2021
DOI: 10.3389/fimmu.2021.637982
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Induction of Potent and Durable Neutralizing Antibodies Against SARS-CoV-2 Using a Receptor Binding Domain-Based Immunogen

Abstract: A novel betacoronavirus (SARS-CoV-2) that causes severe pneumonia emerged through zoonosis in late 2019. The disease, referred to as COVID-19, has an alarming mortality rate and it is having a devastating effect on the global economy and public health systems. A safe, effective vaccine is urgently needed to halt this pandemic. In this study, immunogenicity of the receptor binding domain (RBD) of spike (S) glycoprotein was examined in mice. Animals were immunized with recombinant RBD antigen intraperitoneally u… Show more

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Cited by 9 publications
(5 citation statements)
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“…Our results indicate that anti-SARS-CoV-2 Spike antibodies capable of disrupting the Spike RBD:ACE2 interaction could be detected in all patients followed, suggesting that humoral immunity may persist for long periods. This observation agrees with recent findings 24 .
Figure 6 Evaluation of patient-derived samples from a Brazilian cohort.
…”
Section: Resultssupporting
confidence: 94%
“…Our results indicate that anti-SARS-CoV-2 Spike antibodies capable of disrupting the Spike RBD:ACE2 interaction could be detected in all patients followed, suggesting that humoral immunity may persist for long periods. This observation agrees with recent findings 24 .
Figure 6 Evaluation of patient-derived samples from a Brazilian cohort.
…”
Section: Resultssupporting
confidence: 94%
“…Several vaccines (Sputnik V, AZD1222, and BBIBP‐CorV) have entered phase-III clinical trials [ 69 ]. Recent studies demonstrated that Zn-chitosan can induce the generation of effective and durable neutralizing antibodies against SARS-CoV-2 as a promising vaccine candidate; however, additional immunological and structural studies at the monoclonal antibody level are required [ 70 ]. Zinc blocks the replication of 2019-nCoV by inhibiting viral replication and regulating immunity, and zinc supplements have clinical value for preventing and treating COVID-19.…”
Section: Protective Role Of Zinc In Respiratory Diseasesmentioning
confidence: 99%
“…For this purpose, we included a single glycan at Asn343 in the RBD, since this is the only Spike glycan that is spatially located near the RBD-ACE2 interface. Moreover, by focusing on local energetic factors for the RBD-ACE2 complex, we provide a theoretical basis that may guide the design of extracellular ACE2 domain as decoy to neutralize viral infection [18,19], and aid the study of RBD immunogens that can lead to potent neutralizing antibody induction [20,21].…”
Section: Introductionmentioning
confidence: 99%