Induction of spermidine N1-acetyltransferase by 1 alpha,25-dihydroxyvitamin D3 as an early common event in the target tissues of vitamin D.

Shinki, Toshimasa; Takahashi, Naoyuki; Kadofuku, Tsuyoki; Sato, Tsuneo; Suda, Toshio

doi:10.1016/s0021-9258(18)89535-7

“…The relationship between some of these differentially affected metabolites like spermidine have been previously reported. The previous studies have indicated that spermidine N1-acetyltransferase activity by 1 alpha,25(OH) 2 D 3 is earliest induced metabolite reported to date and that the 1 alpha,25(OH) 2 D 3 -induced duodenal synthesis of putrescine occurs by the pathways from both ornithine and spermidine (10). Furthermore, some studies have suggested that both spermidine and spermine are involved in the activation of vitamin D receptor (9, 10).…”

Section: Discussionmentioning

confidence: 99%

“…The experimental studies have shown that polyamines activate the vitamin D receptor in vitro and it is possible that they are related to the regulation of vitamin D action (9). The enhancement of spermidine N-acetyltransferase activity by 1,25-dihydroxyvitamin D is observed not only in the classical target tissues but also in the newly recognized target tissues of vitamin D (10). Some of these target tissues do not appear to be involved in the regulation of mineral metabolism.…”

mentioning

confidence: 99%

Variable Genomic and Metabolomic Responses to Varying Doses of Vitamin D Supplementation

Shirvani

¹

,

Kalajian

²

,

Song

³

et al. 2019

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Background/Aim: To assess the impact of vitamin D supplementation on genomic and metabolomic profiles and relate them to the individual's responsiveness to varying doses of vitamin D 3 . Patients and Methods: Healthy adults were given either 600, 4000 or 10,000 IUs vitamin D 3 /day for 6 months. Circulating parathyroid hormone (PTH), 25hydroxyvitamin D [25(OH)D], calcium, peripheral white blood cells broad gene expression and urine and serum metabolomic profiles were evaluated. Results: There was a dose-dependent effect of vitamin D supplementation on serum 25(OH)D, PTH and broad gene expression. Serum calcium levels remained normal for all study subjects and no untoward toxicity was observed. The metabolomic profiles were related to the genomic expression analysis. There were significant inter-individual effects on gene expression and metabolomic profile in response to the same dose of vitamin D 3 supplementation, despite similar changes in 25(OH)D and PTH concentrations. Conclusion: These results may help explain the variability observed in clinical trials regarding vitamin D's non-calcemic health benefits.

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“…How vitamin D modulates cell proliferation is still unclear; however, evidence suggests that it may be through effects on polyamine metabolism ( 26 , 27 ). Polyamines (putrescine, spermidine, and spermine) have a significant role in cell proliferation and differentiation ( 28 ).…”

Section: Resultsmentioning

confidence: 99%

“…Polyamines (putrescine, spermidine, and spermine) have a significant role in cell proliferation and differentiation ( 28 ). An injection of 1,25OHD3, the most active vitamin D metabolite increased the conversion of ornithine and spermidine into putrescine in the duodenum of the D-deficient chicks ( 27 ). Furthermore, 1,25OHD3 enhances the activity of ornithine decarboxylase and spermidine N-acetyltransferase rate, limiting enzymes in the conversion of ornithine and spermidine into putrescine ( 27 ).…”

Section: Resultsmentioning

confidence: 99%

“…An injection of 1,25OHD3, the most active vitamin D metabolite increased the conversion of ornithine and spermidine into putrescine in the duodenum of the D-deficient chicks ( 27 ). Furthermore, 1,25OHD3 enhances the activity of ornithine decarboxylase and spermidine N-acetyltransferase rate, limiting enzymes in the conversion of ornithine and spermidine into putrescine ( 27 ). Therefore, the modulation of duodenal epithelial cell proliferation by vitamin D, may be due to its effects on putrescine synthesis efficiency; nevertheless, further studies are required to fully elucidate this mechanism.…”

Section: Resultsmentioning

confidence: 99%

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Combined Maternal and Post-Hatch Dietary Supplementation of 25-Hydroxycholecalciferol Alters Early Post-Hatch Broiler Chicken Duodenal Macrophage and Crypt Cell Populations and Their Mitotic Activity

