Induction of in vivo DNA adducts by 4 industrial by-products in the rat-lung-cell system

Whong, Wen‐Zong; Stewart, John; Cutler, Deborah; Ong, T.

doi:10.1016/0165-1161(94)90022-1

Cited by 18 publications

(13 citation statements)

References 20 publications

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“…However, these results must be considered preliminary: repairment of adducts, optimal time of exposure, and other parameters need to be studied in order to validate this test under such conditions of exposure. Whong et al (1994) showed that the measurement of DNA adducts was more sensitive than chromosomal aberration tests.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the Bioavailability of PAHs in Rats Exposed to a Polluted Soil by Natural Routes: Induction of EROD Activity and DNA Adducts and PAH Burden in Both Liver and Lung

Fouchécourt¹,

Arnold²,

Berny

et al. 1999

Environmental Research

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Section: Discussionmentioning

confidence: 99%

Assessment of the Bioavailability of PAHs in Rats Exposed to a Polluted Soil by Natural Routes: Induction of EROD Activity and DNA Adducts and PAH Burden in Both Liver and Lung

Fouchécourt¹,

Arnold²,

Berny

et al. 1999

Environmental Research

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“…Three male CD rats (4-6 weeks old) per group were instilled with solvent (negative control), benzo[a]pyrene (B[a]P; positive control), or the test material 3 times every 8-h interval (total 3 doses/chemical) [24,28]. Each dose for test material ranged from 250 to 2,000 mg/kg body weight (bw) and for B[a]P was 10 mg/kg bw.…”

Section: Treatmentmentioning

confidence: 99%

Induction of DNA adducts in vivo in rat lung cells by fume condensates of roofing asphalt

Qian

Ong

Nath

et al. 1998

Teratog. Carcinog. Mutagen.

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“…Dibenzo [a,i]pyrene induced micronucleus formation in bone marrow and spleen polychromatic erythrocytes in rats treated in vivo (Zhong et al, 1995). It induced sister chromatid exchange and micronucleus formation in lung cells cultured in vitro taken from rats dosed by intratracheal instillation (Whong et al, 1994 [a,i]pyrene-3,4-diol in DMSO:tetrahydrofuran (1:10), followed 7 days later by 16 nmol [10 µg] TPA in acetone twice a week for 16 weeks, or 24 weeks for another group treated with 50 nmol only. The incidence of tumours (tumours/mouse) in the dosed groups 17 weeks after treatment was 37 (0.6), 66 (3.03) and 81% (5.0), respectively.…”

Section: Dibenzo[ai]pyrene (I)mentioning

confidence: 99%

“…Dibenz [a,h]anthracene induced sister chromatid exchange and micronucleus formation in lung cells cultured in vitro that were taken from rats treated with dibenz [a,h]anthracene by intratracheal instillation (Whong et al, 1994). Dibenz [a,h]anthracene induced micronucleus formation in bone marrow and spleen polychromatic erythrocytes from rats treated in vivo by intratracheal instillation (Zhong et al, 1995).…”

Section: Cyp1b1mentioning

confidence: 99%

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Integrating Field Analyses with Laboratory Exposures to Assess Ecosystems Health

Hellou¹,

Beach²,

Leonard³

et al. 2012

Polycyclic Aromatic Compounds

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Induction of in vivo DNA adducts by 4 industrial by-products in the rat-lung-cell system

Cited by 18 publications

References 20 publications

Assessment of the Bioavailability of PAHs in Rats Exposed to a Polluted Soil by Natural Routes: Induction of EROD Activity and DNA Adducts and PAH Burden in Both Liver and Lung

Assessment of the Bioavailability of PAHs in Rats Exposed to a Polluted Soil by Natural Routes: Induction of EROD Activity and DNA Adducts and PAH Burden in Both Liver and Lung

Induction of DNA adducts in vivo in rat lung cells by fume condensates of roofing asphalt

Integrating Field Analyses with Laboratory Exposures to Assess Ecosystems Health

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