Induction of proto-oncogene BRF2 in breast cancer cells by the dietary soybean isoflavone daidzein

Koo, Jana; Cabarcas‐Petroski, Stephanie; Petrie, John L.; Diette, N.; White, Robert J.; Schramm, Laura

doi:10.1186/s12885-015-1914-5

Cited by 36 publications

(29 citation statements)

References 63 publications

(66 reference statements)

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“…Daidzein belongs to the family of isoflavones, and is abundant in soybeans and soy-based products; and therefore, may be easily obtained from daily dietary intake (32)(33)(34). Known as a type of phytoestrogen, daidzein has been reported to serve an estrogen-like function in hormone-dependent cells, including prostate cells, breast cells, and Sertoli and Leydig cells of the testes (35)(36)(37). Daidzein exhibits anti-tumor activity, including a pro-apoptotic function in numerous tumor types.…”

Section: Discussionmentioning

confidence: 99%

Daidzein induces choriocarcinoma cell apoptosis in a dose-dependent manner via the mitochondrial apoptotic pathway

Zheng

Sun

et al. 2018

Mol Med Report

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Choriocarcinoma is a malignant gestational trophoblastic disease and relapse or drug resistance occurs in ~25% of gestational trophoblastic tumors. Cell apoptosis serves a role in the progression from hydatidiform mole to persistent gestational trophoblastic disease. It has been demonstrated that daidzein [7‑hydroxy‑3‑(4‑hydroxyphenyl)‑4H‑chromen‑4‑one] may induce apoptosis in a number of cancer types via the mitochondrial apoptotic pathway by altering the B‑cell lymphoma (Bcl)‑2/Bcl‑2 associated X, apoptosis regulator (Bax) ratio, and activating the caspase cascade. Daidzein also serves a role in regulation of production of human chorionic gonadotropin in trophoblast cells and inhibition of cell proliferation. However, few reports have been published regarding the effect of daidzein on apoptosis in choriocarcinoma. Therefore, in the present study, JAR and JEG‑3 human gestational choriocarcinoma cells were used to investigate the effect of daidzein on apoptosis of choriocarcinoma cells. Treatment with daidzein for 48 h reduced cell viability in a dose‑dependent manner. The percentages of early and late apoptotic cells also increased following treatment with daidzein in a dose‑dependent manner, with the number of late apoptotic cells increasing more prominently. Furthermore, treatment with daidzein led to apoptosis‑associated alterations in nuclear morphology of JAR and JEG-3 cells. Expression levels of cleaved poly(ADP‑ribose) polymerase, cleaved caspase‑3 and cleaved caspase‑9 increased following treatment with daidzein, whereas the Bcl‑2/Bax ratio decreased in a dose‑dependent manner. In conclusion, the results of the present study demonstrate that daidzein may induce apoptosis of choriocarcinoma cells in a dose‑dependent manner via the mitochondrial apoptotic pathway.

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Section: Discussionmentioning

confidence: 99%

Daidzein induces choriocarcinoma cell apoptosis in a dose-dependent manner via the mitochondrial apoptotic pathway

Zheng

Sun

et al. 2018

Mol Med Report

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“…This may allow silenced tumour suppressor genes to be re‐expressed, indicating a potential beneficial effect of genistein. However, inhibition of DNMT may also lead to a reduced methylation of proto‐oncogenes, as has been shown for coumestrol, daidzein and equol (Lyn‐Cook et al , ; Koo et al , ), which may indicate a possible adverse effect. However, whether these findings from in vitro studies are relevant for the in vivo situation remains to be established, since genistein has been shown to cause an increase in DNA methylation upon exposure in vivo , such as in the agouti mouse model as mentioned above (Dolinoy et al , ) and in humans (Qin et al , ).…”

Section: Introductionmentioning

confidence: 93%

The potential health effects of dietary phytoestrogens

Rietjens

Louisse

Beekmann

2016

British J Pharmacology

411

246

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Phytoestrogens are plant‐derived dietary compounds with structural similarity to 17‐β‐oestradiol (E2), the primary female sex hormone. This structural similarity to E2 enables phytoestrogens to cause (anti)oestrogenic effects by binding to the oestrogen receptors. The aim of the present review is to present a state‐of‐the‐art overview of the potential health effects of dietary phytoestrogens. Various beneficial health effects have been ascribed to phytoestrogens, such as a lowered risk of menopausal symptoms like hot flushes and osteoporosis, lowered risks of cardiovascular disease, obesity, metabolic syndrome and type 2 diabetes, brain function disorders, breast cancer, prostate cancer, bowel cancer and other cancers. In contrast to these beneficial health claims, the (anti)oestrogenic properties of phytoestrogens have also raised concerns since they might act as endocrine disruptors, indicating a potential to cause adverse health effects. The literature overview presented in this paper illustrates that several potential health benefits of phytoestrogens have been reported but that, given the data on potential adverse health effects, the current evidence on these beneficial health effects is not so obvious that they clearly outweigh the possible health risks. Furthermore, the data currently available are not sufficient to support a more refined (semi) quantitative risk–benefit analysis. This implies that a definite conclusion on possible beneficial health effects of phytoestrogens cannot be made.Linked ArticlesThis article is part of a themed section on Principles of Pharmacological Research of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.11/issuetoc

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“…However, another study reported that daidzein treatment (3–10 μM) up-regulated proto-oncogene BRF2 in ER-positive breast cancer cells but not ER-negative cells. Female mice treated with a high-isoflavone commercial diet showed significantly increased BRF2 expression [129]. …”

Section: Experimental Studiesmentioning

confidence: 99%

Natural Polyphenols for Prevention and Treatment of Cancer

et al. 2016

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There is much epidemiological evidence that a diet rich in fruits and vegetables could lower the risk of certain cancers. The effect has been attributed, in part, to natural polyphenols. Besides, numerous studies have demonstrated that natural polyphenols could be used for the prevention and treatment of cancer. Potential mechanisms included antioxidant, anti-inflammation as well as the modulation of multiple molecular events involved in carcinogenesis. The current review summarized the anticancer efficacy of major polyphenol classes (flavonoids, phenolic acids, lignans and stilbenes) and discussed the potential mechanisms of action, which were based on epidemiological, in vitro, in vivo and clinical studies within the past five years.

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Induction of proto-oncogene BRF2 in breast cancer cells by the dietary soybean isoflavone daidzein

Cited by 36 publications

References 63 publications

Daidzein induces choriocarcinoma cell apoptosis in a dose-dependent manner via the mitochondrial apoptotic pathway

Daidzein induces choriocarcinoma cell apoptosis in a dose-dependent manner via the mitochondrial apoptotic pathway

The potential health effects of dietary phytoestrogens

Natural Polyphenols for Prevention and Treatment of Cancer

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