Induction of Mn-superoxide dismutase by Tumor Necrosis Factor, Interleukin-1 and Interleukin-6 in human hepatoma cells

Ōno, Minoru; Kohda, Hironobu; Kawaguchi, Tetsu; Ohhira, Masumi; Sekiya, Chihiro; Namiki, Masayoshi; Takeyasu, Akira; Taniguchi, Naoyuki

doi:10.1016/0006-291x(92)91845-h

Cited by 60 publications

(19 citation statements)

References 16 publications

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“…Mn-SOD expression has been shown to be inducible by multiple factors, such as hypoxia, ROS, and inflammatory cytokines, including interleukin-1 and -6 (38,39). It would be interesting in future studies to measure the expression of cytokines, such as interleukin-1 and -6, in primary cancer tissues.…”

Section: Discussionmentioning

confidence: 99%

Mitochondrial Manganese-Superoxide Dismutase Expression in Ovarian Cancer

Rosen

Zhou

et al. 2005

Journal of Biological Chemistry

240

156

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(8,17). Analysis of blood samples from 30 ovarian cancer patients and an equal number of age-matched normal subjects shows significantly increased concentrations of plasma thiobarbituric acid-reactive substances and conjugated dienes in the patient specimens, indicating increased oxidative stress in ovarian cancer (18). However, the same study also shows low levels of SOD, catalase, vitamin C, and vitamin E in the plasma of the patient blood samples, possibly due to their increased utilization in scavenging lipid peroxides as well as their sequestration by tumor cells (18). This is in contrast with the increased serum Mn-SOD observed in another study (17). Decreased Mn-SOD activity and expression have also been reported in certain colorectal carcinomas and pancreatic cancer cells (19,20). These apparent conflicting observations are likely because of the different assays and various cell types used in these studies. Thus, it is important to clarify this issue by further examining the expression levels of SOD in a large number of primary human cancer tissues in comparison with normal tissues. Tissue microarray analysis provides an effective tool for such analyses. This new technique was used in the present study to compare the expression of Mn-SOD and Cu,Zn-SOD in primary human ovarian cancer tissues, benign ovarian lesions, and normal tissues. Although the biochemical activity of Mn-SOD in catalyzing the conversion of O 2 Ϫ to H 2 O 2 in the mitochondria has been well characterized, the potential role of Mn-SOD in cancer development remains to be defined. Because the Mn-SOD level seems decreased in certain cancer cells and forced expression of Mn-SOD appears to suppress malignant phenotypes in certain experimental models, this molecule has been con-* This study was supported in part by Grants CA85563, CA100428, and CA109041 (to P. H.) from the NCI, National Institutes of Health, and RSG-04-028-1-CCE (to J. L.) from the American Cancer Society. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. 1 These authors contributed equally to this work.

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Section: Discussionmentioning

confidence: 99%

Mitochondrial Manganese-Superoxide Dismutase Expression in Ovarian Cancer

Rosen

Zhou

et al. 2005

Journal of Biological Chemistry

240

156

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“…IL-6 is also reported to have an ability to induce SOD, but its ability is very low compared with that of IL-1. 42) On the other hand, IL-1 stimulates intracellular IL-6 production, and IL-6 is released from EC 8 h after IL-1 stimulation, 9,10) indicating that IL-6 production may take 16 h after the stimulation by platinum compounds. Therefore, from our results and these reports, we consider that the IL-6 release may be induced by IL-1 stimulation.…”

Section: Secretion Of Gm-csfmentioning

confidence: 99%

Release of Cytokines from Human Umbilical Vein Endothelial Cells Treated with Platinum Compounds in vitro

Shi¹,

Inoue²,

Shinozaki³

et al. 1998

Japanese Journal of Cancer Research

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Endothelial cells (EC) produce cytokines, such as interleukin (IL)-1, IL-6, IL-8 and granulocytemacrophage colony-stimulating factor (GM-CSF). These cytokines have an important role in the proliferation and differentiation of hematopoietic progenitor cells. On the other hand, anticancer agents generally cause hematopoietic disorders. However, little is known about the effects of chemotherapeutic agents on the secretion of cytokines from EC. Therefore, we investigated if treatment with platinum compounds may stimulate EC to secrete cytokines. EC newly isolated from a human umbilical vein were exposed to cisplatin, carboplatin, or TRK-710 for 80 min, then the cells were washed and placed in fresh medium. The levels of cytokines in the fresh medium were measured by the ELISA method, the levels of intracellular hydrogen peroxide (H 2 O 2 ) were measured by flow cytometry, and the rhodamine 123-stained live mitochondria of the EC were observed under a confocal laser microscope. Platinum compounds induced cytokine production in human EC: cisplatin most prominently induced the release of IL-1 and IL-6, and TRK-710 had the greatest ability to induce the release of GM-CSF. Intracellular H 2 O 2 production and IL-8 release were transiently induced immediately after treatment with platinum compounds, leading to IL-1 release when H 2 O 2 production was eliminated. These results may provide new insights into the hematological toxicity induced by anticancer agents and the role of IL-1 and IL-6 secreted from EC in this toxicity.

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“…In line with this, MnSOD is induced by multiple stress conditions both in vitro and in vivo. MnSOD induction occurs after exposure to cytokines (TNF-α , IFN-γ, IL-1, IL-6) (Ono et al, 1992), cigarette smoke (Gilks et al, 1998), chronic hypoxia (Clerch et al, 1998), asbestos fibers (Janssen et al, 1992), radiation (Guo et al, 2003) and modulators of intracellular redox and/or thiol state (Das et al, 1995). Most of these parameters are age dependent factors and adding smoking as a cofactor in our model, the effect of SOD polymorphism on ox-LDL-C levels remained statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Age-dependent dichotomous effect of superoxide dismutase Ala16Val polymorphism on oxidized LDL levels

et al. 2008

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We investigated the association between superoxide dismutase (SOD) Ala16Val polymorphism and the levels of oxidized LDL lipoprotein-C (ox-LDL-C) in two age-different Greek cohorts. Four hundred fifteen middle-aged (n = 147 females: 43.2 ± 13 years, n = 268 males: 43.3 ± 14 years) Caucasian Greek subjects consisted the middle aged cohort. One hundred seventy five elderly (n = 88 females: 79.9 ± 4 years; n = 87 males: 80.6 ± 4 years) were selected from the elderly cohort. Genotype data were obtained for all of them. Multiple linear regression analysis, stratified by gender and adjusted for age, smoking habits and body mass index as covariates, showed higher ox-LDL-C levels for

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Induction of Mn-superoxide dismutase by Tumor Necrosis Factor, Interleukin-1 and Interleukin-6 in human hepatoma cells

Cited by 60 publications

References 16 publications

Mitochondrial Manganese-Superoxide Dismutase Expression in Ovarian Cancer

Mitochondrial Manganese-Superoxide Dismutase Expression in Ovarian Cancer

Release of Cytokines from Human Umbilical Vein Endothelial Cells Treated with Platinum Compounds in vitro

Age-dependent dichotomous effect of superoxide dismutase Ala16Val polymorphism on oxidized LDL levels

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