Induction of preeclampsia like phenomena by stimulation of sympathetic nerve with cold and fasting stress

Chronic Nitric Oxide Synthase Inhibition in Pregnant Rats Does Not Result in Placental Oxidative Stress

“…Another widely used model of rodent preeclampsia is the long term infusion of low doses of lipopolysaccaharide, a potent inflammatory molecule (6). This results in preeclamptic-like symptoms in the rat and it would be interesting see if this is reflected in oxidative changes.…”

“…These include low-dose endotoxin administration (4), sympathetic nervous system stimulation (5,6), uteroplacental ischemia (7), hyperinsulinemia (8), spontaneously hypertensive rat models (9), and nitric oxide inhibition. However, many of these models are of questionable relevance to the human condition because of different placental morphology and poorly characterised changes, both cellular and biochemical, within the placenta.…”

Motivation for motherhood in women with hypertensive diseases in pregnancy

“…There is increasing evidence that psychosocial factors are also directly involved in the etiology of hypertensive diseases in pregnancy [21,22]. Hypertensive diseases are associated with an activation of the sympathetic nervous system [21] and different stressors have been proved to trigger symptoms of hypertensive diseases in pregnancy in animal research [23,24]. Results from interviews with women after a pregnancy complicated by a hypertensive disease support the hypothesis that concepts of motherhood differ in women with hypertensive diseases in pregnancy and women with normal pregnancies.…”

33. Longitudinal changes in serum proinflammatory markers across pregnancy and postpartum: Effects of maternal body mass index

“…Proinflammatory cytokines can promote preterm labor by triggering preterm contractions, encouraging cervical ripening, and causing rupture of the membranes [15,16]. Inflammatory pathways are also implicated in the development of gestational hypertension [17][18][19][20][21][22][23] and gestational diabetes [24]. Moreover, maternal inflammation has been associated with effects on fetal development including risk for neurobehavioral disorders and adverse metabolic changes [25][26][27].…”