Induction of ovulation in the human with human gonadotropins

Buxton, C. Lee; Herrmann, Walter

doi:10.1016/s0002-9378(15)33673-5

Cited by 61 publications

(12 citation statements)

References 3 publications

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“…However, insofar as female macaques are concerned, ovulation can be induced more consistently by homologous pituitary gonadotropin preparations (Simpson and van Wagenen [1963]). Such preferential response of the ovary to homologous gonadotrpins is also probably true for the human (Gemzell [1961]; Buxton and Herrman [1961]). …”

Section: Response Of the Ovary Of Prepureral Langoors (Presbytis Entementioning

confidence: 85%

Response of the Ovary of Prepuberal Langoors (Presbytis Entellus) to Heterologous Mammalian Gonadotropins

Kar¹,

Chandra²

1965

Cells Tissues Organs

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Section: Response Of the Ovary Of Prepureral Langoors (Presbytis Entementioning

confidence: 85%

Response of the Ovary of Prepuberal Langoors (Presbytis Entellus) to Heterologous Mammalian Gonadotropins

Kar¹,

Chandra²

1965

Cells Tissues Organs

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“…Buxton and his colleagues at Yale University confirmed Gemzell’s work in the United States in 1960 ( 5 ). In their work, induction of ovulation was accomplished using pituitary extracts, which had primarily FSH activity, and hCG as a substitute for LH.…”

Section: Isolation and Purification Of Gonadotropinsmentioning

confidence: 92%

History and challenges surrounding ovarian stimulation in the treatment of infertility

Beall

DeCherney

2012

Fertility and Sterility

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OBJECTIVE To examine the history of superovulation for ovulation induction, its contributions to reproductive medicine and its impact on multiple births. DESIGN A search of the relevant literature using Pubmed and other online tools. RESULT(S) Infertility has been a condition known and studied for thousands of years. However, it was not until this past century that effective treatments were developed. With the advancement of our knowledge of the hypothalamic-pituitary axis, therapies utilizing gonadotropins were developed to stimulate ovulation. Not only were we now able to treat anovulatory infertility, but also induce superovulation for in vitro fertilization. With these successes came consequences, including increased multiple pregnancies. Several countries recognized the high costs associated with multiple births and implemented regulations on the infertility industry. The rate of triplet and higher-order multiples has declined over the past decade. This is largely attributed to a decreased number of embryos transferred. Nonetheless, the twin rate has remained consistently high. CONCLUSION(S) Superovulation has become a routine medical therapy used for ovulation induction and in vitro fertilization. With the development of this technology have come effective therapies for infertility and new ethical and medical challenges. Since the advent of gonadotropin therapy we have already developed technologies to improve monitoring and decrease hyperstimulation and high order multiple pregnancies. In the future, we anticipate new tools devised to optimize one embryo for one singleton live birth.

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“…The concept of using PMSG, hog or sheep pituitary gonadotropins to stimulate follicular development and hCG to trigger ovulation (two-step protocol) was introduced in 1941 [72]. Pituitary animal extracts and PMSG were used in both Europe and the USA until the early 1960s, despite the findings that such treatments resulted in the production of neutralizing antibodies (antihormones), which rendered the ovaries unresponsive to repeated stimulation [2,3,73].…”

Section: Discovery Of Hcg Pmsg and Animal Pituitary Extractsmentioning

confidence: 99%