“…Further studies for the regulation of host gene expression by E2 is required for understanding E2-mediated replicative senescence. It is known that PARP-1 is able to modulate cell differentiation and tumorigenesis (Ohashi et al, 1984;Masutani et al, 2001;Smulson et al, 1995). HPV oncoproteins can modulate the ability of primary human keratinocytes to differentiate (Funk et al, 1997;Jones et al, 1999;Sherman and Schlegel, 1996;Sherman et al, 1997).…”