INDUCTION OF IgE ANTIBODY PRODUCTION IN MICE WITH DIFFERENT DPT-VACCINE PREPARATIONS

Naito, Seishiro; Takahashi, Masae; Ishida, Susumu; Uchida, Tetsuya

doi:10.7883/yoken1952.48.117

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Development Of Tetanus Vaccines1

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2014

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Cited by 3 publications

(1 citation statement)

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“…A diphtheria-pertussis-tetanus vaccine was shown to induce significant IgE antibody production in mice in addition to the induction of IgG antibody production (20). Therefore, a possible application for surface-linked liposomal antigens in tetanus vaccine development was investigated.…”

Section: Development Of Tetanus Vaccinesmentioning

confidence: 99%

Application of Surface-Linked Liposomal Antigens to the Development of Vaccines That Induce Both Humoral and Cellular Immunity

Uchida

Taneichi

2014

Jpn J Infect Dis

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Section: Development Of Tetanus Vaccinesmentioning

confidence: 99%

Application of Surface-Linked Liposomal Antigens to the Development of Vaccines That Induce Both Humoral and Cellular Immunity

Uchida

Taneichi

2014

Jpn J Infect Dis

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Les réactions allergiques aux vaccinations

Ponvert

Dassonval

Ignatowicz

et al. 1996

Revue Française d'Allergologie et d'Immunologie Clinique

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Immunotoxicity—The Risk is Real

Selgrade

2007

Toxicological Sciences

132

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Several papers published over the last year represent significant progress in closing the gap between rodent immunotoxicity data and human risk and indicate that, at least for the developing immune system, the concern raised by rodent data is justified. The studies reviewed here show that suppression of immune responses in rodents is predictive of suppression of immune responses in humans and that there is a relationship between immune suppression following developmental exposure to the toxicants and enhanced risk of infectious or neoplastic disease in humans. The three cases highlighted here are remarkable in that they all deal with real-world environmental exposures that represent different media -- air (cigarette smoke), water (arsenic), and food (polychlorinated biphenyls [PCBs]) -- and constitute very real risks. Moreover, the arsenic and PCB studies actually demonstrate a quantitative relationship between human exposure and immune suppression. There is evidence that in utero exposure to cigarette smoke and arsenic but not PCBs is associated with increased risk of allergic disease as well. There is clearly potential for designing studies that could address both issues.

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INDUCTION OF IgE ANTIBODY PRODUCTION IN MICE WITH DIFFERENT DPT-VACCINE PREPARATIONS

Cited by 3 publications

References 6 publications

Application of Surface-Linked Liposomal Antigens to the Development of Vaccines That Induce Both Humoral and Cellular Immunity

Application of Surface-Linked Liposomal Antigens to the Development of Vaccines That Induce Both Humoral and Cellular Immunity

Les réactions allergiques aux vaccinations

Immunotoxicity—The Risk is Real

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