant mice

Rodriguez¹

1997

Carcinogenesis

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The present study determined tumorigenicity, tumor classification and DNA damage induced in infant mice by benzo[a]pyrene (B[a]P) or Manufactured Gas Plant (MGP) residues after a single exposure. Male and female B6C3F1 mice were exposed to B[a]P or MGP residue from a single environmental site (MGP-4) and males were also exposed to MGP residue composite from seven different sites (MGP-M7). At 26, 39 and 52 weeks after exposure tumorigenesis was assessed in lung, forestomach and liver. Formation and persistence of DNA adducts were quantified by 32P-postlabeling. Exposure of males to B[a]P induced liver tumors in a dose and time dependent manner. MGP induced more advanced tumors than B[a]P. Only a single liver tumor was found in MGP-4 treated females. No forestomach and few pulmonary adenomas were induced in males or females. MGP-4, MGP-M7 or B[a]P induced DNA adducts in males and females. Adducts in liver, lung and forestomach peaked on different days and decreased at different rates. At 24 h post-exposure, no significant differences in initial DNA adduct levels occurred in males and females exposed to MGP-4 or B[a]P. Lack of DNA damage (adducted DNA) did not account for non-responsiveness of lung and forestomach in B6C3F1 genders as well as in liver in females. MGP tumorigenicity could not be accounted for solely by B[a]P content nor did it reflect additivity of B[a]P and other carcinogenic polycyclic aromatic hydrocarbons (PAHs) in MGP. Synergy among MGP-PAHs, presence of unidentified carcinogens and/or promoters in MGP may account for MGP potency. The B6C3F1 infant male model is a convenient and rapid assay for assessing MGP liver tumorigenicity and potency.

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Induction of Transient Cell Proliferation by Manufactured Gas Plant Residue in B6C3F₁Male Mice

Cited by 2 publications

References 13 publications

EMF and current cancer concepts

EMF and current cancer concepts

Carcinogenicity of benzo[a]pyrene and manufactured gas plant residues in infant mice

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Induction of Transient Cell Proliferation by Manufactured Gas Plant Residue in B6C3F1Male Mice

Cited by 2 publications

References 13 publications

EMF and current cancer concepts

EMF and current cancer concepts

Carcinogenicity of benzo[a]pyrene and manufactured gas plant residues in infant mice

Contact Info

Product

Resources

About

Induction of Transient Cell Proliferation by Manufactured Gas Plant Residue in B6C3F₁Male Mice