Induction of reproductive cell death in Caenorhabditis elegans across entire linear-energy-transfer range of carbon-ion irradiation

Chen, Liangwen; Tang, Honggang; Du, Yuguo; Dai, Zhangyu; Wang, Ting; Wu, Lijun; Zhou, Libin; Bian, Po

doi:10.1016/j.dnarep.2018.01.009

Cited by 6 publications

(4 citation statements)

References 36 publications

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“…With an adaptive gammaradiation, it took C. Elegans vulva cells 1.75 h to develop radio resistance, and this resistance may Persis for only 2-4 h. DNA damage checkpoints and non-homologous end-joining (NHEJ) were involved in radio adaptive response in a cellular non-autonomous manner. NHEJ pathway, one of DNA damage repair pathway, plays an important role inradioadaptiveresponse, while HR pathway, another DNA damage repair pathway, were involved in carbon ion source radiation-induced DNA damage, but not in radio adaptive response [7,8]. ATM-1, but not HUS-1, were involved in germ lines radio adaptive response induced by microbeam [7].…”

Section: Mini Reviewmentioning

confidence: 97%

Caenorhabditis Elegans as a Model of Radio adaptive Response and Radiation-Induced Bystander Effect

Liu

Chen

Zhang

et al. 2018

BJSTR

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Section: Mini Reviewmentioning

confidence: 97%

Caenorhabditis Elegans as a Model of Radio adaptive Response and Radiation-Induced Bystander Effect

Liu

Chen

Zhang

et al. 2018

BJSTR

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“…Huangqui et al demonstrated the radio-adaptive response for reproductive cell death in the valval tissue in C. elegans for the first time and showed that the C. elegans is an excellent in vivo model for radiation-induced reproductive cell death [93]. Similarly, Liangwen et al demonstrated reproductive cell death across the entire range of carbon-ion irradiation [94] These studies opened new horizons on radiation-induced reproductive cell death in C. elegans and further confirmed that this nematode is an excellent model to study human reproductive cell death from the radiation therapy that is used in cancer therapy.…”

Section: And 24 Gymentioning

confidence: 99%

Review of Biological Effects of Acute and Chronic Radiation Exposure on Caenorhabditis elegans

Dhakal

Yosofvand

Yavari

et al. 2021

Cells

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Knowledge regarding complex radiation responses in biological systems can be enhanced using genetically amenable model organisms. In this manuscript, we reviewed the use of the nematode, Caenorhabditis elegans (C. elegans), as a model organism to investigate radiation’s biological effects. Diverse types of experiments were conducted on C. elegans, using acute and chronic exposure to different ionizing radiation types, and to assess various biological responses. These responses differed based on the type and dose of radiation and the chemical substances in which the worms were grown or maintained. A few studies compared responses to various radiation types and doses as well as other environmental exposures. Therefore, this paper focused on the effect of irradiation on C. elegans, based on the intensity of the radiation dose and the length of exposure and ways to decrease the effects of ionizing radiation. Moreover, we discussed several studies showing that dietary components such as vitamin A, polyunsaturated fatty acids, and polyphenol-rich food source may promote the resistance of C. elegans to ionizing radiation and increase their life span after irradiation.

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“…In addition, heavy ion beam irradiation (HIBI), a novel and more efficient irradiation method for strain mutagenesis, has unique physical and biological advantages due to its high linear energy transfer and relative biological effectiveness, wide mutation spectrum, and high mutation rate ( Gao et al, 2020 ; Guo et al, 2020 ; Zhang et al, 2022 ). Previous studies have demonstrated that HIBI produces a high mutation rate, mainly attributed to deletions, nucleotide exchange, and insertions ( Chen et al, 2018 ). However, the combined application of ARTP and HIBI mutagenesis to enhance MP production has not been reported.…”

Section: Introductionmentioning

confidence: 99%

Increased Water-Soluble Yellow Monascus Pigment Productivity via Dual Mutagenesis and Submerged Repeated-Batch Fermentation of Monascus purpureus

et al. 2022

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Monascus pigments (MPs) have been used in the food industry for more than 2,000 years and are known for their safety, bold coloring, and physiological activity. MPs are mainly yellow (YMPs), orange (OMPs), and red (RMPs). In this study, a mutant strain Monascus purpureus H14 with high production of water-soluble YMPs (WSYMPs, λmax at 370 nm) was generated instead of primary YMPs (λmax at 420 nm), OMPs (λmax at 470 nm), and RMPs (λmax at 510 nm) produced by the parent strain M. purpureus LQ-6 through dual mutagenesis of atmospheric and room-temperature plasma and heavy ion beam irradiation (HIBI), producing 22.68 U/ml extracellular YMPs and 10.67 U/ml intracellular YMPs. WSYMP production was increased by 289.51% in optimal conditions after response surface methodology was applied in submerged fermentation. Application of combined immobilized fermentation and extractive fermentation improved productivity to 16.89 U/ml/day, 6.70 times greater than with conservative submerged fermentation. The produced WSYMPs exhibited good tone stability to environmental factors, but their pigment values were unstable to pH, light, and high concentrations of Ca2+, Zn2+, Fe2+, Cu2+, and Mg2+. Furtherly, the produced exYMPs were identified as two yellow monascus pigment components (monascusone B and C21H27NO7S) by UHPLC-ESI-MS. This strategy may be extended to industrial production of premium WSYMPs using Monascus.

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Induction of reproductive cell death in Caenorhabditis elegans across entire linear-energy-transfer range of carbon-ion irradiation

Cited by 6 publications

References 36 publications

Caenorhabditis Elegans as a Model of Radio adaptive Response and Radiation-Induced Bystander Effect

Caenorhabditis Elegans as a Model of Radio adaptive Response and Radiation-Induced Bystander Effect

Review of Biological Effects of Acute and Chronic Radiation Exposure on Caenorhabditis elegans

Increased Water-Soluble Yellow Monascus Pigment Productivity via Dual Mutagenesis and Submerged Repeated-Batch Fermentation of Monascus purpureus

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