Induction of new metabolites from sponge-associated fungus Aspergillus carneus by OSMAC approach

Özkaya, Ferhat Can; Ebrahim, Weaam; El-Neketi, Mona; Tanrıkul, T. Tansel; Kalscheuer, Rainer; Müller, Wernér E.G.; Guo, Zhiyong; Zou, Kun; Liu, Zhen; Proksch, Peter

doi:10.1016/j.fitote.2018.10.008

Cited by 37 publications

(24 citation statements)

References 25 publications

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“…Supplementary Materials: LC-MS/MS molecular networking figure showing prioritization of the title strain, 1 H NMR, 13 C NMR, DEPT135, 1 H-1 H COSY, HSQC, HMBC, and NOESY spectra for compounds 1-2, X-ray crystallographic data of 1 and 2 (CIF) and supplementary materials for ECD calculation are available online at https://www.mdpi.com/article/10.3390/md19040186/s1.…”

Section: Discussionmentioning

confidence: 99%

“…The term "holobiont" is used to describe multilevel assemblages of organisms composed, for example, of a sponge and associated microbiota (up to 40% of sponge volume), including fungi, yeast, and bacteria [7][8][9][10]. Sponge-associated fungi have produced many intriguing molecules reported with conspicuous pharmacological and biological properties, exemplified by antimicrobial [11][12][13], cytotoxic [13,14], anti-viral [15,16], antifungal [17], anti-inflammatory [18], and α-glucosidase inhibitory [19] activities. However, a vast quantity of sponge-derived fungal biodiversity remains uninvestigated, suggesting that many natural product metabolites also remain to be discovered.…”

Section: Introductionmentioning

confidence: 99%

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Cytotoxic Polyketide Metabolites from a Marine Mesophotic Zone Chalinidae Sponge-Associated Fungus Pleosporales sp. NBUF144

Zhou

Zhang

et al. 2021

Marine Drugs

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Two new polyketide natural products, globosuxanthone F (1), and 2′-hydroxy bisdechlorogeodin (2), were isolated from the fungus Pleosporales sp. NBUF144, which was derived from a 62 m deep Chalinidae family sponge together with four known metabolites, 3,4-dihydroglobosuxanthone A (3), 8-hydroxy-3-methylxanthone-1-carboxylate (4), crosphaeropsone C (5), and 4-megastigmen-3,9-dione (6). The structures of these compounds were elucidated on the basis of extensive spectroscopic analysis, including 1D and 2D NMR and high-resolution electrospray ionization mass spectra (HRESIMS) data. The absolute configuration of 1 was further established by single-crystal X-ray diffraction studies. Compounds 1-5 were evaluated for cytotoxicity towards CCRF-CEM human acute lymphatic leukemia cells, and it was found that 1 had an IC50 value of 0.46 µM.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cytotoxic Polyketide Metabolites from a Marine Mesophotic Zone Chalinidae Sponge-Associated Fungus Pleosporales sp. NBUF144

Zhou

Zhang

et al. 2021

Marine Drugs

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“…Gymnastatin B had moderate cytotoxic activity with an IC50 value of 5.8 µM. Three natural products isolated from Aspergillus carneus, isopropylchetominine, sterigmatocystin, and astelotoxin E showed significant cytotoxicity against mouse lymphoma cell L5178Y (IC50 0.04, 0.3, and 0.2 µM, respectively) [23]. Bromophilone B isolated from sponge-associated fungus Penicilliun canescens displayed cytotoxicity against L5178Y, a mouse lymphoma cell line (IC50 8.9 µM) [24].…”

Section: Microorganism-derived Compounds and Lymphomamentioning

confidence: 99%

Review of Natural Compounds for the Management and Prevention of Lymphoma

et al. 2020

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Lymphoma is a type of blood cancer that can be categorized into two types-Hodgkin lymphoma (HL) and Non-Hodgkin lymphoma (NHL). A total of 509,590 and 79,990 cases of NHL and HL were newly diagnosed in 2018, respectively. Although conventional therapy has stridden forward over recent decades, its adverse effects are still a hurdle to be solved. Thus, to help researchers develop better lymphoma treatment, this study aims to review the systematic anticancer data for natural products and their compounds. A variety of natural products showed anticancerous effects on lymphoma by regulation of intracellular mechanisms including apoptosis as well as cell cycle arrest. As these results shed light on the potential to substitute conventional therapy with natural products, it may become a promising strategy for lymphoma treatment in the near future.

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“…The study of possible modifications in the metabolism of this microorganism on a culture medium is a contribution to the one strainmany compounds (OSMAC) approach, which aims at the production of new substances through the awakening of silenced genes. [16][17][18][19][20]…”

Section: Introductionmentioning

confidence: 99%

Biosorption Potential of the Aspergillus sp. and Insights into Secondary Metabolism in the Presence of Copper and Lead

Alves

Silva

et al. 2020

J. Braz. Chem. Soc.

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The fungus Aspergillus sp. was isolated from copper mining rejects and cultured in a liquid culture medium (potato dextrose, PD) enriched with CuSO 4 .5H 2 O and Pb(NO 3) 2 in different concentrations. By flame atomic absorption spectrometry (FAAS) it was observed that fungus absorbed 86% of both copper and lead, with initial concentrations of 100, 500 and 1000 mg L-1. The additional results provided by scanning electron microscopy, energy dispersive spectroscopy, and X-ray diffraction showed ability of the microorganism to act as a biosorbent as well as its capacity to transform the tested salts into other inorganic compounds. Chromatographic profile comparison of extracts obtained from the biotic, abiotic control and the cultivation enriched with the metals showed changes in the profile of the secondary metabolism. When the copper and lead salts were tested separately, there was an increase in the production of the compounds as function of the increase of the concentration and when associated promoted the decrease and disappearance of some substances produced by Aspergillus sp.

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Induction of new metabolites from sponge-associated fungus Aspergillus carneus by OSMAC approach

Cited by 37 publications

References 25 publications

Cytotoxic Polyketide Metabolites from a Marine Mesophotic Zone Chalinidae Sponge-Associated Fungus Pleosporales sp. NBUF144

Cytotoxic Polyketide Metabolites from a Marine Mesophotic Zone Chalinidae Sponge-Associated Fungus Pleosporales sp. NBUF144

Review of Natural Compounds for the Management and Prevention of Lymphoma

Biosorption Potential of the Aspergillus sp. and Insights into Secondary Metabolism in the Presence of Copper and Lead

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