Induction of oxidative stress in paraquat formulating workers

Ranjbar, Akram; Pasalar, Parvin; Sedighi, Alireza; Abdollahi, Mohammad

doi:10.1016/s0378-4274(02)00033-4

Cited by 48 publications

(24 citation statements)

References 13 publications

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“…Several pathways were clarified as pathways of oxidative injuries by PQ including: reduction of PQ by NADPH-cytochrome P450 reeducates and a subsequent redox cycle, inhibition of mitochondrial electron transport chain, and interaction with nitric oxide syntheses, NADPH oxidase and xanthine oxidase (Ranjbar et al, 2002). Another report showed that PQ enhanced expression of iNOS in aortic endothelial cells and consequently increased the NO production leading to the decreased responsiveness of aortas to vasoconstrictors (Aires et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Atorvastatin protected from paraquat-induced cytotoxicity in alveolar macrophages via down-regulation of TLR-4

Alizadeh-Tabrizi

Malekinejad

Varasteh

et al. 2017

Environmental Toxicology and Pharmacology

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a b s t r a c tThe current study designed to clarify the mechanism of paraquat-induced cytotoxicity and protective effects of Atorvastatin on freshly isolated alveolar macrophages (AMs). AMs were collected via bronchoalveolar lavage and exposed to various concentrations of paraquat in the presence and absence of atorvastatin for 24 h. Cell viability, myeloperoxidase activity; nitric oxide generation and total antioxidant capacity were assessed. Expression of TLR-4 at mRNA and protein levels were studied by using PCR and western blot methods Atorvastatin enhanced the paraquat-reduced cell viability and reduced the paraquat-induced myeloperoxidase activity and nitric oxide production. Moreover, atorvastatin downregulated by 60% the paraquat up-regulated expression of TLR-4 at protein and mRNA level. Our results suggest that, AMs in vitro model could be a novel cytological tool for studies on paraquat poisoning and therapy regimens. Additionally, atorvastatin cytoprotective effects on paraquat-induced cytotoxicity partly attribute to its anti-myeloperoxidase, antioxidant properties, which might be regulated via TLR-4 expression.

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Section: Discussionmentioning

confidence: 99%

Atorvastatin protected from paraquat-induced cytotoxicity in alveolar macrophages via down-regulation of TLR-4

Alizadeh-Tabrizi

Malekinejad

Varasteh

et al. 2017

Environmental Toxicology and Pharmacology

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“…Intravenous infusions of cyclophosphamide (15 mg/kg) daily for two days and methylprednisolone 1 g daily for three days decreased the mortality rate of paraquat poisoning by 33.3% (43). In a chronic exposure study on paraquat-formulators, increased LPO and decreased antioxidant power were reported (44). …”

Section: Reultsmentioning

confidence: 99%

Environmental and Population Studies Concerning Exposure to Pesticides in Iran: A Comprehensive Review

Mostafalou¹,

Karami‐Mohajeri²,

Abdollahi³

2013

Iran Red Cres Med J

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Pesticides are widely used in Iranian agriculture and this has made a major toxicological concern among health professionals. The objective of this study is to explore national data about pesticides toxicity. All relevant databases such as Google Scholar, PubMed, and Scopus in a time period of 1960 to 2012 were searched for the keywords “Pesticides, Iran, Environment, and Population studies”. A total of 57 studies were found relevant and then included into study. Almost all non-experimental studies carried out in Iran were classified into two main categories of residue assessment in different samples and toxic effects on human. Depending on the dose and duration of exposure, toxic effects of pesticides have been studied in two classifications including acute toxicity or acute poisoning and chronic toxicity. High extent of pesticides have been used during the past decade in Iran while no enough proper studies were done to explore their possible toxic effects in the environment and the people.

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“…Nas plantas, o paraquat exerce sua atividade herbicida por interferir no sistema intracelular de transferência de elétrons, inibindo a redução de NADP a NADPH durante a fotossíntese, quando os radicais superóxido (O 2 -), oxigênio singlete (O 2 * ), hidroxila (OH -) e peróxido de hidrogênio (H 2 O 2 ) são formados nas plantas (RANJBAR et al, 2002). Este processo leva à destruição dos lipídios das membranas celulares pela polimerização de compostos lipídicos insaturados (SANDY et al, 1986).…”

Section: Toxicodinâmicaunclassified