Induction of procalcitonin in liver transplant patients treated with anti-thymocyte globulin

Zazula, Roman; Průcha, M; Tyll, Tomáš; Kieslichová, Eva

doi:10.1186/cc6202

Cited by 34 publications

(36 citation statements)

References 17 publications

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“…Cardiac arrest and infection in the donor seem to be associated with high post-OLT PCT levels in the recipient. As underlined before a major limitation as far as the diagnostic accuracy of PCT is concerned stated Zazula et al, who reported the ATG-stimulated elevation of PCT [53]. This aspect was not a limitation of our research, as we prefer ATG-free immunsuppressive regimens.…”

Section: Interpretation Of Our Findingsmentioning

confidence: 76%

“…In adults and children, infection and sepsis have been found to be associated with increased serum levels of calcitonin precursors [46][47][48][49][50][51][52][53]. These concentrations were shown to be positively correlated with a subsequent mortality rate [45].…”

Section: Procalcitonin; Backgroundmentioning

confidence: 99%

“…Procalcitonin (PCT) is a precursor protein of the hormone calcitonin with a molecular weight of approximately 13 kDa. PCT is induced in the plasma of patients with severe bacterial or fungal infections or sepsis [38,[40][41][42][43][44][45][46][47][48][49][50][51][52][53][54]. Local bacterial infections, viral infections, autoimmune and allergic disorders do not induce PCT.…”

Section: Procalcitonin; Backgroundmentioning

confidence: 99%

“…Procalcitonin (PCT) is identified as a diagnostic marker for infectious or septic processes and correlates better with its severity as CRP [5,[44][45][46][47][48][49][50][51][52][53][54][55][56][57]. PCT is an acute phase protein, composed of 116 amino acids and is the precursor of calcitonin.…”

Section: Procalcitonin; Backgroundmentioning

confidence: 99%

“…Furthermore an ATG (antithymocyte globulin)-based immunosuppressive therapy is a stimulus for synthesis and further elevation of PCT [53]. This fact presents the major limitation of PCT's diagnostic power.…”

Section: Pct In Oltmentioning

confidence: 99%

See 4 more Smart Citations

The Role of Procalcitonin in the Early Diagnosis of Septic and Non-Septic Complications in the Immediate Postoperative Setting After Orthotopic Liver Transplantation

Perrakis¹,

Müller²,

Croner³

2012

Sepsis - An Ongoing and Significant Challenge

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Section: Interpretation Of Our Findingsmentioning

confidence: 76%

Section: Procalcitonin; Backgroundmentioning

confidence: 99%

Section: Procalcitonin; Backgroundmentioning

confidence: 99%

Section: Procalcitonin; Backgroundmentioning

confidence: 99%

Section: Pct In Oltmentioning

confidence: 99%

See 3 more Smart Citations

The Role of Procalcitonin in the Early Diagnosis of Septic and Non-Septic Complications in the Immediate Postoperative Setting After Orthotopic Liver Transplantation

Perrakis¹,

Müller²,

Croner³

2012

Sepsis - An Ongoing and Significant Challenge

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Procalcitonin as a prognostic marker for infectious complications in liver transplant recipients in an intensive care unit

et al. 2010

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Clinically significant infections (CSIs) are life-threatening but difficult to diagnose after liver transplantation (LTx). This study investigates the value of procalcitonin (PCT) in addition to c-reactive protein (CRP) and the leukocyte count (LC) as a prognostic marker for CSIs in LTx recipients. The clinical course of 135 LTx recipients was prospectively studied. CSIs were defined as pulmonary, bloodstream, or intra-abdominal infections. Independent risk factors for CSIs were determined by Cox proportional hazard analysis. The concordance statistics (c-statistics) were used to assess the discrimination effect of PCT. Thirty recipients (22%) experienced a CSI. They had significantly higher peak PCT (27.2 versus 12.7 ng/mL, P = 0.014) and peak CRP (13.7 versus 9.9 mg/dL, P < 0.001) and a tendency toward a higher peak LC (19.3 versus 14.2 cells/nL, P = 0.051) in comparison with recipients without CSIs. Independent risk factors for CSIs were male sex [hazard ratio (HR) = 6.4], a body mass index (BMI) < 20 kg/m(2) (versus a BMI > 25 kg/m(2), HR = 13.8), acute liver failure as an indication for LTx (HR = 7.1), a cold ischemic time > 420 minutes (HR = 3.5), and peak CRP (HR = 1.1) but not peak PCT. The addition of peak PCT marginally improved the c-statistic from 0.815 to 0.827. In conclusion, although peak PCT differed significantly between recipients with and without CSIs, it was not an independent risk factor for CSIs and added little prognostic accuracy. Interestingly, the parameters peak CRP, male sex, low BMI, acute liver failure, and long cold ischemic time were independent risk factors for CSIs. They could serve as risk stratifiers directing medical therapy in clinical practice.

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Early Post-operative Care of Liver Transplant Recipient

Gupta¹,

Tomar²

2023

Peri-Operative Anesthetic Management in Liver Transplantation

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Induction of procalcitonin in liver transplant patients treated with anti-thymocyte globulin

Abstract: Introduction The aim of this study was to compare the early postoperative kinetics of procalcitonin (PCT) and C-reactive protein (CRP) serum levels in patients undergoing orthotopic liver transplantation (OLTx) with different immunosuppressive regimens.

Cited by 34 publications

References 17 publications

The Role of Procalcitonin in the Early Diagnosis of Septic and Non-Septic Complications in the Immediate Postoperative Setting After Orthotopic Liver Transplantation

The Role of Procalcitonin in the Early Diagnosis of Septic and Non-Septic Complications in the Immediate Postoperative Setting After Orthotopic Liver Transplantation

Procalcitonin as a prognostic marker for infectious complications in liver transplant recipients in an intensive care unit

Early Post-operative Care of Liver Transplant Recipient

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