Induction of Regulatory T Cells and Indefinite Survival of Fully Allogeneic Cardiac Grafts by Ursodeoxycholic Acid in Mice

Abstract

UDCA induced unresponsiveness to fully allogeneic cardiac allografts and generated CD4+ CD25+ regulatory cells in our model. FK506, but not CyA, was compatible with UDCA treatment.

Elevation of Vδ1 T cells in peripheral blood and livers of patients with primary biliary cholangitis

“…Although gd T cells have been given much more attention in the field of autoimmune diseases, their exact effects in PBC remain unknown. This restoration of the proportion of Vd1 T cells may be attributed to UDCA treatment, which displayed immunosuppressive properties detected in mice [22]. In our study, there was no difference in the percentages of gd T cells between each group, which is similar to Martins et al's study [21].…”

Bile acids and cardiovascular function in cirrhosis

“…The impact on cardiac function has not been well studied but there is evidence that UDCA exerts limited but positive effects on peripheral blood flow in heart failure, prevention of ischaemia‐reperfusion injury and apoptosis, as well as acute cardiac rejection in the post‐transplant setting …”

“…91 The impact on cardiac function has not been well studied but there is evidence that UDCA exerts limited but positive effects on peripheral blood flow in heart failure, 92 prevention of ischaemia-reperfusion injury and apoptosis, 93 as well as acute cardiac rejection in the posttransplant setting. 94 The limited effect of UDCA in cholestatic conditions led to the search for new therapeutic agents. 95 Obeticholic acid (OCA) was synthesized from CDCA as a selective potent FXR agonist with anticholestatic properties.…”

Bile acids induce arrhythmias in human atrial myocardium—implications for altered serum bile acid composition in patients with atrial fibrillation

“…Ursodeoxycholic acid (UDCA), a bile acid that occurs in minor quantities in humans, differs from most other bile acids as it is more hydrophilic and can stimulate bile acid excretion by hepatocytes 15. In fact, UDCA is used therapeutically for various cholestatic disorders and has recently been demonstrated to be beneficial in heart failure in humans,16 in a murine heart transplantation model17 and in a cell culture model of the fetal heart 18…”