Induction of T cell tolerance in agammaglobulinemic chickens

Rouse, Barry T.; Warner, Noel L.

doi:10.1002/eji.1830020120

Cited by 24 publications

(13 citation statements)

References 12 publications

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“…Our data suggest that light chains on T cells d o not exhibit antigenic determinants present on "free" light chains only, which is in agreement with observations of Lesley et al [35], Rouse and Warner [23] and Greaves [ 11. In contrast, other reports suggest that "free" light chain determinants are indeed present on lymphocytes [20,301.…”

Section: Discussionsupporting

confidence: 93%

“…sera interfered with neither the graft-versus-host reaction 120, 231 nor with some anti-p antisera, that contained anti-hinge region antibodies, blocked rosette formation of T cells collected from immunized mice [31,551. Several authors [47, [56][57][58] have failed to obtain any blocking effect of anti-Ig sera; this could be explained by the observation that not every ALCS exhibits blocking activity [23].…”

Section: Discussionmentioning

confidence: 99%

“…B cell functions were blocked by both anti-light chain and anti-heavy chain sera [ l , 2,14,18,19,27,31,32,371. Immune reactions mediated by T cells on the other hand, were inhibited by anti-light chain sera [20,23,30,351, but not by anti-p, y or a-chain sera [17,20,231. We have investigated the effect of anti-light and anti-heavy chain sera on human lymphocytes mediating migration inhibition.…”

Section: Introductionmentioning

confidence: 99%

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Effects of anti‐immunoglobulin sera on migration inhibition mediated by human lymphocytes

Marsman

Hart

1974

Eur J Immunol

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Effects of anti-immunoglobulin sera on migration inhibition mediated by human lymphocytes Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, AmsterdamMigration inhibition experiments were performed with mixtures of sensitized human lymphocytes and guinea pig peritoneal exudate cells. Treatment of human lymphocytes with a rabbit anti-human light chain serum (ALCS) abolished their capacity t o cause antigen-induced migration inhibition, whereas treatment with anti-heavy chain sera did not. The specificity of ALCS was confirmed by absorption studies. The finding that anti-heavy chain sera did not influence migration inhibition is consistent with other evidence that B cells are not directly involved in the migration inhibition process. The results provide indirect evidence that thepresumably thymus-dependentlymphocytes primarily involved in the migration inhibition process carry light chain determinants on their membrane.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of anti‐immunoglobulin sera on migration inhibition mediated by human lymphocytes

Marsman

Hart

1974

Eur J Immunol

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“…This interpretation is supported by the strong sensitivity of the thymic suppressor cells to x-irradiation, indicating that the cells must proliferate in order to mediate suppression. The specific suppressor cells are possibly analogous t o the suppressor cells in allograft-tolerant chickens [23] and to the antigenspecific thymus-dependent suppressor cells that have been found in mice in various expenmental situations [4-71. Thymus cells from third party donors are about as suppressive as cells from donors syngeneic t o the recipients, while thymus cells syngeneic to the graft donors were found t o be most effective. The latter mediate long-lasting skin graft survival across strong histocompatibility differences in 50-80 7-of the recipients.…”

Section: Discussionmentioning

confidence: 99%

The antigen‐inexperienced thymic suppressor cells: a class of lymphocytes in the young chicken thymus that inhibits antibody production and cell‐mediated immune responses

Droege¹

1976

Eur J Immunol

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Transfer of thymus cells from young chickens in combination with a light whole body irradiation (360 R) was found to suppress the rejection of skin grafts across strong histocompatibility (B) differences. On the average, the suppressed animals also showed decreased serum hemagglutinin titers against erythrocytes of the skin donor strain and a decreased graft-versus-host (GvH) reactivity against embryos of this strain. The thymic suppressor cells can be obtained from animals that have not experienced the antigen under test. However, after transfer and contact to the antigen (skin graft) they can lead to the formation of specific ("activated") suppressor cells and can mediate in the long run a specific inhibition of the response to this antigen. The suppressive activity is associated with a bursa-dependent cellular subpopulation in the thymus that is different from B lymphocytes, B precursor cells or GvH-reactive T cells. The bursa dependency of the thymic suppressor cell suggests that functionally different lineages of thymic and thymus-derived lymphocytes are derived from different sources of prethymic stem cells. The suppressor cells are predominantly found in the young chicken thymus and already detectable in the 16-day-old embryo, while poor suppressive activity is found in the adult thymus. The suppressive effect can be obtained with thymus cells from either syngeneic or allogeneic donors. Embryonic allogeneic donors provide suppressive cell preparations free of GvH reactivity. The possibility that the thymus suppressor cells mediate self tolerance and "neonatal tolerance" is discussed.

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“…Originally, it seemed logical to ascribe tolerance to an elimination of potentially self-reactive lymphocyte clones through early contact with antigen, a view that has subsequently received substantial (2, 3) but not unchallenged (4,5) experimental support. Since the discovery of suppressor T lymphocytes (6), it has been amply documented that these play a role in several different models oftolerance involving MHC antigens (7)(8)(9)(10)(11)(12)(13). Given that a lymphocyte population containing suppressor T cells may effectively inhibit the activation of normal immunocompetent cells ("infectious tolerance"), it becomes a matter of some difficulty to determine the presence or absence of functional T lymphocytes within a population whose phenotype is suppressor.…”

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confidence: 99%

Functional clonal deletion in immunological tolerance to major histocompatibility complex antigens.

Nossal¹,

Pike²

1981

Proc. Natl. Acad. Sci. U.S.A.

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CBA (H-2k) mice were rendered tolerant to H-2d antigens by injection of (CBA X BALB/c)F1 spleen cells at birth. At intervals of 2 days to 12 weeks, the frequencies of anti-H-2d cytotoxic T lymphocyte precursor cells (CTL-P) in thymus and spleen were determined by using a limiting-dilution microculture assay system for CTL-P. This assay, utilizing irradiated H-2d stimulator cells and concanavalin A-induced spleen cell conditioned medium, was shown to be linear over the range 30 to 100,000 responder cells and uninfluenced by IJ-positive cells. A profound and long-lasting deficit in activatable CTL-P, first demonstrable by day 5 of life in the thymus and day 8-10 in the spleen, developed in mice rendered tolerant, reaching a greater than 95% reduction by 6 weeks. Functional clonal deletion thus seems to be at least as important in the tolerant state as suppressor T cells. Repeated in vivo administration of anti-IJk serum partially inhibited clonal deletion, suggesting either that suppressor T cells are actively involved in producing clonal deletion or that IJk-bearing cells in the donor inoculum or the host represent an important factor.

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Induction of T cell tolerance in agammaglobulinemic chickens

Cited by 24 publications

References 12 publications

Effects of anti‐immunoglobulin sera on migration inhibition mediated by human lymphocytes

Effects of anti‐immunoglobulin sera on migration inhibition mediated by human lymphocytes

The antigen‐inexperienced thymic suppressor cells: a class of lymphocytes in the young chicken thymus that inhibits antibody production and cell‐mediated immune responses

Functional clonal deletion in immunological tolerance to major histocompatibility complex antigens.

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