Induction of paraoxon dealkylation by hexachlorobenzene (HCB) and mirex

Interaction between .gamma.-hexachlorocyclohexane and the gastrointestinal microflora and their effect on the absorption, biotransformation, and excretion of parathion by the rat

“…While a reduced initial excretion rate would be expected due to the relatively slower absorption of parathion through the skin, the decreased initial excretion rate observed in the lindanepretreated rats was unexpected. Lindane induces hepatic mixed function oxidases (Kolmodin-Hedman et al, 1971; Chadwick et al, 1971;Den Tonkelaar and Van Esch, 1974;Mikol et al, 1980) and, if anything, might be expected to increase the excretion rate. Moreover, increases in the metabolism of paraoxon by mixed function oxidases have been cited as a mechanism by which halogenated compounds antagonize the toxicity of parathion (Townsend and Carlson, 1981;Iverson, 1976).…”

“…Lindane induces hepatic mixed function oxidases (Kolmodin-Hedman et al, 1971; Chadwick et al, 1971;Den Tonkelaar and Van Esch, 1974;Mikol et al, 1980) and, if anything, might be expected to increase the excretion rate. Moreover, increases in the metabolism of paraoxon by mixed function oxidases have been cited as a mechanism by which halogenated compounds antagonize the toxicity of parathion (Townsend and Carlson, 1981;Iverson, 1976). Thus, the effect of lindane pretreatment on the metabolism of parathion was next examined.…”

Effects of dietary hexachlorobenzene on in vivo biotransformation, residue deposition, and elimination of certain xenobiotics by rats

“…Because HCB is an environmental contaminant of significance and is a potent inducer of the hepatic mixed function oxidase enzyme systems, (Rajamanickam and Padmanaban, 1974; Stonard and Nenov, 1974; Turner and Green, 1974; Koss and Koransky, 1975; Mehendale et al, 1975;Stonard, 1975; Iverson, 1976), we need to obtain information regarding its interactions with various components of the environment. The current study was undertaken to evaluate certain aspects of the interactions of HCB with mammals: specifically, its effects on in vivo biotransformation, residue deposition, and excretion of certain other chemicals by the laboratory rat.…”