Central venous catheter (CVC) placement or peripherally inserted central catheters are a common bedside procedure, which is frequently performed in critically ill neonates. Even though it is a routine procedure in the neonatal critical care unit, it is not uncommon to have complications related to it. Due to the smaller size of the heart in neonates and premature infants, the usual anatomic landmark and distance from the insertion site may not be accurate. As they are commonly performed at bedside, fluoroscopic guidance would not be possible. In this chapter, we describe common cardiac arrhythmias induced by these CVC lines and practical tips to avoid these complications. Proper measurement with correct technique, proper fixation and vigilant watching for migration will reduce the incidence of these complications. It is mandatory that all bed side intensivist should think of central line induced arrhythmias in an ICU settings and should identify and treat it appropriately.