Induction of mu opioid and cannabinoid receptors by probiotics

Rousseaux, Christel; Thuru, Xavier; Gelot, Agathe; Barnich, Nicolas; Neut, Christel; Dubuquoy, Caroline; Ouwehand, Arthur C.; Ardid, Denis; Carcano, Didier; Desreumaux, Pierre

doi:10.1097/00054725-200705001-00035

Cited by 4 publications

(9 citation statements)

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“…hypersensitivity. This was achieved by activating the inflammatory NF-кB pathway to enhance MOR expression (Rousseaux et al, 2007). Fecal microbiota transplantation (FMT) is currently being investigated as a potential approach to alleviate morphine tolerance in rodents with opioid-induced dysbiosis (Muchhala et al, 2023).…”

Section: Discussionmentioning

confidence: 99%

Genetically supported causality between gut microbiota, immune cells and morphine tolerance: a two-sample Mendelian randomization study

Han,

Gao,

Wang

et al. 2024

Front. Microbiol.

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BackgroundPrevious researches have suggested a significant connection between the gut microbiota/immune cells and morphine tolerance (MT), but there is still uncertainty regarding their causal relationship. Hence, our objective is to inverstigate this causal association and reveal the impact of gut microbiota/immune cells on the risk of developing MT using a two-sample Mendelian randomization (MR) study.MethodsWe conducted a comprehensive analysis using genome-wide association study (GWAS) summary statistics for gut microbiota, immune cells, and MT. The main approach employed was the inverse variance-weighted (IVW) method in MR. To assess horizontal pleiotropy and remove outlier single-nucleotide polymorphisms (SNPs), we utilized the Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO) technique as well as MR-Egger regression. Heterogeneity detection was performed using Cochran’s Q-test. Additionally, leave-one-out analysis was carried out to determine if any single SNP drove the causal association signals. Finally, we conducted a reverse MR to evaluate the potential of reverse causation.ResultsWe discovered that 6 gut microbial taxa and 16 immune cells were causally related to MT (p < 0.05). Among them, 2 bacterial features and 9 immunophenotypes retained a strong causal relationship with lower risk of MT: genus. Lachnospiraceae NK4A136group (OR: 0.962, 95% CI: 0.940–0.987, p = 0.030), genus. RuminococcaceaeUCG011 (OR: 0.960, 95% CI: 0.946–0.976, p = 0.003), BAFF-R on B cell (OR: 0.972, 95% CI: 0.947–0.998, p = 0.013). Furthermore, 4 bacterial features and 7 immunophenotypes were identified to be significantly associated with MT risk: genus. Flavonifractor (OR: 1.044, 95% CI: 1.017–1.069, p = 0.029), genus. Prevotella9 (OR: 1.054, 95% CI: 1.020–1.090, p = 0.037), B cell % CD3-lymphocyte (OR: 1.976, 95% CI: 1.027–1.129, p = 0.026). The Cochrane’s Q test revealed no heterogeneity (p > 0.05). Furthermore, the MR-Egger and MR-PRESSO analyses reveal no instances of horizontal pleiotropy (p > 0.05). Besides, leave-one-out analysis confirmed the robustness of MR results. After adding BMI to the multivariate MR analysis, the gut microbial taxa and immune cells exposure-outcome effect were attenuated.ConclusionOur research confirm the potential link between gut microbiota and immune cells with MT, shedding light on the mechanism by which gut microbiota and immune cells may contribute to MT. These findings lay the groundwork for future investigations into targeted prevention strategies.

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Section: Discussionmentioning

confidence: 99%

Genetically supported causality between gut microbiota, immune cells and morphine tolerance: a two-sample Mendelian randomization study

Han,

Gao,

Wang

et al. 2024

Front. Microbiol.

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“…For instance, administering antibiotics effectively reduced visceral pain in murine models induced by intraperitoneal acetic acid or capsaicin applied to the colon (Aguilera et al, 2015). Conversely, the application of certain Lactobacillus strains augmented the expression of cannabinoid receptors in the intestinal epithelial cells, conveying analgesic functions within the digestive tract in a mouse model (Rousseaux et al, 2007). Likewise, clinical trials have successfully demonstrated the effectiveness of certain probiotics in relieving functional abdominal pain; these probiotics include Lactobacillus rhamnosus GG, a mixture of Bifidobacterium infantis M-63, breve M-16V, and longum BB536, as well as Lactobacillus acidophilus NCFM (Rousseaux et al, 2007;Horvath et al, 2011;Ringel-Kulka et al, 2014).…”

