Induction of matrix metalloproteinase, cytokines and chemokines in rat cortical astrocytes exposed to plasminogen activators

Lee, Sun-Ryung; Guo, Shuzhen; Scannevin, Robert H.; Magliaro, Brian C.; Rhodes, Kenneth J.; Wang, Xiaoying; Lo, Eng H.

doi:10.1016/j.neulet.2007.01.017

Cited by 59 publications

(35 citation statements)

References 19 publications

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“…35 CCL3 induction might be cell specific since rtPA had no effect on CCL3 production in cultured astrocytes. 36 CCL3 binds to the CC-chemokine receptors CCR1 and CCR5, which are expressed by all cells within the central nervous system, including microglia. 37 It was suggested that CCR5 activation on microglia might protect again microglial neurotoxicity.…”

Section: Discussionmentioning

confidence: 99%

Recombinant Tissue Plasminogen Activator Enhances Microglial Cell Recruitment after Stroke in Mice

Lenglet

Montecucco

Coutts

et al. 2014

J Cereb Blood Flow Metab

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The effect of recombinant human tissue plasminogen activator (rtPA) on neuroinflammation after stroke remains largely unknown. Here, we tested the effect of rtPA on expression of cellular adhesion molecules, chemokines, and cytokines, and compared those with levels of inflammatory cell recruitment, brain injury, and mortality over 3 days after transient middle cerebral artery occlusion (MCAO) in mice. Mortality was dramatically increased after rtPA treatment compared with saline treatment during the first day of reperfusion. Among the animals that survived, rtPA significantly increased CCL3 expression, microglia recruitment, and cerebral infarction 6 hours after MCAO. In contrast, the extent of neutrophils and macrophages infiltration in the brain was similar in both saline-and rtPA-treated animals. Recombinant human tissue plasminogen activator induced Il1b and Tnf expression, 6 and 72 hours after MCAO, respectively, and dramatically reduced interleukin 6 (IL-6) level 24 hours after reperfusion. A dose response study confirmed the effect of rtPA on CCL3 and Il1b expressions. The effect was similar at the doses of 1 and 10 mg/kg. In conclusion, we report for the first time that rtPA amplified microglia recruitment early after stroke in association with a rapid CCL3 production. This early response may take part in the higher susceptibility of rtPA-treated animals to reperfusion injury.

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Section: Discussionmentioning

confidence: 99%

Recombinant Tissue Plasminogen Activator Enhances Microglial Cell Recruitment after Stroke in Mice

Lenglet

Montecucco

Coutts

et al. 2014

J Cereb Blood Flow Metab

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“…Both tPA and urokinase can activate MMP-9 in vitro. 48 It has been shown that MMP-9 baseline levels predict the appearance of ICH after tPA treatment, 49 and that tPA can activate MMP-9. 50 Simvastatin reduces tPA-induced upregulation of MMP-9 expression in rat cortical astrocytes in vitro.…”

Section: Discussionmentioning

confidence: 99%

Prior Statin Use, Intracranial Hemorrhage, and Outcome After Intra-Arterial Thrombolysis for Acute Ischemic Stroke

Meier

Nedeltchev

Brekenfeld

et al. 2009

Stroke

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Background and Purpose-There are only limited data on whether prior statin use and/or cholesterol levels are associated with intracranial hemorrhage (ICH) and outcome after intra-arterial thrombolysis. The purpose of this study was to evaluate the association of statin pretreatment and cholesterol levels with the overall frequency of ICH, the frequency of symptomatic ICH, and clinical outcome at 3 months. Methods-We analyzed 311 consecutive patients (mean age, 63 years; 43% women) who received intra-arterial thrombolysis. Results-Statin pretreatment was present in 18%.

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“…bFGF can significantly induce uPA expression [21]. uPA can rapidly upregulate MMP-9 in a dose-dependent manner [22]. uPAmediated direct activation of MMP-9 may promote glioblastomas cell invasion [23].…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Tumor-Related Molecular Expression in Gastric Carcinoma

Zhao

Wang

et al. 2009

Pathol. Oncol. Res.

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In order to identify reliable molecular markers for prognostic prediction in gastric carcinoma, we evaluated the expression of six molecular markers, namely bFGF, IGF-2, HGF, MMP-9, integrin beta3 and uPA in gastric cancer. There was a significant correlation between the expression of these markers and the depth of tumor invasion, vessel invasion, lymph node and distant metastasis, TNM stage and microvessel density. The average survival time and 5-year survival rate of patients with positive expression of molecular markers was higher than those with negative expression. Multivariate analysis showed that abnormal expression of bFGF, MMP-9 and uPA, as well as depth of invasion, lymph node and distant metastasis and TNM stage were independently related to poor prognosis of gastric cancer. MMP-9, bFGF and uPA are potential candidates for development as clinically applicable molecular prognostic markers for gastric carcinoma, and may be effective therapeutic targets for the disease in the future.

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Induction of matrix metalloproteinase, cytokines and chemokines in rat cortical astrocytes exposed to plasminogen activators

Cited by 59 publications

References 19 publications

Recombinant Tissue Plasminogen Activator Enhances Microglial Cell Recruitment after Stroke in Mice

Recombinant Tissue Plasminogen Activator Enhances Microglial Cell Recruitment after Stroke in Mice

Prior Statin Use, Intracranial Hemorrhage, and Outcome After Intra-Arterial Thrombolysis for Acute Ischemic Stroke

Prognostic Value of Tumor-Related Molecular Expression in Gastric Carcinoma

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