Induction of oxidative stress and apoptosis by silver nanoparticles in the liver of adult zebrafish

Choi, Ji Eun; Kim, Soohee; Ahn, Jin Hee; Youn, Pilju; Kang, Jin Seok; Park, Kwangsik; Yi, Jongheop; Ryu, Doug-Young

doi:10.1016/j.aquatox.2009.12.012

Cited by 447 publications

(262 citation statements)

References 51 publications

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“…Silver nanoparticles are also known for genotoxicity and cytotoxicity in fish including accumulation in gill tissues and lysosomal destabilization in adult oysters. They are also known for adverse effects on oyster embryonic development, oxidative stress and expression of p53 protein in zebrafish [187,[199][200][201][202]. In another study conducted on zebrafish, it was observed that silver nanoparticles caused induction of apoptosis and oxidative stress in the liver.…”

Section: Mechanistic Studiesmentioning

confidence: 99%

“…In another study conducted on zebrafish, it was observed that silver nanoparticles caused induction of apoptosis and oxidative stress in the liver. After nanoparticles' treatment, there was upregulation of the p53-related pro-apoptotic genes Noxa, Bax and p21 [200]. Oyster embryo was used to examine the toxic effects of silver nanoparticles on embryonic development.…”

Section: Mechanistic Studiesmentioning

confidence: 99%

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In vitro and in vivo toxicity assessment of nanoparticles

2017

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Nanotechnology has revolutionized gene therapy, diagnostics and environmental remediation. Their bulk production, uses and disposal have posed threat to the environment. With the appearance of these nanoparticles in the environment, their toxicity assessment is an immediate concern. This review is an attempt to summarize the major techniques used in cytotoxity determination. The review also presents a detailed and elaborative discussion on the toxicity imposed by different types of nanoparticles including carbon nanotubes, gold nanoparticles, silver nanoparticles, quantum dots, fullerenes, aluminium nanoparticles, zinc nanoparticles, iron nanoparticles, titanium nanoparticles and silica nanoparticles. It discusses the in vitro and in vivo toxological effects of nanoparticles on bacteria, microalgae, zebrafish, crustacean, fish, rat, mouse, pig, guinea pig, human cell lines and human. It also discusses toxological effects on organs such as liver, kidney, spleen, sperm, neural tissues, liver lysosomes, spleen macrophages, glioblastoma cells, hematoma cells and various mammalian cell lines. It provides information about the effects of nanoparticles on the gene-expression, growth and reproduction of the organisms.

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Section: Mechanistic Studiesmentioning

confidence: 99%

Section: Mechanistic Studiesmentioning

confidence: 99%

In vitro and in vivo toxicity assessment of nanoparticles

2017

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“…When the embryos of zebrafish were injected with artificial noxa mRNA, cell apoptosis was observed and the apoptosis was dose-dependent [12]. A significantly up-regulation of noxa mRNA was found in the zebrafish liver cells apoptosis [12,20].…”

Section: Introductionmentioning

confidence: 99%

Expression pattern and transcriptional regulatory mechanism of noxa gene in grass carp (Ctenopharyngodon idella)

Pei

Lü

et al. 2015

Fish & Shellfish Immunology

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“…The estimated concentrations in sludge-treated soils of nano-TiO 2 and nano-silver are 42 μg/kg and 662 ng/kg per year, respectively (Gottschalk et al, 2009). Ecological concerns increase due to the antimicrobial/toxic effects of nano-silver and TiO 2 (Choi et al, 2010;Yang et al, 2012a,b), which could inhibit a wide range of microorganisms in the soil environment (Ge et al, 2011;U.S. EPA, 2010;Yang et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Metal and nanoparticle occurrence in biosolid-amended soils

Yang

Wang

Westerhoff

et al. 2014

Science of The Total Environment

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• Biosolid land application increased the unregulated metal contents in surface soil.• Metals (e.g., Ag) associated with ENMs show accumulation and low mobility in soils.• Titanium-containing nanoparticle (50 nm in diameter) was identified in the soils. Metals can accumulate in soils amended with biosolids in which metals have been concentrated during wastewater treatment. The goal of this study is to inspect agricultural sites with long-term biosolid application for a suite of regulated and unregulated metals, including some potentially present as commonly used engineered nanomaterials (ENMs). Sampling occurred in fields at a municipal and a privately operated biosolid recycling facilities in Texas. Depth profiles of various metals were developed for control soils without biosolid amendment and soils with different rates of biosolid application (6.6 to 74 dry tons per hectare per year) over 5 to 25 years. Regulated metals of known toxicity, including chromium, copper, cadmium, lead, and zinc, had higher concentrations in the upper layer of biosolid-amended soils (top 0-30 cm or 0-15 cm) than in control soils. The depth profiles of unregulated metals (antimony, hafnium, molybdenum, niobium, gold, silver, tantalum, tin, tungsten, and zirconium) indicate higher concentrations in the 0-30 cm soil increment than in the 70-100 cm soil increment, indicating low vertical mobility after entering the soils. Titanium-containing particles between 50 nm and 250 nm in diameter were identified in soil by transmission electron microscopy (TEM) coupled with energy dispersive x-ray spectroscopy (EDX) analysis. In conjunction with other studies, this research shows the potential for nanomaterials used in society that enter the sewer system to be removed at municipal biological wastewater treatment plants and accumulate in agricultural fields. The metal concentrations observed herein could be used as representative exposure levels for eco-toxicological studies in these soils. a b s t r a c t a r t i c l e i n f o

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Induction of oxidative stress and apoptosis by silver nanoparticles in the liver of adult zebrafish

Cited by 447 publications

References 51 publications

In vitro and in vivo toxicity assessment of nanoparticles

In vitro and in vivo toxicity assessment of nanoparticles

Expression pattern and transcriptional regulatory mechanism of noxa gene in grass carp (Ctenopharyngodon idella)

Metal and nanoparticle occurrence in biosolid-amended soils

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