1978
DOI: 10.1038/274168a0
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Induction of macrophage production and proliferation by a purified colony stimulating factor

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1979
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Cited by 205 publications
(100 citation statements)
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“…In addition, significant differences in the size and density distributions of target cells have been observed between crude CSF preparations from different sources (18)(19)(20)(21). These findings have indicated the existence of at least two types of CSF-one that primarily stimulates macrophage production (8,22) and another (or others) that primarily stimulates granulocyte production. In this paper we describe the development of a CSF radioimmunoassay (RIA) and its use, in conjunction with the bioassay, in delineating a distinct subclass of CSF that stimulates macrophage production.…”
mentioning
confidence: 66%
“…In addition, significant differences in the size and density distributions of target cells have been observed between crude CSF preparations from different sources (18)(19)(20)(21). These findings have indicated the existence of at least two types of CSF-one that primarily stimulates macrophage production (8,22) and another (or others) that primarily stimulates granulocyte production. In this paper we describe the development of a CSF radioimmunoassay (RIA) and its use, in conjunction with the bioassay, in delineating a distinct subclass of CSF that stimulates macrophage production.…”
mentioning
confidence: 66%
“…[78][79][80] It elicits its effect through binding with the CSF-1 receptor (CSF-1R); a high-affinity receptor tyrosine kinase encoded by the c-fms proto-oncogene. 81 CSF-1 is produced by a range of cell types and acts both locally and humorally in an autocrine and paracrine manner.…”
Section: Csf-1 As a Developmental Mediatormentioning
confidence: 99%
“…T he glycoprotein, colony-stimulating factor-1 (CSF-1), also known as macrophage-CSF (M-CSF), was the first of the CSFs to be purified (Stanley and Heard 1977) and was shown to stimulate the formation of colonies of macrophages (Stanley et al 1978). This led to the identification (Guilbert and Stanley 1980) and purification (Yeung et al 1987) of the CSF-1 receptor (CSF-1R) and the demonstration that it possessed intrinsic tyrosine kinase activity (Yeung et al 1987).…”
mentioning
confidence: 99%