Induction of macrophage production and proliferation by a purified colony stimulating factor

Stanley, E. Richard; Chen, D M; Lin, Huawen

doi:10.1038/274168a0

Cited by 205 publications

(100 citation statements)

References 18 publications

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“…In addition, significant differences in the size and density distributions of target cells have been observed between crude CSF preparations from different sources (18)(19)(20)(21). These findings have indicated the existence of at least two types of CSF-one that primarily stimulates macrophage production (8,22) and another (or others) that primarily stimulates granulocyte production. In this paper we describe the development of a CSF radioimmunoassay (RIA) and its use, in conjunction with the bioassay, in delineating a distinct subclass of CSF that stimulates macrophage production.…”

mentioning

confidence: 66%

Colony-stimulating factor (CSF) radioimmunoassay: detection of a CSF subclass stimulating macrophage production.

Stanley

1979

Proc. Natl. Acad. Sci. U.S.A.

149

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Colony-stimulating factors (CSFs) stimulate the differentiation of immature precursor cells to mature granulocytes and macrophages. Purified 1251-labeled murine L cell CSF has been used to develop a radioimmunoassay (RIA) that detects a subclass of CSFs that stimulates macrophage production. Murine CSF preparations that contain this subclass of CSF compete for all of the CSF binding sites on anti-L cell CSF antibody. With the exception of mouse serum, which can contain inhibitors of the bioassay, there is complete correspondence between activities determined by RIA and those determined by bioassay. The RIA is slightly more sensitive than the biosassay, detecting approximately 0.3 fmol of purified L cell CSF. It can also detect this subclass of CSF in chickens, rats, and humans. In the mouse, the subclass is distinguished from other CSFs by a murine cell bioassay dose-response curve in which 90% of the response occurs over a 10-fold (rather than a 100-fold) increase in concentration, by stimulating the formation of colonies containing a high proportion of mononuclear (rather than granulocytic) cells, and by certain physical characteristics.

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mentioning

confidence: 66%

Colony-stimulating factor (CSF) radioimmunoassay: detection of a CSF subclass stimulating macrophage production.

Stanley

1979

Proc. Natl. Acad. Sci. U.S.A.

149

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“…[78][79][80] It elicits its effect through binding with the CSF-1 receptor (CSF-1R); a high-affinity receptor tyrosine kinase encoded by the c-fms proto-oncogene. 81 CSF-1 is produced by a range of cell types and acts both locally and humorally in an autocrine and paracrine manner.…”

Section: Csf-1 As a Developmental Mediatormentioning

confidence: 99%

Macrophages and CSF-1

Jones¹,

Ricardo

2013

Organogenesis

123

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“…T he glycoprotein, colony-stimulating factor-1 (CSF-1), also known as macrophage-CSF (M-CSF), was the first of the CSFs to be purified (Stanley and Heard 1977) and was shown to stimulate the formation of colonies of macrophages (Stanley et al 1978). This led to the identification (Guilbert and Stanley 1980) and purification (Yeung et al 1987) of the CSF-1 receptor (CSF-1R) and the demonstration that it possessed intrinsic tyrosine kinase activity (Yeung et al 1987).…”

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confidence: 99%

CSF-1 Receptor Signaling in Myeloid Cells

Stanley

Chiţu

2014

Cold Spring Harbor Perspectives in Biology

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600

521

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The CSF-1 receptor (CSF-1R) is activated by the homodimeric growth factors colony-stimulating factor-1 (CSF-1) and interleukin-34 (IL-34). It plays important roles in development and in innate immunity by regulating the development of most tissue macrophages and osteoclasts, of Langerhans cells of the skin, of Paneth cells of the small intestine, and of brain microglia. It also regulates the differentiation of neural progenitor cells and controls functions of oocytes and trophoblastic cells in the female reproductive tract. Owing to this broad tissue expression pattern, it plays a central role in neoplastic, inflammatory, and neurological diseases. In this review we summarize the evolution, structure, and regulation of expression of the CSF-1R gene. We discuss the structures of CSF-1, IL-34, and the CSF-1R and the mechanism of ligand binding to and activation of the receptor. We further describe the pathways regulating macrophage survival, proliferation, differentiation, and chemotaxis downstream from the CSF-1R.

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Induction of macrophage production and proliferation by a purified colony stimulating factor

Cited by 205 publications

References 18 publications

Colony-stimulating factor (CSF) radioimmunoassay: detection of a CSF subclass stimulating macrophage production.

Colony-stimulating factor (CSF) radioimmunoassay: detection of a CSF subclass stimulating macrophage production.

Macrophages and CSF-1

CSF-1 Receptor Signaling in Myeloid Cells

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