2010
DOI: 10.1007/s12031-010-9393-2
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Abstract: Fibroblast growth factor has been implicated in cerebral cortical cell proliferation, migration, survival and differentiation. In the nervous system, proteoglycans (PGs) modulate growth factor activities and cell proliferation. Perlecan is a large PG and is expressed during the prenatal stages of brain development. Perlecan can promote fibroblast growth factor-2 (FGF-2) activity. In this study the effects of FGF-2 on neurogenesis and perlecan expression in the cerebral cortex have been studied. FGF-2 and anti-… Show more

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Cited by 7 publications
(5 citation statements)
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References 30 publications
(33 reference statements)
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“…Specific core proteins also play major roles in neurogenesis. The expression of perlecan is increased in response to Fgf2 ( Mashayekhi et al, 2011 ), and mice lacking perlecan (Hspg2 – Mouse Genome Informatics) show reduced cell proliferation leading to microcephaly with thinner cerebral walls ( Girós et al, 2007 ). Perlecan is also required for the maintenance of NSCs, as both the size of the NSC population and the extent of neurogenesis are strongly reduced in the SVZ of adult mice lacking perlecan ( Kerever et al, 2014 ).…”
Section: Roles For Hspgs During Nervous System Developmentmentioning
confidence: 99%
“…This FGF-2 will likely be bound to perlecan in the lens capsule, which not only protects FGF-2 from degradation, but also regulates its availability to the lens epithelial cells ( Evans et al., 2002; Tumova and Bame, 1997 ). HSPGs are also established regulators of morphogen gradients ( Giraldez et al., 2002 ), but FGF-2 can also influence HSPG processing ( Sasisekharan et al., 1997; Tumova and Bame, 1997; Tumova et al., 1999 ) and can also increase HSPG synthesis ( Evans et al., 2002; Mashayekhi et al., 2011 ) as a feedback loop that could further regulate the levels of FGF-2. Such issues have yet to be investigated for the lens capsule.…”
mentioning
confidence: 99%
“…In early CP development, FGF expression, particularly FGF2, modulates gene expression and activity, suggesting that FGF signaling maintains CP integrity and function (Greenwood et al, 2008). Secreted FGF2 has also been shown to have a role in the developing brain by regulating cell proliferation/neurogenesis and corticogenesis (Vaccarino et al, 1999;Mashayekhi et al, 2011).…”
Section: Impact Of Choroid Plexus Trophic Factors In the Developing Bmentioning
confidence: 99%
“…Cytokines and growth factor play important roles in brain development and function [14,15]. Growth factor expression could participate in the repair process of demyelinating disease by modulating the activity of microglia/macrophages, inducing the expression of other factors that can affect myelin regeneration or degeneration, and also by directly stimulating the localized proliferation and/or regen eration of oligodendrocytes within lesion areas [21].…”
Section: Introductionmentioning
confidence: 99%
“…Estos investigadores encontraron también que la deficiencia de perlecán (ratones Hspg-/-Tg) ocasiona una significativa disminución en el número de NPCs quiescentes y activadas, así como una disminución en el número de nuevas neuronas que se integran en el bulbo olfatorio. También se ha mostrado que la administración de FGF2 en ratones recién nacidos, a través de la cisterna magna, incrementó a las 48 horas la producción de perlecán a nivel cortical y la proliferación de precursores que expresan marcadores neuronales, así como un aumento en el grosor de la corteza cerebral, mientras que la infusión de anticuerpo anti-FGF2 logró el efecto opuesto [Mashayekhi et al, 2011]. Un efecto de sobreexpresión de glipicano-6 en tejido cerebral fue obtenido por otros investigadores en experimentos similares de inyección de FGF2 en la cisterna magna de ratones recién nacidos [Salehi Z., 2009].…”
Section: Heparán Sulfato Proteoglicanos Y Su Regulación De La Actividunclassified