Leiva

¹

,

Avila

²

,

Abascal-Ponciano

³

et al. 2022

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The previous work has demonstrated that maternal supplementation of the circulating metabolite of vitamin D3 (D3), 25-hydroxycholecalciferol (25OHD3), enhances the immunocompetence of broiler chick offspring. In post-hatch broiler diets, 25OHD3 has been shown to affect intestinal morphology and improve the immune status of broilers. An experiment with a 2 × 2 factorial treatment arrangement was conducted to assess the effects of combining maternal (MDIET) and post-hatch (PDIET) dietary 25OHD3 inclusion on duodenal crypt and macrophage cell populations and mitotic activity in young broiler chickens. All diets were formulated to provide 5,000 IU of vitamin D. Broiler breeder hens were offered 1 of 2 MDIET: 5,000 IU D3 per kg of feed (MCTL) or 2,240 IU of D3 + 2,760 IU of 25OHD3 per kg of feed (M25OHD3) from week 25 to 41. Male broiler offspring (n = 480) hatched from eggs collected during week 41 of breeding age were allotted in raised floor pens (4 birds per pen from day 0 to 7 and individually allotted from day 8 to 21). Chicks were fed 1 of 2 PDIET (starter day 0 to 21): 5,000 IU D3 per kg of feed (PCTL) or 2,240 IU D3 + 2,760 IU 25OHD3 (P25OHD3). DUO samples (n = 12 birds per treatment per day) were collected on days 3, 6, 9, 12, 15, 18, and 21 for cryohistological and immunofluorescence analysis to facilitate the enumeration of the total macrophages, CD80+ macrophages (pro-inflammatory macrophages), and mitotically active cells (BrdU+) to calculate the proportion of proliferating cells (PPC) per duodenal crypt. Bird age impacted crypt PPC with the greatest PPC per duodenal crypt observed on days 3 and 9, and the lowest PPC per crypt was observed on day 21 (P < 0.0001). Broilers from the M25OHD3:PCTL treatment had a greater PPC (P =.002) than birds from the MCTL:PCTL treatment at day 3. An interaction among MDIET and PDIET was observed for proliferating macrophages at day 21 (P = 0.029) where M25OHD3:P25OHD3 birds had more proliferating macrophages than M25OHD3:PCTL-fed birds. These results indicate that combined MDIET and PDIET 25OHD3 supplementation may alter early post-hatch duodenal development and innate immunity.

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Vitamin D Endocrine System and Calcium and Phosphorus Homeostasis

Gross

¹

,

Kumar

²

1992

Comprehensive Physiology

0

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The sections in this article are: Physiological Effects of Vitamin D and its Active Metabolites on Calcium and Phosphorus Homeostasis Sources of Vitamin D Transport of Vitamin D and its Metabolites in Plasma Metabolism of Vitamin D 3 to 25‐Hydroxyvitamin D 3 Metabolism of 25‐Hydroxyvitamin D 3 Regulation of the 25‐Hydroxyvitamin D 3 –1α‐Hydroxylase Enzyme Parathyroid Hormone Phosphorus Concentrations Calcium: Direct Effects 1,25‐Dihydroxyvitamin D 3 Calcitonin Hydrogen Ion Sex Steroids Glucocorticoids Pituitary Hormones Thyroid Hormone Pregnancy Catabolism of 1,25‐Dihydroxyvitamin D 3 Physiological Adaptations that Occur in Response to Changes in Serum Calcium and Phosphate Concentrations Hypocalcemia and Hypercalcemia Hypophosphatemia and Hyperphosphatemia Pathophysiology and Physiology of the 1,25‐Dihydroxyvitamin D 3 System Mechanisms of Action of 1,25‐Dihydroxyvitamin D 3 1,25‐Dihydroxyvitamin D 3 in the Intestine Processes in the Cell That Are Mediated by 1,25‐Dihydroxyvitamin D 3 Intestinal Brush Border Events Induced by 1,25‐Dihydroxyvitamin D 3 Events at the Contraluminal Border Effects of 1,25‐Dihydroxyvitamin D 3 on the Intestinal Cell 1,25‐Dihydroxyvitamin D 3 in the Kidney

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Induction of spermidine N1-acetyltransferase by 1 alpha,25-dihydroxyvitamin D3 as an early common event in the target tissues of vitamin D.

Cited by 48 publications

References 44 publications

Variable Genomic and Metabolomic Responses to Varying Doses of Vitamin D Supplementation

Variable Genomic and Metabolomic Responses to Varying Doses of Vitamin D Supplementation

Combined Maternal and Post-Hatch Dietary Supplementation of 25-Hydroxycholecalciferol Alters Early Post-Hatch Broiler Chicken Duodenal Macrophage and Crypt Cell Populations and Their Mitotic Activity

Vitamin D Endocrine System and Calcium and Phosphorus Homeostasis

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