2002
DOI: 10.1016/s0264-410x(02)00029-4
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Induction of specific Th1 responses and suppression of IgE antibody formation by vaccination with plasmid DNA encoding Der f 11

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Cited by 45 publications
(56 citation statements)
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“…Similar results have been demonstrated with DNA vaccines encoding allergens of house dust mite [12,19,20,21,22,23] and a DNA vaccine coding for the major milk allergen bovine β-lactoglobulin [24]. …”
Section: Th1-biased Immunity – the Key To Dna-based Allergy Vaccinationsupporting
confidence: 76%
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“…Similar results have been demonstrated with DNA vaccines encoding allergens of house dust mite [12,19,20,21,22,23] and a DNA vaccine coding for the major milk allergen bovine β-lactoglobulin [24]. …”
Section: Th1-biased Immunity – the Key To Dna-based Allergy Vaccinationsupporting
confidence: 76%
“…Both CD4+ and CD8+ T cells from DNA-immunized animals have been shown to contribute to the suppression of IgE antibody production by affecting the primary response and/or by propagating the Th1 memory response in a passive cell transfer system [11, 12]. …”
Section: Th1-biased Immunity – the Key To Dna-based Allergy Vaccinationmentioning
confidence: 99%
“…Moreover, the role of T cells underlying the suppression of IgE by DNA vaccination remains controversial. Whereas Hsu et al [17] found that only CD8+ T cells were the immunoregulatory T cells in DNA vaccination, the other reports found that both CD4+ and CD8+ T cells played some roles in DNA vaccination [20]. In the present study, we have also sought evidence that both CD4+ and CD8+ T cells play crucial roles in pCyn d 1-vaccinated mice.…”
Section: Introductionmentioning
confidence: 56%
“…Recent studies have shown that DNA vaccination is a simple approach to activate Th1 responses [17,18,19,20,21,22,23,24]. Unlike protein vaccines, DNA vaccines induce long-lasting intracellular expression of recombinant allergens and generate specific Th1 cells secreting predominantly interferon-γ (IFN-γ) [18,19,20,21,22,23]. IFN-γ can selectively inhibit activation of Th2 cells and IgE production by B cells [25].…”
Section: Introductionmentioning
confidence: 99%
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