Induction of superovulation by inhibin vaccine in cyclic guinea-pigs

Shi, Fangxiong; Ozawa, Manao; Komura, Hisashi; Watanabe, Genichi; Tsonis, CG; Suzuki, AK; Taya, Kazuyoshi

doi:10.1530/jrf.0.1180001

Cited by 18 publications

(5 citation statements)

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“…Taya and Watanabe established such a system using anti-inhibin serum (AIS). According to their protocol, endogenous inhibin secretion can be neutralized by injecting AIS, and as a result, endogenous follicle-stimulating hormone (FSH) secretion from the pituitary gland is maintained at high levels, thus inducing much larger numbers of developing follicles in a variety of species including laboratory and domestic animals [ 51 , 52 , 53 , 54 , 55 , 56 ]. Using AIS–hCG injections we succeeded in collecting approximately 25 oocytes per female mouse in MSM and JF1 mice [ 57 ] and in wild-derived strains of Mus musculus molossinus [ 58 ].…”

Section: Superovulationmentioning

confidence: 99%

Development of assisted reproductive technologies in small animal species for their efficient preservation and production

Mochida

2020

Journal of Reproduction and Development

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Assisted reproductive technologies (ARTs) are widely used in the animal industry, human clinics, and for basic research. In small laboratory animal species such as mice, ARTs are essential for the production of animals for experiments, the preservation of genetic resources, and for the generation of new strains of genetically modified animals. The RIKEN BioResource Research Center (BRC) is one of the largest repositories of such animal bioresources, and maintains approximately 9,500 strains of mice with a variety of genetic backgrounds. We have sought to devise ARTs specific to the reproductive and physiological characteristics of each strain. Such ARTs include superovulation, in vitro fertilization (IVF), the cryopreservation of embryos and spermatozoa, transportation of cryopreserved materials and embryo transfer (ET). Of these, superovulation likely has the most influence on animal production because it determines the quantity of starting material for other ARTs. Superovulation using anti-inhibin serum combined with estrous synchronization has resulted in approximately a threefold increase in production efficiency with IVF-ET in the C57BL/6J strain. Wild-derived strains are important as genetically diverse resources for murine rodents (Genus Mus), and many are unique to the BRC. We have also successfully developed ARTs for more than 50 wild-derived strains, which have been cryopreserved for future use. Our work to improve and develop ARTs for mice and other small laboratory species will contribute to the cost-effectiveness of routine operations at repository centers, and to the provision of high quality animals for research use.

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Section: Superovulationmentioning

confidence: 99%

Development of assisted reproductive technologies in small animal species for their efficient preservation and production

Mochida

2020

Journal of Reproduction and Development

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“…Neutralization of its biological activity by active and passive immunization (Ishigame et al, 2004) against inhibin led to increases in pituitary secretion and the plasma concentration of FSH, which was thought to stimulate development of, or select for, increased follicles in the final maturation stage (Shi et al, 2000;Ozawa et al, 2001;Medan et al, 2004;Ishigame et al, 2004). In addition, because of its inhibitory action on FSH secretion, inhibin has been widely used in the treatment of superovulation.…”

Section: Introductionmentioning

confidence: 99%

Polymorphism of the inhibin βA gene and its relationship with superovulation traits in Chinese Holstein cows

Chen

Yang

2014

Genet. Mol. Res.

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ABSTRACT. Inhibin is a major regulator of secretion of folliclestimulating hormone, which is involved in follicular development and regulation of steroidogenesis in females. The objectives of this study were to detect polymorphisms of the bovine inhibin beta-A subunit (INHβA) gene and to evaluate its associations with superovulatory responses in 171 Chinese Holstein cows treated for superovulation. Polymerase chain reaction-restricted fragment length polymorphism revealed a C>T transition determining the StyI polymorphism at position 7639 in intron I of the bovine INHβA gene, and three genotypes (CC, CT, and TT) were detected. The frequencies of the three genotypes showed a tendency for CT > TT > CC, and this polymorphism was in Hardy-Weinberg equilibrium. Statistical analysis revealed no significant differences of least square means for superovulation traits among the three genotypes (P > 0.05). These results demonstrate, for the first time,

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“…1998), goats (Medan et al . 2003a) and guinea pigs (Shi et al . 2000a,b), active immunization against inhibin increased ovarian activity and ovulation rate through an increase in FSH secretion.…”

Section: Introductionmentioning

confidence: 99%

Inhibin: Regulation of reproductive function and practical use in females

Medan

Arai

Watanabe

et al. 2007

Animal Science Journal

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Inhibins are gonadal glycoprotein hormones selectively and potently inhibiting follicle‐stimulating hormone (FSH) secretion from the pituitary gland. Inhibins are produced mainly by the ovary and are purified from follicular fluid. Inhibins were shown to be produced in two forms through dimeric assembly of an α‐subunit and one of two closely related β‐subunits to form inhibin A (α‐βA) and inhibin B (α‐βB). Although inhibin subunits are expressed in various tissues, the gonads are the major source of circulating inhibins. While inhibins may act as a paracrine or autocrine factor in some tissues, their best understood roles are as endocrine regulators of pituitary FSH. In this review we focus our attention on more recent developments in inhibin research. We describe patterns of inhibin A and B secretion during the estrous cycle. We also review the immunization against inhibin α subunit as a practical method for superovulation. Superovulation has been induced successfully by passive or active immunization against the inhibin α‐subunit in several species such as mice, rats, hamsters, guinea pigs, cows, mares, ewes and goats. Furthermore, several studies have shown that oocytes superovulated with immunization against inhibin α‐subunit have the ability to develop normally, suggesting that inhibin immunization could be used as a practical method for superovulation in a wide range of animal species.

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Induction of superovulation by inhibin vaccine in cyclic guinea-pigs

Cited by 18 publications

References 1 publication

Development of assisted reproductive technologies in small animal species for their efficient preservation and production

Development of assisted reproductive technologies in small animal species for their efficient preservation and production

Polymorphism of the inhibin βA gene and its relationship with superovulation traits in Chinese Holstein cows

Inhibin: Regulation of reproductive function and practical use in females

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