Induction of stress proteins and MMP-9 by 0.8ppm of ozone in murine skin

Valacchi, Giuseppe; Pagnin, Elisa; Okamoto, Tatsuya; Corbacho, Ana; Olano, Estibaliz; Davis, Paul A.; Vliet, Albert van der; Packer, Lester; Cross, Carroll E.

doi:10.1016/s0006-291x(03)00812-x

Cited by 68 publications

(62 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These results are in line with previous published studies that examined the effect of air pollution on skin diseases and, more specifically, on cellulitis [19][20][21][22][23]. As cellulitis is caused by various bacteria, it has been proposed to identify the bacteria levels in diagnosis of patients.…”

Section: Cellulitissupporting

confidence: 89%

“…Significant positive results were also observed for NO 2 and SO 2 among both males and females. These results agree with previous published studies in which have been examined the effect of air pollution on skin diseases [19][20][21]. In a study in Bordeaux, France, from 2000 to 2006 [19], Larrier et al explored links between daily levels of air pollutions and medical home visits made for several reasons.…”

Section: Skin Conditions Other Than Cellulitissupporting

confidence: 88%

“…Many studies have shown that O 3 affects respiratory health [2][3][4][5][6][7][8][9][10][11], is a risk factor for respiratory conditions such as asthma [12,13] and may even be linked to nonrespiratory conditions [13][14][15][16]. Moreover exposure to ambient O 3 has been associated with skin stress-responses and also various skin conditions [17][18][19][20] including cellulitis [21,22]. Human skin acts as a protective and active biological shield against pro-oxidative chemical products and air pollutants [23].…”

mentioning

confidence: 99%

See 2 more Smart Citations

Ambient air pollution and emergency department visits for skin conditions

Szyszkowicz¹,

Kousha²,

Valacchi³

2016

Glob Dermatol

Self Cite

View full text Add to dashboard Cite

that ambient air pollution exposure may affect skin barrier function and allow exogenous bacteria to penetrate in the cutaneous tissues. In addition, recent studies have documented a strong correlation between cellulitis and ozone exposure for the parts of cutaneous tissues that are less covered by clothes [21]. The hypothesis that stronger associations for cellulitis are observed in area that are in direct contact with air pollutants was proposed and verified by the first author of this work [21].In this study, a case-crossover (CC) technique was used to evaluate any potential association between emergency department ED visits for cellulitis and other skin conditions with ambient air pollution [25]. The CC method allows to adjust the results for time trend and the seasonal variability. ED visits for a wide range of skin conditions, including urticaria (hives), cellulitis, dermatitis and rashes, were used to represent health outcomes. The CC method was realized on clusters defined by individual cases-control strata to avoid potential bias [26].This work assesses potential impacts of ambient air pollution to human skin condition development. From our data we can propose that increase in ambient air pollution levels can exacerbate various health conditions, among them the ones related to skin as well. In addition, it is possible that skin chronic exposure to air pollution can IntroductionThe human skin is the body's first and main barrier of defense against environmental stressors such as air pollution and ultraviolet irradiation (UV) [1]. The upper layer of the epidermis is mainly one of the first and major targets of air pollutants. Ground-level ozone (O 3 ) is one of the most reactive environmental oxidants and the main component of photochemical smog. Many studies have shown that O 3 affects respiratory health [2][3][4][5][6][7][8][9][10][11], is a risk factor for respiratory conditions such as asthma [12,13] and may even be linked to nonrespiratory conditions [13][14][15][16]. Moreover exposure to ambient O 3 has been associated with skin stress-responses and also various skin conditions [17][18][19][20] including cellulitis [21,22]. Human skin acts as a protective and active biological shield against pro-oxidative chemical products and air pollutants [23]. Exposure of the skin to ambient air pollution may have negative impact on the skin health condition and affect skin homeostasis.In this study short-term exposure to ambient air pollution is considered. The aim of this study was to investigate potential correlation between ambient air pollution exposures, especially ozone, and emergency department (ED) visits for skin conditions during the period from April 2004 to December 2011 in nine cities across the province of Ontario, Canada: Algoma (district), Halton (municipality), Hamilton, London, Ottawa, Peel (municipality), Toronto, Windsor and York. It has been shown that results from multi-city studies are more reliable and are less susceptible to biases than those from single locations [24].In this study ED...

