Induction of spinal seizures by natural stimulation in cats

Yü, Jen; Chambers, W. W.; Liu, C.N.; Herdman, Susan J.; Chen, W.P.

doi:10.1016/0006-8993(84)90713-3

Cited by 6 publications

(3 citation statements)

References 16 publications

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“…It is therefore possible, as has been done by others (Davenport et al, 1977), to use spinal paroxysms as a less complicated model for paroxysmal events characteristic of epileptic foci in supraspinal central nervous system structures. Spinal cord seizures have been reported both in humans and animals (Kao and Crill, 1972;Bordbar and Behishti, 1975;Lothman and Somjen, 1976;Ryan et al, 1984;Yu et al, 1984;Cherrick and Ellenberg, 1986;Schlag et al, 2000). In animals this seizure activity has many of the features similar to seizures induced in the cerebral cortex (Cherrick and Ellenberg, 1986).…”

Section: Discussionmentioning

confidence: 91%

Right‐sided vagus nerve stimulation inhibits induced spinal cord seizures

Tubbs¹,

Salter²,

Killingsworth³

et al. 2005

Clinical Anatomy

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We have previously shown that left-sided vagus nerve stimulation results in cessation of induced spinal cord seizures. To test our hypothesis that rightsided vagus nerve stimulation will also abort seizure activity, we have initiated seizures in the spinal cord and then performed right-sided vagus nerve stimulation in an animal model. Four pigs were anesthetized and placed in the lateral position and a small laminectomy performed in the lumbar region. Topical penicillin, a known epileptogenic drug to the cerebral cortex and spinal cord, was next applied to the dorsal surface of the exposed cord. With the exception of the control animal, once seizure activity was discernible via motor convulsion or increased electrical activity, the right vagus nerve previously isolated in the neck was stimulated. Following multiple stimulations of the vagus nerve and with seizure activity confirmed, the cord was transected in the midthoracic region and vagus nerve stimulation performed. Right-sided vagus nerve stimulation resulted in cessation of spinal cord seizure activity in all animals. Transection of the spinal cord superior to the site of seizure induction resulted in the ineffectiveness of vagus nerve stimulation in causing cessation of seizure activity in all study animals. As with left-sided vagus nerve stimulation, right-sided vagus nerve stimulation results in cessation of induced spinal cord seizures. Additionally, the effects of right-sided vagus nerve stimulation on induced spinal cord seizures involve descending spinal pathways. These data may aid in the development of alternative mechanisms for electrical stimulation for patients with medically intractable seizures and add to our knowledge regarding the mechanism for seizure cessation following peripheral nerve stimulation. Clin. Anat. 20:23-26, 2007. V V C 2005 Wiley-Liss, Inc.

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Section: Discussionmentioning

confidence: 91%

Right‐sided vagus nerve stimulation inhibits induced spinal cord seizures

Tubbs¹,

Salter²,

Killingsworth³

et al. 2005

Clinical Anatomy

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“…The issue of spinal-induced seizure is well documented in the literature and commonly used for experimental purposes. [67] The investigations on vagus nerve stimulation on induced spinal cord seizure confirm the seizure with a merely spinal origin. [8] Neurons of the spinal cord, just as in the cerebral cortex, are known to become hyperactive and cause spinal cord “seizures.”[9] Transection of the spinal cord of the cat at a thoracic or lumbar level results in an altered excitability that repeated natural stimulation of the dermatome just caudal to the transection site will induce seizure discharges.…”

Section: Discussionmentioning

confidence: 92%

“…[8] Neurons of the spinal cord, just as in the cerebral cortex, are known to become hyperactive and cause spinal cord “seizures.”[9] Transection of the spinal cord of the cat at a thoracic or lumbar level results in an altered excitability that repeated natural stimulation of the dermatome just caudal to the transection site will induce seizure discharges. [7] Spinal seizure has been reported in humans with transverse myelopathy as well. [10] Although our patients had no paresis before surgery and no cord injury happened during the procedure, it is possible that minor surgical manipulation had stimulated the neural pathways to act as a trigger zone for spinal seizure.…”

Section: Discussionmentioning

confidence: 99%

Possible causes of seizure after spine surgery

2010

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Seizure after laminectomy for spinal procedure is very rare and has not been reported after lipomyelomeningocele surgery beforehand. Here, two cases of seizure following laminectomy for lipomyelomeningocele are reported. The exact etiology of the event is unknown but anesthetic material, pneumocephalus, intracranial hypotension subsequent to cerebrospinal fluid leakage after spinal procedures, spinal-induced seizure and the potential toxic effect of fat molecules could be considered.

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Cisplatin‐induced Neurotoxicity with Seizures in Frogs

Blisard

Harrington

1989

Annals of Neurology

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Cis-diamminedichloroplatinum II (cisplatin) given by injection to adult frogs (Rana pipiens) resulted in tonic-clonic seizures 3 to 5 weeks later. The seizures could be induced multiple times; the animals appeared entirely normal between seizures. In the spinal cord there was vacuolation in the anterior grey horns. Ultrastructurally, the vacuoles consisted of swollen astrocytic processes in the neuropil and around neurons. Generalized edema with swelling of perivascular astrocyte foot processes was not seen. Systemic administration of cisplatin to frogs results in neurotoxicity with seizures and astrocytic swelling in the spinal cord.

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Induction of spinal seizures by natural stimulation in cats

Cited by 6 publications

References 16 publications

Right‐sided vagus nerve stimulation inhibits induced spinal cord seizures

Right‐sided vagus nerve stimulation inhibits induced spinal cord seizures

Possible causes of seizure after spine surgery

Cisplatin‐induced Neurotoxicity with Seizures in Frogs

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