2002
DOI: 10.1016/s0304-3835(02)00320-8
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Induction of telomerase activity during an early burst of proliferation in pancreatic regeneration

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Cited by 6 publications
(4 citation statements)
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“…embryo, testis (Martin-Rivera et al, 1998;Greenberg et al, 1998;Hiyama and Hiyama, 2003;Park et al, 2004;Pannone et al, 2007;Herbert et al, 2007). In vivo studies using non-tumor tissues further revealed a good correlation between TA, cell proliferation and apoptosis (Inui et al, 2002;Oh et al, 2002;Lamy et al, 2013). The anti-apoptotic function of telomerase was first reported by Kondo et al (1998), showing that inhibition of hTERT by anti-sense RNA significantly reduced TA in glioblastoma cells and, at the same time, increased cell susceptibility to cisplatin-induced apoptosis.…”
Section: Introductionmentioning
confidence: 92%
“…embryo, testis (Martin-Rivera et al, 1998;Greenberg et al, 1998;Hiyama and Hiyama, 2003;Park et al, 2004;Pannone et al, 2007;Herbert et al, 2007). In vivo studies using non-tumor tissues further revealed a good correlation between TA, cell proliferation and apoptosis (Inui et al, 2002;Oh et al, 2002;Lamy et al, 2013). The anti-apoptotic function of telomerase was first reported by Kondo et al (1998), showing that inhibition of hTERT by anti-sense RNA significantly reduced TA in glioblastoma cells and, at the same time, increased cell susceptibility to cisplatin-induced apoptosis.…”
Section: Introductionmentioning
confidence: 92%
“…The cDNA synthesis was done as previously described. 31 The total RNA (2 g) was pretreated with RNase-free DNase I (Takara, Shiga, Japan) for 20 minutes at 37°C to remove genomic DNA before the cDNA synthesis. The complete removal of the genomic DNA was confirmed by a PCR of the total RNA using ␤-actin primers, which generated no product.…”
Section: Isolation Of Total Rna and Synthesis Of Cdnamentioning
confidence: 99%
“…Three weeks after 90% PX, the pancreatic insulin content of the remnant pancreas is doubled [18]. Here, β‐cell mass expansion has been attributed to neogenesis because there is a wave of proliferation initiated in main ducts, which is followed in smaller ducts, and finally in islet β‐cells [18–20]. In favour of this view is the transient upregulation of pdx1 expression in ductal cells [21], and the fact that β‐cell regeneration is unaffected in animals initially β‐cell‐depleted with Streptozotocin (STZ) treatment, prior to 90% PX [22].…”
Section: Experimental Animal Models Of Induced or Inducible β‐Cell Mamentioning
confidence: 99%