Induction of microsomal drug-metabolizing enzymes caused by hexobarbital

Lindner, E; Beyhl, Friedrich E.

doi:10.1007/bf01944693

Cited by 8 publications

(2 citation statements)

References 9 publications

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“…and the effects on this enzyme of injected anthracene. NADPH-tetrazolium reductase (or 'diaphorase') has been shown to be linked with the electron transport system of the cytochrome P450-linked mixed function oxygenases in mammals (Hardonk & Koudstaal 1976;Lindner & Beyhl 1978) where it is believed to be a reduced flavoprotein component acting as the neotetrazolium reductase (Koudstaal & Hardonk 1969). Microcrystalline suspensions of anthracene in sterile saline (100 pi) containing 1% acetone were injected into the mussels via the posterior adductor muscle sinus at four dose levels (10, 25, 50 and 100 pg anthracene per mussel).…”

Section: S Ome Effects Of Petroleum Hydrocarbons On Bivalve Molluscsmentioning

confidence: 99%

Measurement of the responses of individuals to environmental stress and pollution: studies with bivalve molluscs

Bayne

Moore

Widdows

et al. 1979

Phil. Trans. R. Soc. Lond. B

194

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Certain physiological differences between individuals in different populations of the mussel, Mytilus edulis, are described. In particular, the scope for growth differs in space and time and may be used to assess the animals' physiological condition. When the required measurements are made in the field, the rates of growth predicted from the physiological data agree well with observed rates of growth. An alternative approach utilizes mussels transplanted to various waters, with indices of condition then measured in then measured in the laboratory under standard conditions; an example of this approach is illustrated. Laboratory experiments are used to equate various levels of physiological condition with fecundity, in an attempt to equate physiological effects on the individual with likely population damage. A cytochemical index of stress is described, based on the latency of lysosomal enzymes; spatial variability in this index, and its relation with the scope for growth, are discussed. Finally, the results of some experiments on the effects of petroleum hydrocarbons on mussels are described and the presence of inducible activity of NADPH-dependent tetrazolium reductase in the blood cells is demonstrated. Certain considerations that apply in adopting similar measurements of biological effects of pollution in environmental monitoring programmes are discussed.

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Section: S Ome Effects Of Petroleum Hydrocarbons On Bivalve Molluscsmentioning

confidence: 99%

Measurement of the responses of individuals to environmental stress and pollution: studies with bivalve molluscs

Bayne

Moore

Widdows

et al. 1979

Phil. Trans. R. Soc. Lond. B

194

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“…edulis has been indicated from cytochemical investigations of the distribution of NADPH neotetrazolium reductase (Bayne et al, 1979~ Moore, 1979Widdows et al, 1980a), which appears to represent the oxidation of NADPH by the microsomal respiratory chain terminating in the mixed function oxygenase (Koudstaal & Hardonk, 1969, 1972~ Richards, 19731 Hardonk & Koudstaal, 1976Chayen, 1978;Lindner & Beyhl, 1978). Previous results show that NADPH neotetrazolium reductase is particularly active in the blood cells (haemocytes) of hz/.…”

Section: Introductionmentioning

confidence: 99%

Mixed function oxygenases and xenobiotic detoxication/toxication systems in bivalve molluscs

Moore

Livingstone

Донкин

et al. 1980

Helgolander Meeresunters

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Components of a xenobiotic detoxication/toxication system involving mixed function oxygenases are present in h4ytilus edulis. Our paper critically reviews the recent literature on this topic which reported the apparent absence of such a system in bivalve molluscs and attempts to reconcile this viewpoint with our own findings on NADPH neotetrazolium reductase, glucose-6-phosphate dehydrogenase, aldrin epoxidation and other reports of the presence of mixed function oxygenases. New experimental data are presented which indicate that some elements of the detoxicatio~/toxication system in M. edulis can be induced by aromatic hydrocarbons derived from crude oil. This includes a brief review of the results of long-term experiments in which mussels were exposed to low concentrations of the water accommodated fraction of North Sea crude oil (7.7-68/~g 1-1} in which general stress responses such as reduced physiological scope for growth, cytotoxic damage to lysosomal integrity and cellular damage are considered as characteristics of the general stress syndrome induced by the toxic action of the xenobiotics. In addition, induction in the blood cells of microsomal NADPH neotetrazolium reductase {associated with mixed function oxygenases) and the NADPH generating enzyme glucose-6-phosphate dehydrogenase are considered to be specific biological responses to the presence of aromatic hydrocarbons. The consequences of this detoxication/toxication system for Mytilus edulls are discussed in terms of the formation of toxic electrophilic intermediate metabolites which are highly reactive and can combine with DNA, RNA and proteins with subsequent damage to these cellular constituents.

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Diphasic action of 2,2-diphenylpropionic acid N,N-diethylaminoethyl ester hydrochloride on hepatic drug metabolism in the mouse

Beyhl¹,

Lindner²,

Sinharay³

1982

Experientia

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Induction of microsomal drug-metabolizing enzymes caused by hexobarbital

Cited by 8 publications

References 9 publications

Measurement of the responses of individuals to environmental stress and pollution: studies with bivalve molluscs

Measurement of the responses of individuals to environmental stress and pollution: studies with bivalve molluscs

Mixed function oxygenases and xenobiotic detoxication/toxication systems in bivalve molluscs

Diphasic action of 2,2-diphenylpropionic acid N,N-diethylaminoethyl ester hydrochloride on hepatic drug metabolism in the mouse

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