Abstract:The renoprotective mechanisms of hemeoxygenase‐1 (HO‐1) induction remain unclear. We hypothesize that induction of HO‐1 will decrease blood pressure and proteinuria in spontaneously hypertensive rats (SHR) via antioxidant and anti‐inflammatory mechanisms. Male WKY and SHR were injected with the HO‐1 inducer cobalt protoporphrin (CoPP, 1.5 mg/kg s.c. bi‐weekly) for two weeks. CoPP reduced mean arterial pressure (MAP) (133±2 vs. 144±4 mmHg, p<0.05) and proteinuria (24±2 vs. 14±1mg/day, p<0.05) in SHR rats … Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.