show abstract

Section: Cellulitissupporting

confidence: 89%

Section: Skin Conditions Other Than Cellulitissupporting

confidence: 88%

mentioning

confidence: 99%

See 1 more Smart Citation

Ambient air pollution and emergency department visits for skin conditions

Szyszkowicz¹,

Kousha²,

Valacchi³

2016

Glob Dermatol

Self Cite

View full text Add to dashboard Cite

show abstract

“…These changes can be attributed to the proliferation of the keratinocytes and the enhanced mitotic turnover rates of the epithelial cells. The connective tissue stroma displayed reduced bundles of the collagen fibers, which were earlier highly collagenized with numerous plump fibroblasts [20][21][22].…”

Section: Discussionmentioning

confidence: 99%

The Morphometrical and Histopathological Changes which were Observed after Topical Ozone Therapy on an Exophytic Fibrous Gingival Lesion: A Case Report

Patel

Gujjari²

2013

JCDR

View full text Add to dashboard Cite

We are presenting 2 cases where ozone therapy was used in the form of ozonated oil on an exophytic fibrous gingival lesion. A 42-years female patient was selected, who presented with a mild to moderately painful, exophytic, fibrous lesion on the upper anterior gingiva. This gingival lesion was treated with 2ml of ozonated oil, thrice daily for one week. After the ozone therapy, the postoperative outcomes were measured and analyzed. Finally, the lesion was subjected to an excisional biopsy and a histopathological evaluation. After the ozone therapy, the patient revealed that there was less pain. On examination of the lesion, an improvement was observed in the clinical sign of the inflammation and also a reduction in the surface ulceration. During the final biopsy, less bleeding was observed. The morphometrical analysis showed a reduction in the size of the lesion. The histopathological analysis showed a reduction in the collagen fibres and in the inflammatory cells in the connective tissue stroma. Topical ozone therapy provides potential benefits for the treatment of exophytic gingival lesions. The observed benefits in present case report needs to be verified in future with well-controlled clinical trials.

show abstract

“…Ozone exposure can influence antioxidant levels and oxidation markers in the outermost stratum corneum layer [67,68]. The changes in the oxidant levels and oxidation markers induce cellular stress responses in the deeper skin cells [69]. The chronic exposure of the skin to environmental stressors can overwhelm the skin's defensive system comprised of both enzymatic and non-enzymatic low molecular weight antioxidants [70], and induces persistent damage to cutaneous tissues.…”

Section: Pollution and Its Effect On The Skinmentioning

confidence: 99%

Potential Use of Spin Traps to Control ROS in Antipollution Cosmetics—A Review

Sawant¹

2018

Cosmetics

View full text Add to dashboard Cite

Abstract:Pollution from air and sunlight has adverse effects on human health, particularly skin health. It creates oxidative stress, which results in skin diseases, including skin cancer and aging. Different types of antioxidants are used as preventative actives in skin-care products. However, they have some limitations as they also scavenge oxygen. Recently, spin traps are being explored to trap free radicals before these radicals generating more free radicals (cascading effect) and not the oxygen molecules. However, not all spin traps can be used in the topical cosmetic skin-care products due to their toxicity and regulatory issues. The present review focuses on the different pathways of reactive oxygen species (ROS) generation due to pollution and the potential use of spin traps in anti-pollution cosmetics to control ROS.

show abstract

Induction of stress proteins and MMP-9 by 0.8ppm of ozone in murine skin

Cited by 68 publications

References 39 publications

Ambient air pollution and emergency department visits for skin conditions

Ambient air pollution and emergency department visits for skin conditions

The Morphometrical and Histopathological Changes which were Observed after Topical Ozone Therapy on an Exophytic Fibrous Gingival Lesion: A Case Report

Potential Use of Spin Traps to Control ROS in Antipollution Cosmetics—A Review

Contact Info

Product

Resources

About