Induction of systemic and mucosal immune response in cattle by intranasal administration of pig serum albumin in alginate microparticles

Rebelatto, M. C.; Guimond, P. M.; Bowersock, T. L.; HogenEsch, Harm

doi:10.1016/s0165-2427(01)00370-1

Cited by 51 publications

(39 citation statements)

References 31 publications

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“…Sodium alginate has been used for preparing nanoparticles [29], microspheres [30][31][32][33][34][35], microcapsules [36], and beads [37] for oral delivery. In particularly, the use of alginate microparticles as an antigen delivery system has been described in several publications and there are some indications that they are able to induce a mucosal and systemic immune response in a variety of animal species by both oral and intranasal administration [38,39]. Over the last years, sodium alginate has also been used as a coating material for cells with some advantages.…”

Section: Various Routes For Vaccine Deliverymentioning

confidence: 99%

Novel antigen delivery technologies: a review

Jain

Singh

2011

Drug Deliv. and Transl. Res.

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Over the past few years, new insights into immunobiology and delivery systems have allowed the development of better vaccines and for a wider range of diseases. Currently available vaccines represent outstanding success story in modern medicine and have had a dramatic effect on morbidity and mortality worldwide. Conventional vaccines have been based on live attenuated, or killed, viruses or bacteria, or recombinant proteins from these organisms. The design of live attenuated vaccines depended to some extent on serendipity and resulted in low success rates. Both live attenuated and killed vaccines require handling of live pathogens and are associated with safety problems. Despite the success of vaccines, there is a clear need for novel antigen delivery technologies to improve vaccine efficacy and safety. Antigen stability, safety, and immunogenicity are the key hurdles in development of novel antigen delivery technologies. Nowadays, various novel drug delivery systems are becoming one of the fastest growing sectors in the pharmaceutical and biotechnological industries. Delivery of vaccines via oral, intranasal, transcutaneous, and intradermal routes will decrease the risk of needle-borne diseases and may eliminate the need for trained personnel and sterile equipment. Currently, various techniques involving DNA vaccines, adjuvants, nanoparticles, liposome, microneedle, and NanoMAP technology are being developed and evaluated. This review focuses on the current development of some novel vaccine delivery systems and will explore the non-parenteral routes of vaccine administrations.

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Section: Various Routes For Vaccine Deliverymentioning

confidence: 99%

Novel antigen delivery technologies: a review

Jain

Singh

2011

Drug Deliv. and Transl. Res.

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“…Oral immunization of cattle with the model antigen OVA in alginate microparticles enhanced IgA-and IgG-immune responses in the respiratory tract, providing evidence that oral immunization with microparticles can stimulate the common mucosal immune system in a large animal [17]. Calves immunized IN with porcine serum albumin (PSA) in alginate microparticles developed high level of anti-PSA IgG1 antibodies in serum, nasal secretions and saliva [128]. In contrast, oral immunization did not induce any significant responses, suggesting that IN was more efficient for induction of nasal and serum responses.…”

Section: Alginatementioning

confidence: 99%

Mucosal delivery of vaccines in domestic animals

et al. 2006

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-Mucosal vaccination is proving to be one of the greatest challenges in modern vaccine development. Although highly beneficial for achieving protective immunity, the induction of mucosal immunity, especially in the gastro-intestinal tract, still remains a difficult task. As a result, only very few mucosal vaccines are commercially available for domestic animals. Here, we critically review various strategies for mucosal delivery of vaccines in domestic animals. This includes live bacterial and viral vectors, particulate delivery-systems such as polymers, alginate, polyphosphazenes, immune stimulating complex and liposomes, and receptor mediated-targeting strategies to the mucosal tissues. The most commonly used routes of immunization, strategies for delivering the antigen to the mucosal surfaces, and future prospects in the development of mucosal vaccines are discussed. mucosal / vaccine / livestock / animals / review

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“…It is cross-linked with calcium ions to form gel, known as "the egg-box model" (11,12). Generally, it can be used as living cell encapsulant matrices (13), wound dressings (14), and intranasal drug delivery devices (15). In addition, it can encapsulate angiogenic growth factors, such as basic fibroblast growth factor (bFGF) and the vascular endothelial growth factor (VEGF) to treat ischemia.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Silver Nanoparticles-Loaded Calcium Alginate Beads Embedded in Gelatin Scaffolds

et al. 2014

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Abstract. Silver nanoparticles (AgNPs)-loaded alginate beads embedded in gelatin scaffolds were successfully prepared. The AgNPs-loaded calcium alginate beads were prepared by electrospraying method. The effect of alginate concentration and applied voltage on shape and diameter of beads was studied. The diameter of dry AgNPs-loaded calcium alignate beads at various concentrations of AgNO 3 ranged between 154 and 171 μm. The AgNPs-loaded calcium alginate beads embedded in gelatin scaffolds were fabricated by freeze-drying method. The water swelling and weight loss behaviors of the AgNPs-loaded alginate beads embedded in gelatin scaffolds increased with an increase in the submersion time. Moreover, the genipin-cross-linked gelatin scaffolds were proven to be nontoxic to normal human dermal fibroblasts, suggesting their potential uses as wound dressings.

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Induction of systemic and mucosal immune response in cattle by intranasal administration of pig serum albumin in alginate microparticles

Cited by 51 publications

References 31 publications

Novel antigen delivery technologies: a review

Novel antigen delivery technologies: a review

Mucosal delivery of vaccines in domestic animals

Preparation and Characterization of Silver Nanoparticles-Loaded Calcium Alginate Beads Embedded in Gelatin Scaffolds

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