Section: Gut Microbiotamentioning

confidence: 99%

“…Conversely, the application of certain Lactobacillus strains augmented the expression of cannabinoid receptors in the intestinal epithelial cells, conveying analgesic functions within the digestive tract in a mouse model (Rousseaux et al, 2007). Likewise, clinical trials have successfully demonstrated the effectiveness of certain probiotics in relieving functional abdominal pain; these probiotics include Lactobacillus rhamnosus GG, a mixture of Bifidobacterium infantis M-63, breve M-16V, and longum BB536, as well as Lactobacillus acidophilus NCFM (Rousseaux et al, 2007;Horvath et al, 2011;Ringel-Kulka et al, 2014). Notably, fecal microbiota transplantation was employed to establish that visceral allergy in rats could be caused by engraftment with gut microbiota obtained from IBS patients afflicted by visceral allergy (Saulnier et al, 2011).…”

Section: Gut Microbiotamentioning

confidence: 99%

Research hotspots and trend analysis of abdominal pain in inflammatory bowel disease: a bibliometric and visualized analysis

Peng,

Xia,

Wang

et al. 2023

Front. Pharmacol.

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Aims: The study aimed to provide a bibliometric and visual analysis of research on abdominal pain in inflammatory bowel disease and discuss the current status, research hotspots, and future developments.Methods: We used the Web of Science Core Collection to comprehensively search the literature on abdominal pain-related research in IBD published between 2003 and 2022. The bibliometric and visual analysis was performed through CiteSpace, VOSviewer software, R language, and the bibliometric online analysis platform, including authors, institutions, countries, journals, references, and keywords in the literature.Results: A total of 3,503 relevant articles are included, indicating that the number of articles in this field has increased in recent years. The United States leads the way with a dominant position in terms of article output, followed by China and JAPAN. United States (967 articles), University of Calgary (98 articles), and World Journal of Gastroenterology (127 articles) are the top publishing countries, institutions, and journals, respectively; keyword analysis shows that gut microbiota, depression, stress, visceral hypersensitivity, and multidisciplinary approach are the hot spots and trends in this research area.Conclusion: Abdominal pain-related studies in IBD have received increasing attention in the past two decades. This study provides the first bibliometric analysis of papers in this research area using visualization software and data information mining. It provides insights into this field’s current status, hot spots, and trends. However, many outstanding issues in this research area still need further exploration to provide a theoretical basis for its clinical application.

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“…The intestinal microbiota, therefore, determines the physiology of adipose tissue through the regulatory loops of the LPS-eCB system and could have critical functions in adipose tissue plasticity during obesity. The microbiota also modulates intestinal eCB tone; as an example, Rousseaux et al (85) showed that the expression of intestinal epithelial CB 2 receptor increases when mice or rats are orally administered the bacterium Lactobacillus acidophilus. More recently it was found that the bacterium Akkermansia muciniphila is a prominent regulator of the gut eCB tone, gut permeability, and secretion of gut peptides (86); see also (78) for a comprehensive review.…”

Section: Endocannabinoids and Intestinal Microbiota Regulate Gut Home...mentioning

confidence: 99%

Gut microbiota and oleoylethanolamide in the regulation of intestinal homeostasis

et al. 2023

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A vast literature strongly suggests that the endocannabinoid (eCB) system and related bioactive lipids (the paracannabinoid system) contribute to numerous physiological processes and are involved in pathological conditions such as obesity, type 2 diabetes, and intestinal inflammation. The gut paracannabinoid system exerts a prominent role in gut physiology as it affects motility, permeability, and inflammatory responses. Another important player in the regulation of host metabolism is the intestinal microbiota, as microorganisms are indispensable to protect the intestine against exogenous pathogens and potentially harmful resident microorganisms. In turn, the composition of the microbiota is regulated by intestinal immune responses. The intestinal microbial community plays a fundamental role in the development of the innate immune system and is essential in shaping adaptive immunity. The active interplay between microbiota and paracannabinoids is beginning to appear as potent regulatory system of the gastrointestinal homeostasis. In this context, oleoylethanolamide (OEA), a key component of the physiological systems involved in the regulation of dietary fat consumption, energy homeostasis, intestinal motility, and a key factor in modulating eating behavior, is a less studied lipid mediator. In the small intestine namely duodenum and jejunum, levels of OEA change according to the nutrient status as they decrease during food deprivation and increase upon refeeding. Recently, we and others showed that OEA treatment in rodents protects against inflammatory events and changes the intestinal microbiota composition. In this review, we briefly define the role of OEA and of the gut microbiota in intestinal homeostasis and recapitulate recent findings suggesting an interplay between OEA and the intestinal microorganisms.

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Induction of mu opioid and cannabinoid receptors by probiotics

Cited by 4 publications

References 0 publications

Genetically supported causality between gut microbiota, immune cells and morphine tolerance: a two-sample Mendelian randomization study

Genetically supported causality between gut microbiota, immune cells and morphine tolerance: a two-sample Mendelian randomization study

Research hotspots and trend analysis of abdominal pain in inflammatory bowel disease: a bibliometric and visualized analysis

Gut microbiota and oleoylethanolamide in the regulation of intestinal homeostasis

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