Induction of inflammatory mediator release (serotonin and 12-hydroxyeicosatetraenoic acid) from human platelets by Pseudomonas aeruginosa glycolipid

König, Brigitte; Bergmann, Uwe; König, Wolfgang

doi:10.1128/iai.60.8.3150-3155.1992

Cited by 20 publications

(6 citation statements)

References 56 publications

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“…Mast cells, basophils and platelets rapidly release 5‐HT in response to injury, activation of the complement system and release of inflammatory substances, such as immunoglobulin E complexes, and platelet activating factor (PAF), resulting in chemotaxis, phagocytosis and ultimately inflammation (König et al . , Mössner & Lesch , Gordon & Barnes ). 5‐HT directly or indirectly promotes recruitment of mast cells, eosinophils, DCs and neutrophils in acute inflammation (Boehme et al .…”

Section: ‐Ht In Immune Responsementioning

confidence: 99%

The role of serotonin and its receptors in activation of immune responses and inflammation

2014

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Serotonin or 5-hydroxytryptamine (5-HT) is a neurotransmitter and hormone that contributes to the regulation of various physiological functions by its actions in the central nervous system (CNS) and in the respective organ systems. Peripheral 5-HT is predominantly produced by enterochromaffin (EC) cells of the gastrointestinal (GI) tract. These gut-resident cells produce much more 5-HT than all neuronal and other sources combined, establishing EC cells as the main source of this biogenic amine in the human body. Peripheral 5-HT is also a potent immune modulator and affects various immune cells through its receptors and via the recently identified process of serotonylation. Alterations in 5-HT signalling have been described in inflammatory conditions of the gut, such as inflammatory bowel disease. The association between 5-HT and inflammation, however, is not limited to the gut, as changes in 5-HT levels have also been reported in patients with allergic airway inflammation and rheumatoid arthritis. Based on searches for terms such as '5-HT', 'EC cell', 'immune cells' and 'inflammation' in pubmed.gov as well as by utilizing pertinent reviews, the current review aims to provide an update on the role of 5-HT in biological functions with a particular focus on immune activation and inflammation.

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Section: ‐Ht In Immune Responsementioning

confidence: 99%

The role of serotonin and its receptors in activation of immune responses and inflammation

2014

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“…RLs induce the lysis of PMNs while [ 168 , 181 , 182 ], at subtoxic levels, they stimulate both chemotaxis and chemokinesis of PMNs [ 182 ]. RLs also induce histamine release from mast cells [ 183 ], stimulate the production of the inflammatory mediators serotonin and 12-hydroxyeicosatetraenoic acid from human platelets [ 184 ], and also stimulate the release of interleukin (IL)-8, GM-CSF, and IL-6 from nasal epithelial cells[ 185 ].…”

Section: Exoproducts and Secretion Systemsmentioning

confidence: 99%

An Organ System-Based Synopsis ofPseudomonas aeruginosaVirulence

et al. 2021

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Driven in part by its metabolic versatility, high intrinsic antibiotic resistance, and a large repertoire of virulence factors, Pseudomonas aeruginosa is expertly adapted to thrive in a wide variety of environments, and in the process, making it a notorious opportunistic pathogen. Apart from the extensively studied chronic infection in the lungs of people with cystic fibrosis (CF), P. aeruginosa also causes multiple serious infections encompassing essentially all organs of the human body, among others, lung infection in patients with chronic obstructive pulmonary disease, primary ciliary dyskinesia and ventilator-associated pneumonia; bacteremia and sepsis; soft tissue infection in burns, open wounds and postsurgery patients; urinary tract infection; diabetic foot ulcers; chronic suppurative otitis media and otitis externa; and keratitis associated with extended contact lens use. Although well characterized in the context of CF, pathogenic processes mediated by various P. aeruginosa virulence factors in other organ systems remain poorly understood. In this review, we use an organ system-based approach to provide a synopsis of disease mechanisms exerted by P. aeruginosa virulence determinants that contribute to its success as a versatile pathogen.

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“…The presence of 5-HT receptors and the ability of these cells to take up 5-HT suggests that 5-HT influences the activity of the innate immune cells . Following injury or release of inflammatory substances, such as C3a, C5a, and IgE complexes, and PAF, 5-HT is rapidly released from mast cells, basophils, and platelets , and functions in several ways to coordinate the movement and secretion of several cellular cascades involved in carrying out immune responses, including inflammation, chemotaxis, and phagocytosis. 5-HT is chemotactic for eosinophils, dendritic cells, and mast cells, attracting cells to sites of inflammation.…”

Section: The Presence and Role Of 5-ht And Its Targets In The Periphe...mentioning

confidence: 99%

A Dialogue between the Immune System and Brain, Spoken in the Language of Serotonin

Baganz

Blakely

2012

ACS Chem. Neurosci.

272

239

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Neuropsychiatric disorders have long been linked to both immune system activation and alterations in serotonin (5-HT) signaling. In the CNS, the contributions of 5-HT modulate a broad range of targets, most notably, hypothalamic, limbic and cortical circuits linked to the control of mood and mood disorders. In the periphery, many are aware of the production and actions of 5-HT in the gut but are unaware that the molecule and its receptors are also present in the immune system where evidence suggests they contribute to the both innate and adaptive responses. In addition, there is clear evidence that the immune system communicates to the brain via both humoral and neuronal mechanisms, and that CNS 5-HT neurons are a direct or indirect target for these actions. Following a brief primer on the immune system, we describe our current understanding of the synthesis, release, and actions of 5-HT in modulating immune function, including the expression of 5-HT biosynthetic enzymes, receptors, and transporters that are typically studied with respect to the roles in the CNS. We then orient our presentation to recent findings that pro-inflammatory cytokines can modulate CNS 5-HT signaling, leading to a conceptualization that among the many roles of 5-HT in the body is an integrated physiological and behavioral response to inflammatory events and pathogens. From this perspective, altered 5-HT/immune conversations are likely to contribute to risk for neurobehavioral disorders historically linked to compromised 5-HT function or ameliorated by 5-HT targeted medications, including depression and anxiety disorders, obsessive-compulsive disorder (OCD), and autism. Our review raises the question as to whether genetic variation impacting 5-HT signaling genes may contribute to maladaptive behavior as much through perturbed immune system modulation as through altered brain mechanisms. Conversely, targeting the immune system for therapeutic development may provide an important opportunity to treat mental illness.

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Induction of inflammatory mediator release (serotonin and 12-hydroxyeicosatetraenoic acid) from human platelets by Pseudomonas aeruginosa glycolipid

Cited by 20 publications

References 56 publications

The role of serotonin and its receptors in activation of immune responses and inflammation

The role of serotonin and its receptors in activation of immune responses and inflammation

An Organ System-Based Synopsis ofPseudomonas aeruginosaVirulence

A Dialogue between the Immune System and Brain, Spoken in the Language of Serotonin

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