Induction of telomerase activity increase reprogramming efficiency of human dermal fibroblasts

Дашинимаев, Э. Б.; Muchkaeva, I. A.; Файзуллин, Р. Р.; Yegorov, Y. Y.; Akimov, Sergey; Terskikh, V. V.; Vasiliev, A. V.; Kirpichnikov, Mikhaǐl P.

doi:10.3103/s0096392512010038

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…61 Moreover, upregulation of pluripotency genes is strongly connected with expression of TERT, the overexpression of which enhances reprogramming efficiency. 62,63 For example, porcine iPSCs can only maintain telomeres with continued expression of exogenous reprogramming factors to maintain TERT levels, 31 and partially reprogrammed mouse embryonic fibroblasts (MEFs), and porcine embryonic fibroblasts (PEFs) show little TERT promoter activation and poor telomere elongation. However, while low telomerase activity is correlated with partial reprogramming, high levels of TERT alone does not induce a pluripotent state, 48 nor does pluripotency strictly require high levels of TERT.…”

Section: Pluripotency and Canonical Tert Functionsmentioning

confidence: 99%

The role of telomeres and telomerase reverse transcriptase isoforms in pluripotency induction and maintenance

2016

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Telomeres are linear guanine-rich DNA structures at the ends of chromosomes. The length of telomeric DNA is actively regulated by a number of mechanisms in highly proliferative cells such as germ cells, cancer cells, and pluripotent stem cells. Telomeric DNA is synthesized by way of the ribonucleoprotein called telomerase containing a reverse transcriptase (TERT) subunit and RNA component (TERC). TERT is highly conserved across species and ubiquitously present in their respective pluripotent cells. Recent studies have uncovered intricate associations between telomeres and the self-renewal and differentiation properties of pluripotent stem cells. Interestingly, the past decade's work indicates that the TERT subunit also has the capacity to modulate mitochondrial function, to remodel chromatin structure, and to participate in key signaling pathways such as the Wnt/b-catenin pathway. Many of these non-canonical functions do not require TERT's catalytic activity, which hints at possible functions for the extensive number of alternatively spliced TERT isoforms that are highly expressed in pluripotent stem cells. In this review, some of the established and potential routes of pluripotency induction and maintenance are highlighted from the perspectives of telomere maintenance, known TERT isoform functions and their complex regulation.

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Section: Pluripotency and Canonical Tert Functionsmentioning

confidence: 99%

The role of telomeres and telomerase reverse transcriptase isoforms in pluripotency induction and maintenance

2016

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Moscow University Biological Sciences Bulletin—a new era of evolution (2007–2013)

Kirpichnikov

Хохлов

2014

Moscow Univ. Biol.Sci. Bull.

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The editorial board of MUBSB includes many well known scientists, among which there are seven full members and four corresponding members of the Russian Academy of Sciences. The editorial board is headed by a full member of the Russian Academy of Sciences, Dean of the School of Biology of Moscow State University M.P. Kirpichnikov.Owing to its specificity, MUBSB is a multidisci plinary edition; therefore, it publishes the works devoted to numerous aspects of both theoretical and experimental biology, which makes it interesting for scientists who belong to the most varied branches of biological science. In particular, papers touch upon the problems of ecology, biomedicine, botany, zool ogy, molecular biology, embryology, plant and animal physiology, biochemistry, biophysics, genetics, cytol ogy, virology, immunology, microbiology, gerontology, evolutionary biology, biotechnology, bioengineering, etc.The journal publishes approximately 40 papers per year in total (four quarterly issues).MUBSB is indexed in many international data bases: Google Scholar, CAB International, Academic OneFile, CAB Abstracts, Gale, Global Health, Health Reference Center Academic, OCLC, and Summon by Serial Solutions.Since 2011, MUBSB is also present in one of the most well known databases of this type-Scopus. This electronic resource contains both separate papers from the journal and its own page with all scientomet ric indices [1]. MUBSB also has its own page on the The rapid progress of MUBSB in recent years is apparently due to the journal having been distributed since 2007 by the internationally renowned Springer publishing consortium that places electronic versions of all articles on its website, which has, to all appearances, led to a manifold increase in the number of journal subscribers. As a result, the number of downloads of MUBSB papers from the publishing company website also raised by an order of magnitude from 2007 to 2013. The growing popularity of the journal is noted to have lead to its inclusion in a number of international databases, and this, in turn, has increased its attractiveness for a large number of authors, including Russian nonmem bers of Moscow State University, as well as scientists from research institutes and universities of other coun tries. The main features of the spectrum of the papers published in MUBSB are briefly considered. EDITORIAL Moscow University Biological Sciences

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Induction of telomerase activity increase reprogramming efficiency of human dermal fibroblasts

Cited by 2 publications

References 19 publications

The role of telomeres and telomerase reverse transcriptase isoforms in pluripotency induction and maintenance

The role of telomeres and telomerase reverse transcriptase isoforms in pluripotency induction and maintenance

Moscow University Biological Sciences Bulletin—a new era of evolution (2007–2013)

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