Induction of proline-rich glycoprotein synthesis in mouse salivary glands by isoproterenol and by tannins.

Mehansho, Haile; Clements, Scott; Sheares, B T; Smith, Stephanie; Carlson, Don M.

doi:10.1016/s0021-9258(18)89281-x

Cited by 150 publications

(26 citation statements)

References 26 publications

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“…Antinutritional effects of polyphenolics have been demonstrated using laboratory animals (Glick and Joslyn, 1970;Myer and Gorbet, 1985;Rostagno et al, 1973) and humans (Hussein and Abbas, 1985;Stavric and Matula, 1992). These effects can be manifested as a decrease in growth rate or feed conversion (Mehansho et al, 1985;Myer and Gorbet, 1985;Rostagno et al, 1973), inhibition of enzymes (Ahmed et al, 1991;Guyot et al, 1996;Oh and Hoff, 1986), and lower egg production (Sell et al, 1983). Diets containing high levels of tannins have been reported to interfere with pancreatic digestion (Driedger and Hatfield, 1972) as well as to cause methionine deficiency by requiring active methyl groups derived from methionine in the detoxification process (Singleton and Kratzer, 1969).…”

Section: Nutritional and Pharmacological Effects Of Food Phenolicsmentioning

confidence: 99%

Phenolics in Food and Nutraceuticals

Shahidi¹,

Naczk

2003

608

426

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has reached the highest academic level, university research professor, in the department of biochemistry at Memorial University of Newfoundland (MUN). He is also cross-appointed to the department of biology, ocean sciences centre and the aquaculture program at MUN. Dr. Shahidi is the author of nearly 500 research papers and book chapters and has authored or edited over 30 books and made over 300 presentations at scientific conferences. His research contributions have led to several industrial developments around the globe. Dr. Shahidi's current research interests include different areas of nutraceuticals and functional foods as well as marine foods and natural antioxidants.Dr. Shahidi serves as the editor-in-chief of the Journal of Food Lipids and is an editorial board member of

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Section: Nutritional and Pharmacological Effects Of Food Phenolicsmentioning

confidence: 99%

Phenolics in Food and Nutraceuticals

Shahidi¹,

Naczk

2003

608

426

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“…Oral application of capsaicin, a pungent ingredient of hot red pepper, produces mucosal inflammation responses, bum sensations, and stimulates salivary secretion (Duner-Engstrom et al, 1986;Green, 1989). Chronic stimulation of the oral mucosa with certain irritants, such as papain (a cysteine protease) and tannic acid, has been reported to induce new constituents (cystatin S, a cysteine protease inhibitor, and proline-rich proteins, tannic acid-binding proteins) in the saliva of rats and mice (Mehansho et al, , 1985Glendinning, 1992;Naito et al, 1992;Ninomiya et al, 1994). When fed diets containing considerable amounts of papain (1.0%) or tannic acid (92.6% as sorghum grains), animals did not consume the required amounts of the diet to maintain or increase body weight at the beginning of feeding.…”

Section: Introductionmentioning

confidence: 99%

Capsaicin Induces Cystatin S-like Substances in Submandibular Saliva of the Rat

Katsukawa

Ninomiya

1999

J Dent Res

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Irritating dietary substances such as tannin and papain have been reported to alter the morphology of salivary glands and their secretions. Such alterations can be one line of protection from toxic or irritating substances in food. We investigated the effects of dietary capsaicin (a pungent ingredient of hot red pepper) on the rat submandibular gland and its secretions. Several groups of animals were offered either control diets or diets containing capsaicin (from 0.0001 to 0.1%) for seven days. Higher concentrations suppressed food consumption for two days, after which only the highest concentration continued to reduce intake. The relative weight of the salivary glands in capsaicin-diet groups increased in a dose-dependent fashion, and new proteins appeared in the submandibular saliva. Chromatographic and electrophoretic properties of these proteins were identical or similar to those of isoproterenol-induced proteins. After affinity chromatography of the new protein fraction on a Cm-papain Sepharose 4B column, SDS-electrophoresis of the eluate revealed three major bands (15,500, 16,500, and 28,000 kDa). Hydrolysis of N-benzoyl-D,L-arginine-p-nitroanilide by papain (a cysteine protease) decreased in the presence of the new protein fraction, suggesting that these proteins have cystatin-like activity (inhibition of cysteine protease). Denervation of the glossopharyngeal nerve suppressed induction of these proteins. The results suggest that dietary capsaicin induces cystatin S-like substances in submandibular saliva by stimulating the reflex arc involving the glossopharyngeal nerve. These proteins likely facilitate ingestion of diets containing the irritating substance.

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“…All of the above mentioned changes could be attributed to the antinutritional effects of polyphenolics which have been demonstrated using laboratory animals (Myer and Gorbet, 1985;Rostagno et al, 1973) and humans (Hussein and Abbas, 1985;Stavric and Matula, 1992). These effects could be manifested as a decrease in growth rate or food metabolism (Mehansho et al, 1985 andMyer andGorbet, 1985;Rostagno et al, 1973), inhibition of enzymes (Ahmed et al, 1991;Guyot et al, 1996;Oh and Hoff, 1986) and lower egg production (Sell et al, 1983).…”

Section: Discussionmentioning

confidence: 94%

Phytochemical analysis of Convolvulus hystrix Vahl and its biological effects in rats

et al. 2013

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"Convolvulus hystrix Vahl" is a plant that has been known to Ancient Egyptians and to Arabs and its root was used traditionally as a purgative. Our attention was directed to the root bark as we observed that the largest part of the plant is deeply impeded underground. The work plan involved testing experimental animals for the influence of aqueous root bark extract on carbohydrate, fat and protein metabolisms as reflected on the growth and relevant laboratory metabolic assessment parameters. Proximate analysis showed high percentages of moisture (85%) and total lipids (7.2%) and surprising amounts of elements such as barium, strontium, rhodium and tellurium (1.7 mg, 3.1 mg, 8 mg and 9.1 mg/g ash, respectively). Random serum glucose value showed a significant decrease in the treated female group (p < 0.05). Serum total proteins of treated female group were found to be increased significantly (p < 0.001), while it was found to be decreased in the relevant treated male group (p < 0.01), together with a significant decrease in blood urea nitrogen (p < 0.05), with a significant increase in the serum creatinine (p < 0.05). Concerning serum fat metabolic parameters, a significant decrease in the serum triglycerides and high-density lipoproteins (p < 0.01 and p < 0.01, respectively) were found. We concluded that the presence of huge amount of polyphenolics such as tannins is responsible for the overall results documented as growth retarding and antinutritional factors. The results were motivating and pointed out to the possible opening of vast areas of research in the field of natural products. We recommend a series of biochemical and pharmacological studies concerning different parts of the plant as well.

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Induction of proline-rich glycoprotein synthesis in mouse salivary glands by isoproterenol and by tannins.

Cited by 150 publications

References 26 publications

Phenolics in Food and Nutraceuticals

Phenolics in Food and Nutraceuticals

Capsaicin Induces Cystatin S-like Substances in Submandibular Saliva of the Rat

Phytochemical analysis of Convolvulus hystrix Vahl and its biological effects in rats

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