Induction of salivary antibodies to inhibitCandida albicansadherence to human epithelial cells by tonsillar immunization in rabbits

Abstract

To examine the possibility of a vaccine for Candida albicans infection in the oral cavity, we induced salivary antibodies by immunization of killed-C. albicans ATCC 18804 on the palatine tonsils of rabbits. The enzyme-linked immunosorbent assay reaction of salivary antibodies was high against C. albicans serotype A. The saliva antibodies greatly inhibited C. albicans adherence to cloned epithelial cells from human gingiva. Tonsillar immunizations of C. albicans ATCC 18804 induce salivary antibodies that prevent C. albicans adherence to epithelial cells, and thus should prove useful in the prevention of oral candidiasis caused by C. albicans serotype A.

Antimicrobial effect of edible mixed herbal extracts on oral microorganisms

“…In other studies, dental plaque formation was inhibited, and gingivitis was prevented by mouthrinse containing eucalyptol and thymol as the main components or mouthrinse containing cetylpyridinium chloride, both of which exhibit outstanding antimicrobial effects on oral pathogens [23,24]. However, antibiotics as the main components of mouthrinse can have harmful physiological effects and induce adverse side effects, from antibiotic-resistance to superinfection [25]. Long-term use of mouthrinse can also discolor the teeth or soft tissue and alter the sense of taste [26].…”

Antibody response to the 45 kDa Candida albicans antigen in an animal model and potential role of the antigen in adherence

“…Candida albicans is the most frequently isolated fungal pathogen associated with infection of immunocompromised patients in hospital settings. The high propensity to cause disease is due to the expression of many virulence factors including highly immunogenic cell surface proteins (Alberti-Segui et al, 2004;Jeng et al, 2005;Pietrella et al, 2006) able to trigger cellular and humoral response (Viudes et al, 2001;Ló pez-Ribot et al, 2004;Omaetxebarria et al, 2005;Fukuizumi et al, 2006). Additionally, a variety of cell surface molecules expressed by Candida help it to evade the host immune response by mimicry of host receptors (Gustafson et al, 1991;Phan et al, 2007).…”