Induction of systemic immunologic tolerance to β-lactoglobulin by oral administration of a whey protein hydrolysate

Fritsché, Rodolphe; Pahud, Jean Jacques; Pecquet, Sophie; Pfeifer, Andréa

doi:10.1016/s0091-6749(97)70235-5

Cited by 100 publications

(83 citation statements)

References 18 publications

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“…This suggests that specific peptides might contribute to hypoallergenic effects of hydrolysates. This has been confirmed in mouse models in which pre-treatment with partially hydrolyzed cow's milk proteins before sensitization induced oral tolerance and reduced allergic responses to whey protein [12,13]. This effect is associated with an increased percentage of regulatory T cells (Treg) in the mesenteric lymph nodes [13].…”

Section: Introductionmentioning

confidence: 81%

“…This has been confirmed in mouse models in which pre-treatment with partially hydrolyzed cow's milk proteins before sensitization induced oral tolerance and reduced allergic responses to whey protein [12,13]. This effect is associated with an increased percentage of regulatory T cells (Treg) in the mesenteric lymph nodes [13]. Transferring immune cells including Treg from tolerized mice protected recipients from developing an acute skin response after a challenge with whey [12,14].…”

Section: Introductionmentioning

confidence: 83%

“…However, most animal studies showing beneficial effects of hydrolysates in allergy mainly focus on immunoglobulin levels as a measure for sensitization [12,13,[30][31][32], while only a few studies investigated effects of whey hydrolysates on immune populations involved in the allergic response [12,14]. In this study, we investigated the effects of sensitization with a partially whey hydrolysate on allergy parameters and serum whey-specific IgE and IgG1 levels after an intradermal whey challenge.…”

Section: Discussionmentioning

confidence: 99%

“…Transferring immune cells including Treg from tolerized mice protected recipients from developing an acute skin response after a challenge with whey [12,14]. No oral tolerance was induced when pre-treatment was performed with proteins that were more extensively hydrolyzed [12,13].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Partially hydrolyzed whey proteins prevent clinical symptoms in a cow's milk allergy mouse model and enhance regulatory T and B cell frequencies

Kiewiet

Esch

Garssen

et al. 2017

Molecular Nutrition Food Res

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Scope:Partially hydrolyzed cow's milk proteins are used to prevent cow's milk allergy in children. Here we studied the immunomodulatory mechanisms of partial cow's milk hydrolysates in vivo. Methods and results: Mice were sensitized with whey or partially hydrolyzed whey using cholera toxin. Whey-specific IgE levels were measured to determine sensitization and immune cell populations from spleen, mesenteric lymph nodes and Peyer's patches after oral whey administration were measured by flowcytometry. Whey-specific IgE and IgG1 levels in partial whey hydrolysate sensitized animals were enhanced, but challenge did not induce clinical symptoms. This immunomodulatory effect of partial whey hydrolysate was associated with increased regulatory B and T cells in the spleen, together with a prevention of IgM-IgA class switching in the mesenteric lymph nodes and an increased Th1 and activated Th17 in the Peyer's patches. Conclusion: Partial hydrolysate sensitization did not induce whey-induced clinical symptoms, even though sensitization was established. Increased regulatory cell populations in the systemic immune system and a prevention of increased total Th1 and activated Th17 in the intestinal immune organs could contribute to the suppression of allergic symptoms. This knowledge is important for a better understanding of the beneficial effects of hydrolysates.

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Section: Introductionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Partially hydrolyzed whey proteins prevent clinical symptoms in a cow's milk allergy mouse model and enhance regulatory T and B cell frequencies

Kiewiet

Esch

Garssen

et al. 2017

Molecular Nutrition Food Res

View full text Add to dashboard Cite

show abstract

“…Previous studies of oral tolerance to BLG have been reported by oral administration of BLG, whey protein, whey hydrolysate formulas or milk powder. [14][15][16] However, there has been no investigation of the changes of antigen recognition sites on BLG at the induction of oral tolerance. We therefore tested that the eŠects of feeding a 0.3z and 3z BLG solution and milk on the antibody response to BLG and we then examined theˆne speciˆcity of BLG after feeding BLG and milk.…”

Section: Discussionmentioning

confidence: 99%

Induction of Oral Tolerance in Mice by Continuous Feeding with β-Lactoglobulin and Milk

Mizumachi

Kurisaki

2002

Bioscience, Biotechnology, and Biochemistry

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Peptide‐Based Immunotherapy for Food Allergy

Yang

Mine

2010

Bioactive Proteins and Peptides as Functional Foods and Nutraceuticals

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Induction of systemic immunologic tolerance to β-lactoglobulin by oral administration of a whey protein hydrolysate

Cited by 100 publications

References 18 publications

Partially hydrolyzed whey proteins prevent clinical symptoms in a cow's milk allergy mouse model and enhance regulatory T and B cell frequencies

Partially hydrolyzed whey proteins prevent clinical symptoms in a cow's milk allergy mouse model and enhance regulatory T and B cell frequencies

Induction of Oral Tolerance in Mice by Continuous Feeding with β-Lactoglobulin and Milk

Peptide‐Based Immunotherapy for Food Allergy

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