1996
DOI: 10.1016/s0196-9781(96)00214-8
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Induction of histamine release from rat mast cells by bradykinin analogues

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Cited by 10 publications
(2 citation statements)
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“…Furthermore ring-substituted dehydrophenylalanine analogues were used to estimate the influence of the ring-substitution on the activity. From preceding work with bradykinin agonists and antagonists the necessity of estimating the bioactivity at different organs [9,13,14,15,24] had been established. Thus, the smooth muscle organs rat uterus (RUT), guinea pig ileum (GPI) and guinea pig pulmonary artery (PA) were used.…”
Section: Resultsmentioning
confidence: 99%
“…Furthermore ring-substituted dehydrophenylalanine analogues were used to estimate the influence of the ring-substitution on the activity. From preceding work with bradykinin agonists and antagonists the necessity of estimating the bioactivity at different organs [9,13,14,15,24] had been established. Thus, the smooth muscle organs rat uterus (RUT), guinea pig ileum (GPI) and guinea pig pulmonary artery (PA) were used.…”
Section: Resultsmentioning
confidence: 99%
“…Our results also suggest that these mediators can in turn augment the BK effect, as the three antagonists and B2 antagonist together dramatically blocked BK-induced PE, an effect significantly greater than that of B2 antagonist alone. There is evidence that BK is able to induce the release of CGRP, PGs, and histamine in a variety of tissues and cells [ 9 , 10 , 42 ], and these secondary mediators in turn can cause or enhance inflammation [ 7 , 43 45 ]. In comparison, our results show that in 5-HT-stimulated PE, PGs and histamine also play important roles, which is in agreement with our previous studies [ 7 , 46 ], but CGRP is apparently not involved.…”
Section: Discussionmentioning
confidence: 99%