Induction of Interleukin-1 Receptor Antagonist (IL-1ra) Following Surgery Is Associated with Major Trauma

Nualláin, E.M. Ó; Puri, Poonam; Mealy, K.; Reen, Denis J.

doi:10.1006/clin.1995.1093

Cited by 25 publications

(13 citation statements)

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“…In pediatric patients, IL-1ra is the earliest cytokine produced even in the absence of an infectious etiology under surgical stress [24][25][26]. In the present study, an exaggerated postoperative IL-1ra response was found and the induction of postoperative IL-1ra in response to surgical stress was more sensitive than IL-6 in neonatal patients.…”

Section: Discussionsupporting

confidence: 52%

Naturally acquired regulatory mechanism of perioperative cytokine response in neonates

et al. 2006

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The inflammatory reaction is known to be controlled in neonates. We clarified the characteristics of cytokine profile in neonatal patients and assess its clinical significance. Serum levels of interleukin (IL)-6 and IL-1 receptor antagonist (ra) were determined in 152 pediatric patients and 33 each of maternal and cord bloods. Supernatant IL-1ra levels of cultured monocytes and granulocytes stimulated with IL-1beta or LPS, and IL-1ra mRNA expression of granulocytes were assayed in 15 each of cord and healthy adult bloods. Although surgical stress in neonates was heavier than that in infants, there was no difference in the occurrence of postoperative morbidity and mortality. In neonates, the perioperative serum level of IL-1ra was significantly raised, and the postoperative IL-6 response was well controlled. The serum concentration of IL-1ra in cord blood was not different from that in maternal blood, whereas, the serum concentration of IL-6 in cord blood was significantly reduced than that in maternal blood. In granulocytes, significantly more IL-1ra was produced from cord than from adult blood. An IL-1ra predominant immune status in neonates may be a naturally acquired adaptation system and play a crucial role in attenuating acute inflammatory reaction in a vulnerable host defense.

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Section: Discussionsupporting

confidence: 52%

Naturally acquired regulatory mechanism of perioperative cytokine response in neonates

et al. 2006

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“…4 Among the major cytokine mediators of stress response, IL-6 is considered to be an early indicator of tissue damage, and recent studies have suggested that IL-6 is a major mediator of the acute phase protein response in humans. [5][6][7] In general, the greater the surgical trauma, the greater the response of serum IL-6 and the greater the peak serum concentration of IL-6. Harmon et al reported that the serum IL-6 levels of patients who underwent laparoscopic colectomy were significantly lower than those of patients who underwent open colectomy, between 3 h and 24 h after the induction of anesthesia.…”

Section: Discussionmentioning

confidence: 99%

Cytokine and Hormonal Responses in Laparoscopic-Assisted Colectomy and Conventional Open Colectomy

et al. 2000

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“…Furthermore, elevated IL-lra levels were seen in plasma after major surgical interventions and may be a sensitive marker for tissue damage. It was supposed that IL-lra released following surgery is produced by tissue macrophages in the operative field in response to necrotic cell components and subsequently enters the peripheral circulation [27,28].…”

Section: Discussionmentioning

confidence: 99%

Different release of cytokines into the cerebrospinal fluid following surgery for intra- and extra-axial brain tumours

et al. 1997

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To elucidate the role of cytokines in brain repair processes and in local inflammation after neurosurgical procedures, cerebrospinal fluid (CSF) samples from 8 patients with intra-axial tumours and 8 patients with extra-axial tumours were analysed for interleukin (IL)-1 beta, IL-1 receptor antagonist (IL-1 ra), IL-6, IL-8, IL-10, and tumour necrosis factor (TNF)-alpha at the beginning and after surgery. Levels of IL-6 and IL-8 increased dramatically in all patients just hours after surgery and fell during subsequent days. IL-1 beta was found only in low amounts in the CSF of both patient groups. Other cytokines demonstrated different courses. In patients with intra-axial tumours IL-1 ra peaked two to four hours after surgery with a subsequent decrease. In patients with extra-axial tumours there was a continuous low-level IL-1 ra release into the CSF without a peak. TNF-alpha was not present in detectable levels in the CSF after surgery for extra-axial tumours but was found to peak two to four hours after surgery for intra-axial tumours. IL-10 was detected in the CSF of both patient groups, but a higher peak was seen after surgery for extra-axial tumours. These results suggest different requirements for the cytokine response and an involvement of different cell types in cytokine release. However, the analysis of the CSF from both patient groups showed no differences in cell counts and populations, with a mild pleocytosis being present in both patient groups after surgery. Therefore, we conclude that after surgery for extra-axial tumours cytokines were predominately produced by non-immune cells stimulated through hypoxia or mechanical irritation. After surgery for intra-axial tumours with a significant brain injury immune cells-activated by necrotic material-seen to be involved in the process of cytokine synthesis. In these cases an additional IL-1ra and TNF-alpha peak was found and these cytokines may be markers for cerebral injury.

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Induction of Interleukin-1 Receptor Antagonist (IL-1ra) Following Surgery Is Associated with Major Trauma

Cited by 25 publications

References 0 publications

Naturally acquired regulatory mechanism of perioperative cytokine response in neonates

Naturally acquired regulatory mechanism of perioperative cytokine response in neonates

Cytokine and Hormonal Responses in Laparoscopic-Assisted Colectomy and Conventional Open Colectomy

Different release of cytokines into the cerebrospinal fluid following surgery for intra- and extra-axial brain tumours

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