1982
DOI: 10.1016/0006-291x(82)91968-4
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Induction of mitosis in primary cultures of adult rat hepatocytes under serum-free conditions

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Cited by 82 publications
(41 citation statements)
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“…It was reported that HSS alone had little effect on the DNA synthesis of the resting hepatocytes as in the primary culture hepatocytes, but in contrast, if combined with EGF, it could amplify the growth response of the cells to EGF both in vitro [20,21] and in vivo [22]. The EGF participation in the regulation of liver proliferation was demonstrated in the down-regulation of EGF receptor following partial hepatectomy [23].…”
Section: Discusionmentioning
confidence: 99%
“…It was reported that HSS alone had little effect on the DNA synthesis of the resting hepatocytes as in the primary culture hepatocytes, but in contrast, if combined with EGF, it could amplify the growth response of the cells to EGF both in vitro [20,21] and in vivo [22]. The EGF participation in the regulation of liver proliferation was demonstrated in the down-regulation of EGF receptor following partial hepatectomy [23].…”
Section: Discusionmentioning
confidence: 99%
“…Recently, several groups including ours found that adult rat hepatocytes in primary culture, which retain many of their in vivo liver functions, can proliferate when cultured at low density in medium containing insulin and epidermal growth factor (EGF) (1)(2)(3)(4)(5)(6). Thus, primary cultures of adult rat hepatocytes are a suitable in vitro system for use in studies on the humoral factor for hepatocyte growth.…”
mentioning
confidence: 99%
“…Mature rat hepatocytes in primary culture proliferate at low cell density in the presence of insulin and epidermal growth factor (EGF) (1)(2)(3)(4)(5). A density-dependent mechanism regulates entry of the cells into the cell cycle (1,3,4,6).…”
mentioning
confidence: 99%