Abstract:Hydroxysteroid sulfotransferase (SULT2A) catalyzes the transfer of sulfate from the physiological sulfate donor 3′‐phosphoadenosine‐5′‐phosphosulfate (PAPS) to endogenous and xenobiotic substrates. In human hepatocytes, PAPS synthesis is catalyzed by PAPS synthase 2 (PAPSS2). HepG2 cells were stably transduced with lentivirus expressing either non‐targeting small interfering RNA (siRNA) (siNT‐HepG2) or siRNA directed against PAPS synthase 2 (siPAPSS2‐HepG2). Relative to siNT‐HepG2, siPAPSS2‐HepG2 cells transie… Show more
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