Induction of New Lactam Derivatives From the Endophytic Fungus Aplosporella javeedii Through an OSMAC Approach

Gao, Ying; Stuhldreier, Fabian; Schmitt, Laura A.; Wesselborg, Sebastian; Guo, Zhiyong; Zou, Kun; Mándi, Attila; Kurtán, Tibor; Liu, Zhen; Proksch, Peter

doi:10.3389/fmicb.2020.600983

Cited by 11 publications

(5 citation statements)

References 48 publications

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“…Potato dextrose agar (PDA) media was developed through OSMAC to produce a new secondary metabolite (eight indole diketopiperazines, five quinazolinone alkaloids and three helvolic acid) by endophytic A. fumigatus which isolated from Astragalus membranaceus [ 141 ]. Moreover, solid rice medium which includes inducer compounds (NaNO 3 or monosodium glutamate) led to produce eleven new lactam derivatives, pramanicin A and aplosporellins A-K from endophytic Aplosporella javeedii through OSMAC method [ 142 ]. Furthermore, kojic acid was produced from endophytic A. flavus which isolated from leaves of Annona squamosal by OSMAC strategy on different cultivation media (rice media, sweet and waxy corn media), this can be used in many applications in medical, cosmetic and industry [ 143 ].…”

Section: Enhancement Of Secondary Metabolites Biosynthesis In Fungal ...mentioning

confidence: 99%

Bioactive compounds and biomedical applications of endophytic fungi: a recent review

Hashem,

Attia,

Kandil

et al. 2023

Microb Cell Fact

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Human life has been significantly impacted by the creation and spread of novel species of antibiotic-resistant bacteria and virus strains that are difficult to manage. Scientists and researchers have recently been motivated to seek out alternatives and other sources of safe and ecologically friendly active chemicals that have a powerful and effective effect against a wide variety of pathogenic bacteria as a result of all these hazards and problems. In this review, endophytic fungi and their bioactive compounds and biomedical applications were discussed. Endophytes, a new category of microbial source that can produce a variety of biological components, have major values for study and broad prospects for development. Recently, endophytic fungi have received much attention as a source for new bioactive compounds. In addition, the variety of natural active compounds generated by endophytes is due to the close biological relationship between endophytes and their host plants. The bioactive compounds separated from endophytes are usually classified as steroids, xanthones, terpenoids, isocoumarins, phenols, tetralones, benzopyranones and enniatines. Moreover, this review discusses enhancement methods of secondary metabolites production by fungal endophytes which include optimization methods, co-culture method, chemical epigenetic modification and molecular-based approaches. Furthermore, this review deals with different medical applications of bioactive compounds such as antimicrobial, antiviral, antioxidant and anticancer activities in the last 3 years.

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Section: Enhancement Of Secondary Metabolites Biosynthesis In Fungal ...mentioning

confidence: 99%

Bioactive compounds and biomedical applications of endophytic fungi: a recent review

Hashem,

Attia,

Kandil

et al. 2023

Microb Cell Fact

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“…TE-540 [ 213 ], mutolide [ 234 ] and pramanicin A from Aplosporella j . [ 216 ], myrothecines H and I from Paramyrothecium r . A697 [ 217 ], and colletotrichalactone A and colletotrichalactone Ca from Colletotrichum spp.…”

Section: Anticancer Activity Of Endophytic Fungimentioning

confidence: 99%

Putative Anticancer Compounds from Plant-Derived Endophytic Fungi: A Review

et al. 2022

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Endophytic fungi are microorganisms that exist almost ubiquitously inside the various tissues of living plants where they act as an important reservoir of diverse bioactive compounds. Recently, endophytic fungi have drawn tremendous attention from researchers; their isolation, culture, purification, and characterization have revealed the presence of around 200 important and diverse compounds including anticancer agents, antibiotics, antifungals, antivirals, immunosuppressants, and antimycotics. Many of these anticancer compounds, such as paclitaxel, camptothecin, vinblastine, vincristine, podophyllotoxin, and their derivatives, are currently being used clinically for the treatment of various cancers (e.g., ovarian, breast, prostate, lung cancers, and leukemias). By increasing the yield of specific compounds with genetic engineering and other biotechnologies, endophytic fungi could be a promising, prolific source of anticancer drugs. In the future, compounds derived from endophytic fungi could increase treatment availability and cost effectiveness. This comprehensive review includes the putative anticancer compounds from plant-derived endophytic fungi discovered from 1990 to 2020 with their source endophytic fungi and host plants as well as their antitumor activity against various cell lines.

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“…A bacterium cannot be determined based only on its morphological properties, so it is necessary to see the biochemical properties and factors that affect its growth. Five biochemical tests were carried out: catalase, starch hydrolysis, citrate, Sulphate Indole Motility, and gelatin hydrolysis (Gao et al, 2020) (Rosalina et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Isolation, Identification, and Antibacterial Assay of Indigenous Bacterial Isolates from Apis cerana Honeycomb

Simbolon,

Mokosuli,

Lawalata

2023

JPBN

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Apis cerana is a honey bee species with a cavity hive known as the eastern honey bee. Honey bee hives have Indigenous bacteria that have antimicrobial potential. Indigenous bacteria are free bacteria that can synthesize nitrogen compounds, sugars, and other bioactive substances. This study aims to isolate, identify and test the antibacterial of Indigenous bacteria isolate Apis cerana against gram-positive Staphylococus aureus and gram-negative bacteria Escherichia coli. This study used a descriptive research method to obtain the data from laboratory experiments. The study consisted of isolating Indigenous bacteria, identifying and testing the antibacterial agar diffusion method. The study results obtained seven isolates of AC 1, AC 2, AC 3, AC 4, AC 5, AC 6, AC 7 Indigenous bacteria from Apis cerana nests. AC 1 isolate has similarities with the genus Streptococcus, AC 2 isolates have similarities with the Klebsiella genus, while AC 3 isolates have similarities with the Bacillus genus, and AC 4, AC 5, AC 6 and AC 7 isolates have similarities with the Citrobacter genus. Indigenous bacterial isolates with potential antibacterial potential where the most significant inhibition against Staphylococus aureus bacteria was shown by isolate AC 1 (10.79 mm). At the same time, the smallest was found in isolate AC 7 (8.52 mm). The most significant inhibition against Escherichia coli bacteria was shown by isolate AC 1 (9.0 mm) while the smallest was found in isolate AC 3 (7.4 mm). Apis cerana nests have indigenous bacteria that have the potential to produce antibacterial substances

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Induction of New Lactam Derivatives From the Endophytic Fungus Aplosporella javeedii Through an OSMAC Approach

Cited by 11 publications

References 48 publications

Bioactive compounds and biomedical applications of endophytic fungi: a recent review

Bioactive compounds and biomedical applications of endophytic fungi: a recent review

Putative Anticancer Compounds from Plant-Derived Endophytic Fungi: A Review

Isolation, Identification, and Antibacterial Assay of Indigenous Bacterial Isolates from Apis cerana Honeycomb

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