Induction of immune tolerance toward tumor‐associated‐antigens enables growth of human hepatoma in mice

Gotsman, Israel; Israeli, David; Alper, Ruslana; Rabbani, Elazar; Engelhardt, Dean; Ilan, Yaron

doi:10.1002/ijc.1576

Cited by 18 publications

(12 citation statements)

References 21 publications

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“…In animal models, the presence of numerous maternal cells or soluble antigens in breast milk could induce tolerance to maternal cells (7,8,13), while ingestion of tumor fragments could give the tumor cells a growth advantage (10)(11)(12). These results suggest that breast milk containing maternal leukemic cells, as well as normal cells, might facilitate tolerance to and promote growth of maternal leukemic cells transmitted to the infant during pregnancy.…”

Section: Discussionmentioning

confidence: 93%

“…Breast milk contains a number of maternal antigens and leukocytes. Another report in mice showed that oral feeding of tumor fragments could confer a growth advantage on, and induce immune tolerance to, tumor cells (10)(11)(12). These findings suggest that breast feeding after delivery could promote a survival advantage for and tolerance to maternal BCR-ABL-positive cells, in the event of their transmission to the infant.…”

Section: Introductionmentioning

confidence: 92%

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Detection of BCR-ABL-Positive Cells in the Colostrum of a Pregnant Patient with Chronic Myeloid Leukemia

et al. 2011

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 92%

Detection of BCR-ABL-Positive Cells in the Colostrum of a Pregnant Patient with Chronic Myeloid Leukemia

et al. 2011

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“…Escaping from the surveillance of immune system is the primary cause for malignant growth of HCC cells. 29,30 Several investigations have showed that AFP could be individually synergistic with other growth factors to promote the growth of many tumor cells. 31,32 AFP receptors have been found anchoring on the membrane of various tumor cells.…”

Section: Discussionmentioning

confidence: 99%

Specific Antitumor Immunity Induced by Cross-linking Complex Heat Shock Protein 72 and Alpha-fetoprotein

Wang

Lin

Wang

et al. 2012

Cancer Biotherapy and Radiopharmaceuticals

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Hepatocellular carcinoma (HCC) is one of the most common malignancies over the world. Alpha-fetoprotein (AFP) is an oncofetal protein during HCC development that could generate weaker and less reproducible antitumor protection, and it may serve as a target for immunotherapy. Therefore, it is imperative to enhance its immunogenicity and develop therapeutic vaccines to eliminate AFP-expressing tumors. In this study, by way of glutaraldehyde cross-linking, we constructed a potential therapeutic protein complex vaccine, heat shock protein 72 (HSP72)/AFP. Our results demonstrated that AFP and HSP72 synergistically exhibited significant increases in AFP-specific CD8(+) T cell responses and impressive antitumor effects against AFP-expressing tumors. Priming mice with the reconstructed vaccine, we elicited robust strong protective immunity. Our study suggests that a tumor vaccine by cross-linking tumor antigen and HSP72 is a promising approach for cancer therapy.

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“…Immune responses to these nonmutated self-Ags in tumors are typically weak, primarily due to central and peripheral mechanisms for self tolerance. Nonetheless, the thymus allows for the formation of low-affinity T cells specific to self-Ags (56,57). The purpose of this paper was to use as Ag a nonmutated self protein important in tumorigenesis (in our case, survivin) and identify mechanisms required to elicit strong immunity, particularly a CD4 ϩ helper T cell response.…”

Section: Classes Of Tumor Agsmentioning

confidence: 99%

Dendritic Cell Targeting of Survivin Protein in a Xenogeneic Form Elicits Strong CD4+ T Cell Immunity to Mouse Survivin

Charalambous

Oks

Nchinda

et al. 2006

The Journal of Immunology

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To determine whether strong CD4+ T cell immunity could be induced to a nonmutated self protein that is important for tumorigenesis, we selectively targeted the xenogeneic form of survivin, a survival protein overexpressed in tumors, to maturing dendritic cells in lymphoid tissues. Dendritic cell targeting via the DEC205 receptor in the presence of anti-CD40 and poly(I:C) as maturation stimuli, induced strong human and mouse survivin-specific CD4+ T cell responses, as determined by IFN-γ, TNF-α, and IL-2 production, as well as the development of lytic MHC class II-restricted T cells and memory. Immunity was enhanced further by depletion of CD25+foxp3+ cells before vaccination. anti-DEC205-human survivin was superior in inducing CD4+ T cell responses relative to other approaches involving survivin plasmid DNA or survivin peptides with adjuvants. However, we were unable to induce CD8+ T cell immunity to survivin by two doses of DEC205-targeted survivin or the other strategies. Therefore, significant CD4+ T cell immunity to a self protein that is overexpressed in most human cancers can be induced by DEC205 targeting of the Ag in its xenogeneic form to maturing DCs.

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Induction of immune tolerance toward tumor‐associated‐antigens enables growth of human hepatoma in mice

Cited by 18 publications

References 21 publications

Detection of BCR-ABL-Positive Cells in the Colostrum of a Pregnant Patient with Chronic Myeloid Leukemia

Detection of BCR-ABL-Positive Cells in the Colostrum of a Pregnant Patient with Chronic Myeloid Leukemia

Specific Antitumor Immunity Induced by Cross-linking Complex Heat Shock Protein 72 and Alpha-fetoprotein

Dendritic Cell Targeting of Survivin Protein in a Xenogeneic Form Elicits Strong CD4+ T Cell Immunity to Mouse Survivin

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