Induction of quinone reductase and glutathione in bone marrow cells by 1,2-dithiole-3-thione: Effect on hydroquinone-induced cytotoxicity

Twerdok, Lorranine E.; Rembish, Stephen J.; Trush, Michael A.

doi:10.1016/0041-008x(92)90197-z

Cited by 35 publications

(36 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bone marrow is a target organ for toxicities induced by a spectrum of chemicals (34) including the environmental pollutants benzene and benzo[a]pyrene (BaP) (35). The stromal cell component from bone marrow is particularly susceptible to toxicity induced by several redox-active metabolites of the hematotoxin benzene, such as benzoquinone and HQ (12,28,36). Consequently, it was of great interest when recent studies in our laboratory demonstrated that bone marrow-derived stromal cells could also be protected against hydroquinone-induced cytotoxicity by pretreating cells with the phase II enzyme inducer DTT (12).…”

Section: Discussionmentioning

confidence: 99%

“…Twenty-four hours of pretreatment of stromal cells with 75 ,uM DTT protected against HQ-induced cytotoxicity, even at 95 pM HQ, a concentration that killed all cells in non-DTT-treated controls (12).…”

Section: Resultsmentioning

confidence: 99%

“…The stromal cell component from bone marrow is particularly susceptible to toxicity induced by several redox-active metabolites of the hematotoxin benzene, such as benzoquinone and HQ (12,28,36). Consequently, it was of great interest when recent studies in our laboratory demonstrated that bone marrow-derived stromal cells could also be protected against hydroquinone-induced cytotoxicity by pretreating cells with the phase II enzyme inducer DTT (12). This observation prompted us to further examine whether the inducing activity of DTT in bone marrow stroma also protects against HQ-induced modulation of stromal-dependent myelopoiesis.…”

Section: Discussionmentioning

confidence: 99%

“…""'*..e:---'X' ' 5 stromal element of the bone marrow (5 17-kD cytokine in purified murine bone marrow macrophages (10).~~~~~R ecently it was shown that quinone reductase (QR) activity and glutathione ...(GSH) concentration within stromal cells~~~r eimportant determinants of susceptibility to HQ-induced cytotoxicity (6,11,12 (13,14). In particular, QR catalyzes the two-electron reducof quinones to hydroquinones, which MF:~~~~~~~~~are then amenable to glucuronidation and excretion (15,16 (14,17,18).…”

mentioning

confidence: 99%

“…DeLong and co-workers (19) nature of the induction of GSH and QR activity against HQ-induced cytotoxicity in bone marrow stromal cells (11,12,20).…”

mentioning

confidence: 99%

See 4 more Smart Citations

Studies with 1,2-dithiole-3-thione as a chemoprotector of hydroquinone-induced toxicity to DBA/2-derived bone marrow stromal cells.

Twerdok

Rembish

Trush

1993

Environ Health Perspect

View full text Add to dashboard Cite

Stromal cells from DBA/2 mouse bone marrow have been shown to be susceptible to cytotoxicity induced by several redox-active metabolites of benzene, including hydroquinone (HQ). Treatment with HQ also alters the composition of stromal cell populations by preferentially killing stromal macrophages compared to stromal fibroblasts. This cytotoxicity can be prevented by 1,2-dithiole-3-thione (DTT) as a result of the induction of quinone reductase (QR), a quinone-processing enzyme, and glutathione. The inductive activities of DTT protected stromal cells against HQ-induced cytotoxicity and against HQ-induced impairment of stromal cell ability to support myelopoiesis. In vivo feeding of DTT to DBA/2 mice increased QR activity within the bone marrow compartment and protected bone marrow stromal cells isolated from the DTT-fed animals from ex vivo HQ challenge. Thus, the inducibility of cellular defense mechanisms and xenobiotic-processing enzymes by chemoprotective agents such as DTT may be a useful strategy for protecting against chemically induced bone marrow toxicities.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

“…DeLong and co-workers (19) nature of the induction of GSH and QR activity against HQ-induced cytotoxicity in bone marrow stromal cells (11,12,20).…”

mentioning

confidence: 99%

See 3 more Smart Citations

Studies with 1,2-dithiole-3-thione as a chemoprotector of hydroquinone-induced toxicity to DBA/2-derived bone marrow stromal cells.

Twerdok

Rembish

Trush

1993

Environ Health Perspect

View full text Add to dashboard Cite

show abstract

Phenol and Phenolics

Cavender,

O'Donoghue

2023

Patty's Toxicology

View full text Add to dashboard Cite

The phenolics used for industrial and commercial purposes are a large and diverse group of chemicals as the six‐member ring of phenolics can be methylated, halogenated or include other moieties that add properties or toxicological potential that is not observed with simple phenolics. For simple dihydroxy phenolics, the largest exposure potential can be through their presence naturally in foods. Low concentrations of chlorophenols are commonly found in drinking water due to water chlorination processes. Simple methyl phenols are commonly used as disinfectants. More complex phenolics such as creosote and pentachlorophenol are used as wood preservatives. The acute toxicity of phenolics at relatively high doses is manifested as excitation of the nervous system causing muscle tremors, salivation, and in severe cases, convulsions. The excitatory phase of phenolic intoxication gives way to depression of the nervous system and can result in mortality. Acute and repetitive exposure to phenolics can result in liver and kidney toxicity. A number of phenolics can be absorbed through skin and are readily absorbed after ingestion. Major metabolites of phenols are sulfates and glucuronide conjugates that are excreted through the kidneys. First pass metabolism present on ingestion is not a factor for phenols absorbed through the skin. Therefore, the toxicity of phenolics may differ depending on route of exposure.

show abstract

Phenol and Phenolics

Gingell¹,

O’Donoghue²,

Staab³

et al. 2001

Patty's Toxicology

View full text Add to dashboard Cite

Phenol was originally isolated from coal‐tar streams, but now it is almost exclusively produced by the oxidation of cumene and subsequent cleavage of the cumene hydroperoxide to form phenol and acetone. The U.S. production of phenol for 1995 was 4.16 billion lb (3). Phenol is used in the petroleum industry to extract lube (lubricating) oil from residual oil. It is reacted with aldehydes such as formaldehyde to form “phenolic resins,” which are widely used as adhesives, structural products, and electrical laminates. Other uses include the manufacture of caprolactam (an intermediate in the manufacture of nylon), bisphenol A (an intermediate in the manufacture of epoxy resins and polycarbonates), herbicides, wood preservatives, hydraulic fluids, heavy‐duty surfactants, lube‐oil additives, tank linings and coatings, and intermediates for plasticizers and other specialty chemicals. Phenol is used medically in throat lozenges, disinfectants, and ointments; for facial skin peels; and to cause nerve block. With rare exceptions, human exposure in industry has been limited to accidental contact of phenol with the skin or to inhalation of phenol vapors. Other major sources of inhalation exposure include residential burning and automobile exhaust. Similar details are given for phenolics, including chloro and bromo compounds.

show abstract

Induction of quinone reductase and glutathione in bone marrow cells by 1,2-dithiole-3-thione: Effect on hydroquinone-induced cytotoxicity

Cited by 35 publications

References 21 publications

Studies with 1,2-dithiole-3-thione as a chemoprotector of hydroquinone-induced toxicity to DBA/2-derived bone marrow stromal cells.

Studies with 1,2-dithiole-3-thione as a chemoprotector of hydroquinone-induced toxicity to DBA/2-derived bone marrow stromal cells.

Phenol and Phenolics

Phenol and Phenolics

Contact Info

Product

Resources

About