Induction of premature labor and delivery by allergic reaction and prevention by histamine H1 receptor antagonist

Bytautiene, Egle; Romero, Roberto; Vedernikov, Yuri P.; El-Zeky, Faten; Saade, George R.; Garfield, Robert E.

doi:10.1016/j.ajog.2004.06.092

Cited by 63 publications

(46 citation statements)

References 15 publications

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“…The following mechanisms of disease have been implicated: 1) intrauterine infection/inflammation ; 2) uterine ischaemia [293][294][295][296][297][298][299][300][301][302][303][304][305][306][307]; 3) uterine overdistension [308][309][310][311][312][313][314][315][316][317][318][319][320][321][322][323][324][325][326][327]; 4) abnormal allogenic recognition [328][329][330][331][332][333][334][335]; 5) allergic-like reaction [336][337][338][339][340]; 6) cervical disease [341,…”

Section: Aetiologies Of the Preterm Parturition Syndromementioning

confidence: 99%

The preterm parturition syndrome and its implications for understanding the biology, risk assessment, diagnosis, treatment and prevention of preterm birth

Gotsch

Romero²,

Erez

et al. 2009

The Journal of Maternal-Fetal & Neonatal Medicine

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117

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Section: Aetiologies Of the Preterm Parturition Syndromementioning

confidence: 99%

The preterm parturition syndrome and its implications for understanding the biology, risk assessment, diagnosis, treatment and prevention of preterm birth

Gotsch

Romero²,

Erez

et al. 2009

The Journal of Maternal-Fetal & Neonatal Medicine

Self Cite

117

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“…Infection accounts, however, for only a fraction of all cases of spontaneous preterm labor. Other pathological processes implicated in the preterm parturition syndrome include cervical insufficiency [19], uterine over-distension [20], abnormal allograft reaction [21], allergy [22,23], endocrine disorders [24][25][26], and vascular insults [27,28]. Indeed, Arias et al [27] reported an excess rate of placental vascular lesions in patients with spontaneous preterm labor.…”

Section: Introductionmentioning

confidence: 99%

Plasma protein Z concentrations in pregnant women with idiopathic intrauterine bleeding and in women with spontaneous preterm labor

Kusanovic

Espinoza

Romero

et al. 2007

The Journal of Maternal-Fetal & Neonatal Medicine

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Objectives. Preterm parturition has been associated with decidual vascular disorders and excessive thrombin generation. The objective of this study was to examine maternal plasma concentrations of protein Z in normal pregnancies, as well as in those presenting with spontaneous preterm labor (PTL) and intrauterine bleeding during pregnancy. Study design. A cross-sectional study was designed to include patients with preterm labor and intact membranes and those with idiopathic intrauterine bleeding during pregnancy. Protein Z plasma concentrations were measured in the following groups: (1) normal pregnant women (n ¼ 71); (2) patients at term with (n ¼ 67) and without labor (n ¼ 88); (3) patients with spontaneous PTL before 34 weeks who were classified into: (a) PTL with intra-amniotic infection/inflammation (IAI; n ¼ 35), (b) PTL without IAI (n ¼ 54), and (c) patients with PTL who delivered at term (n ¼ 49); and (4) patients with idiopathic intrauterine bleeding in the second and third trimester who were divided into: (a) subsequent spontaneous PTL and delivery, and (b) term delivery. Maternal plasma protein Z concentration was measured by a specific and sensitive immunoassay. Moreover, the amniotic fluid concentration of protein Z was determined in a subset of patients with preterm labor (n ¼ 30). Results. (1) There was no correlation between maternal plasma protein Z concentration and gestational age in normal pregnant women. (2) The mean maternal plasma concentration of protein Z was significantly lower in women during spontaneous labor at term than in those not in labor (mean 2.15 mg/mL (95% CI 2.01-2.29) vs. mean 2.45+0.52 mg/mL (95% CI 2.34-2.56), respectively; p ¼ 0.001). (3) Women with PTL without IAI who delivered preterm had a significantly lower mean protein Z concentration than normal pregnant women (mean 2.12 mg/mL (95% CI 1.98-2.26) vs. mean 2.39 mg/ mL (95% CI 2.28-2.5); p ¼ 0.008). (4) Of interest, PTL with IAI was not associated with lower plasma concentrations of protein Z, nor were those with PTL who delivered at term (p 4 0.05 for each). (5) No differences were found in the maternal plasma concentrations of anti-protein Z antibodies between normal pregnancies and those with spontaneous PTL. (6) Patients with idiopathic intrauterine bleeding who had spontaneous PTL and delivery had a significantly lower mean plasma protein Z concentration than those who delivered at term (mean 1.24 mg/mL (95% CI 1.08-1.4) vs. mean 1.49+0.47 mg/mL (95% CI 1.33-1.65), respectively; p ¼ 0.03). (7) Amniotic fluid was found to contain immunoreactive protein Z. Conclusions.(1) Patients with PTL leading to preterm delivery in the absence of IAI had a significantly lower plasma concentration of protein Z than those with normal pregnancies. (2) Patients with idiopathic intrauterine bleeding and subsequently spontaneous PTL and delivery had a significantly lower plasma concentration of protein Z than those with idiopathic intrauterine bleeding who delivered at term. (3) Protein Z was present in the amniotic fluid o...

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“…Notwithstanding, its direct ability to induce PLC activity and hence likely myometrial contractions, bradykinin is also reported to stimulate mast cell degranulation (Heitsch, 2000). Mast cell degranulation releases a plethora of inflammatory mediators, including histamine, which has been reported to induce myometrial contractions via the activation of H 1 histamine receptors (Bytautiene et al, 2004a). Therefore, it is conceivable that bradykinin may have a multifunctional role in the uterus, not only acting as an uterotonin, but might also potentiate the contractile stimuli within the uterus.…”

Section: Discussionmentioning

confidence: 99%

Bradykinin-activated contractile signalling pathways in human myometrial cells are differentially regulated by arrestin proteins

Willets

Brighton

Windell

et al. 2015

Molecular and Cellular Endocrinology

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Bradykinin is associated with infections and inflammation, which given the strong correlation between uterine infection and preterm labour may imply that it could play a role in this process. Therefore, we investigated bradykinin signalling, and the roles that arrestin proteins play in their regulation in human myometrial cells. Bradykinin induced rapid, transient intracellular Ca 2+ increases that were inhibited following B 2 receptor (B 2 R) antagonism.

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Induction of premature labor and delivery by allergic reaction and prevention by histamine H1 receptor antagonist

Cited by 63 publications

References 15 publications

The preterm parturition syndrome and its implications for understanding the biology, risk assessment, diagnosis, treatment and prevention of preterm birth

The preterm parturition syndrome and its implications for understanding the biology, risk assessment, diagnosis, treatment and prevention of preterm birth

Plasma protein Z concentrations in pregnant women with idiopathic intrauterine bleeding and in women with spontaneous preterm labor

Bradykinin-activated contractile signalling pathways in human myometrial cells are differentially regulated by arrestin proteins

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