“…Furthermore, spinal cord IL-6 has been implicated in other exaggerated pain states, such as allodynia induced by peripheral nerve injury (Arruda et al, 2000;DeLeo et al, 1996), sciatic inflammatory neuropathy (Chacur et al, 2004;Milligan et al, 2003), and intrathecal fractalkine . IL-6 has been suggested to be involved in nociception at the level of the skin, nerve, dorsal root ganglia (DRG), and spinal cord, and its expression is induced in response to nerve injury in spinal cord, DRG sensory neurons (Arruda et al, 1998;Lee et al, 2004;Murphy et al, 1995), and in peripheral nerves (Ma and Quirion, 2005;Okamoto et al, 2001).…”