Induction of Long-Term Memory by Exposure to Novelty Requires Protein Synthesis: Evidence for a Behavioral Tagging

Moncada, Diego; Viola, Haydeé

doi:10.1523/jneurosci.1083-07.2007

Cited by 312 publications

(482 citation statements)

References 39 publications

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“…Recently, several studies have shown that memories can interact with each other by means of synaptic tagging and capture (Almaguer-Melian et al, 2012;Ballarini et al, 2009;Moncada and Viola, 2007;Wang et al, 2010;Myskiw et al, 2013). All these studies show that exposure to novelty can upregulate the synthesis of PRPs, presumably through the release of dopamine, which are then captured at tagged synapses in a cooperative fashion.…”

Section: Discussionmentioning

confidence: 99%

Asymmetrical Synaptic Cooperation between Cortical and Thalamic Inputs to the Amygdale

Fonseca

2013

Neuropsychopharmacol

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Fear conditioning, a form of associative learning is thought to involve the induction of an associative long-term potentiation of cortical and thalamic inputs to the lateral amygdala. Here, we show that stimulation of the thalamic input can reinforce a transient form of plasticity (E-LTP) induced by weak stimulation of the cortical inputs. This synaptic cooperation occurs within a time window of 30 min, suggesting that synaptic integration at amygdala synapses can occur within large time windows. Interestingly, we found that synaptic cooperation is not symmetrical. Reinforcement of a thalamic E-LTP by subsequent cortical stimulation is only observed within a shorter time window. We found that activation of endocannabinoid CB1 receptors is involved in the time restriction of thalamic and cortical synaptic cooperation in an activity-dependent manner. Our results support the hypothesis that synaptic cooperation can underlie associative learning and that synaptic tagging and capture is a general mechanism in synaptic plasticity.

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Section: Discussionmentioning

confidence: 99%

Asymmetrical Synaptic Cooperation between Cortical and Thalamic Inputs to the Amygdale

Fonseca

2013

Neuropsychopharmacol

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“…Methylphenidate stimulates dopamine release in the forebrain by influences on the dopamine vesicular transporter (24)(25)(26)(27), and it was reported long ago to enhance learned behaviors in rats (28,29) and, more recently, in humans (30). The hippocampus detects novelty (31,32) and plays a key role in memory consolidation (2), which relies on novelty (33). Lisman and Grace (34) proposed that the detection of new information by the hippocampus is relayed to the ventral tegmental area (VTA) through the subiculum, accumbens, and ventral pallidum and that the VTA, in turn, projects to the hippocampus through dopaminergic fibers acting on D 1 receptors, where it enhances long-term potentiation (LTP) and learning.…”

Section: Discussionmentioning

confidence: 99%

“…Lisman and Grace (34) proposed that the detection of new information by the hippocampus is relayed to the ventral tegmental area (VTA) through the subiculum, accumbens, and ventral pallidum and that the VTA, in turn, projects to the hippocampus through dopaminergic fibers acting on D 1 receptors, where it enhances long-term potentiation (LTP) and learning. The hippocampal-VTA loop has, in fact, been found to be important for novelty detection (32), for the generation and maintenance of hippocampal LTP (35), and for memory consolidation (34,36). The VTA plays a key role in psychomotor stimulation, particularly in the generation of drug addiction, mediated by local glutamate receptors and dopamine projections to the accumbens and elsewhere (37)(38)(39)(40).…”

Section: Discussionmentioning

confidence: 99%

Age-dependent and age-independent human memory persistence is enhanced by delayed posttraining methylphenidate administration

Izquierdo

Bevilaqua

Rossato

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

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Healthy human volunteers 16 -82 years of age with at least 10 years of schooling were exposed to two different memory tasks. The first task involved incidental memory. The subjects were asked, as casually as possible: ''Did you watch any movie on TV 2 days ago? And 7 days ago? If so, do you remember the title of the movie(s) and the name of the first two actors (actresses)?'' Retention scores (maximum ‫؍‬ 3: title, actor 1, and actor 2) were equally high (overall mean ‫؍‬ 2.6, n ‫؍‬ 61) in all age groups (16 -20, 21-30, 31-40, 41-60, and 61-82 years) for the day 2 scores. Scores for the movie seen 7 days before decreased significantly and progressively in the three older groups in relation to age, which indicates reduced persistence of this type of memory beginning at the age of 41-50 years and becoming more extensive over the years. The other task was a formal memory procedure. Subjects were asked to study a brief text with factual information on the 1954 World Soccer Cup for 10 min. They were then exposed to 10 questions on the text 2 days and, again, 7 days later. Retention scores declined between the two tests, but in this task, the decline of persistence occurred to a similar extent in all age groups, and thus was not dependent on age. Methylphenidate (10 mg p.o.) given 12 hours after acquisition markedly enhanced persistence of the two memory types. This suggests an involvement of dopaminergic processes in persistence in the late posttraining period.aging ͉ human aging ͉ incidental memory ͉ formal memory

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“…Independent, but equivalent behavioral tagging experiments have been recently presented by Moncada and Viola using weak inhibitory avoidance (IA) training as tag and again open field exploration as the event triggering the burst of gene expression (Moncada and Viola, 2007). They found that a weak IA training, which induces short-but not long-term memory (LTM), could be consolidated into LTM by exploration to a novel environment occurring close in time, either before or immediately after, to the training session.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Synapse-specific stabilization of plasticity processes: The synaptic tagging and capture hypothesis revisited 10 years later

Barco

Armentia

Alarcón

2008

Neuroscience & Biobehavioral Reviews

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Synapse-specific stabilization of plasticity processes: The synaptic tagging and capture hypothesis revisited ten years later, Neuroscience and Biobehavioral Reviews (2008Reviews ( ), doi:10.1016Reviews ( /j.neubiorev.2008 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.A c c e p t e d m a n u s c r i p t A c c e p t e d m a n u s c r i p tThe STC hypothesis revisited 2 Abstract A decade ago, the synaptic tagging hypothesis was proposed to explain how newly synthesized plasticity products can be specifically targeted to active synapses. A growing number of studies have validated the seminal findings that gave rise to this model, as well as contributed to unveil and expand the range of mechanisms underlying late-associativity and neuronal computation.Here, we will review what it was learnt during this past decade regarding the cellular and molecular mechanisms underlying synaptic tagging and synaptic capture. The accumulated experimental evidence has widened the theoretical framework set by the synaptic tagging and capture (STC) model and introduced concepts that were originally considered part of alternative models for explaining synapse-specific LTP. As a result, we believe that the STC model, now improved and expanded with these new ideas and concepts, still represents the most compelling hypothesis to explain late-associativity in synapse-specific plasticity processes. We will also discuss the impact of this model in our view of the integrative capability of neurons and associative learning. wordsKeywords: synaptic plasticity; LTP; associative learning; neuronal computation; synaptic tagging; synaptic capture; metaplasticity A c c e p t e d m a n u s c r i p tThe STC hypothesis revisited 3 Contents

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Induction of Long-Term Memory by Exposure to Novelty Requires Protein Synthesis: Evidence for a Behavioral Tagging

Cited by 312 publications

References 39 publications

Asymmetrical Synaptic Cooperation between Cortical and Thalamic Inputs to the Amygdale

Asymmetrical Synaptic Cooperation between Cortical and Thalamic Inputs to the Amygdale

Age-dependent and age-independent human memory persistence is enhanced by delayed posttraining methylphenidate administration

Synapse-specific stabilization of plasticity processes: The synaptic tagging and capture hypothesis revisited 10 years later

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