Induction of Hair Growth by Insulin-Like Growth Factor-1 in 1,763 MHz Radiofrequency-Irradiated Hair Follicle Cells

Yoon, Sun‐Young; Kim, Kyu‐Tae; Jo, Seong Jin; Cho, A-Ri; Jeon, Soon‐Ik; Choi, Hyung‐Do; Kim, Kyu Han; Park, Gun-Sik; Pack, Jeong‐Ki; Kwon, Oh Sang; Park, Woong-Yang

doi:10.1371/journal.pone.0028474

Cited by 35 publications

(28 citation statements)

References 40 publications

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“…The effects of light therapy on hair growth have been investigated via DPCs . In addition, electromagnetic field resulted in stimulation of DPCs activity . Electrical stimulation also induced hair regrowth by inducing hair follicular proliferation and stimulation of DPCs in vitro .…”

Section: Hair Growth Promoting Effectmentioning

confidence: 95%

Review of Hair Follicle Dermal Papilla cells asin vitroscreening model for hair growth

Madaan

Verma

Singh

et al. 2018

Intern J of Cosmetic Sci

113

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Hair disorders such as hair loss (alopecia) and androgen dependent, excessive hair growth (hirsutism, hypertrichosis) may impact the social and psychological well-being of an individual. Recent advances in understanding the biology of hair have accelerated the research and development of novel therapeutic and cosmetic hair growth agents. Preclinical models aid in dermocosmetic efficacy testing and claim substantiation of hair growth modulators. The in vitro models to investigate hair growth utilize the hair follicle Dermal Papilla cells (DPCs), specialized mesenchymal cells located at the base of hair follicle that play essential roles in hair follicular morphogenesis and postnatal hair growth cycles. In this review, we have compiled and discussed the extensively reported literature citing DPCs as in vitro model to study hair growth promoting and inhibitory effects. A variety of agents such as herbal and natural extracts, growth factors and cytokines, platelet-rich plasma, placental extract, stem cells and conditioned medium, peptides, hormones, lipid-nanocarrier, light, electrical and electromagnetic field stimulation, androgens and their analogs, stress-serum and chemotherapeutic agents etc. have been examined for their hair growth modulating effects in DPCs. Effects on DPCs' activity were determined from untreated (basal) or stress induced levels. Cell proliferation, apoptosis and secretion of growth factors were included as primary end-point markers. Effects on a wide range of biomolecules and mechanistic pathways that play key role in the biology of hair growth were also investigated. This consolidated and comprehensive review summarizes the up-to-date information and understanding regarding DPCs based screening models for hair growth and may be helpful for researchers to select the appropriate assay system and biomarkers. This review highlights the pivotal role of DPCs in the forefront of hair research as screening platforms by providing insights into mechanistic action at cellular level, which may further direct the development of novel hair growth modulators.

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Section: Hair Growth Promoting Effectmentioning

confidence: 95%

Review of Hair Follicle Dermal Papilla cells asin vitroscreening model for hair growth

Madaan

Verma

Singh

et al. 2018

Intern J of Cosmetic Sci

113

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“…The onset of catagen is heralded by a reduction in the number of cells, achieved in part via an increase in programmed cell death (apoptosis) within the matrix (Driskell et al, 2011;Lindner et al, 1997;Lippens et al, 2009;, Tobin et al, 2003) mediated by brain-derived neurotrophic factor and neurotrophin-4 (Botchkarev et al, 1999), and transforming growth factor-beta signaling (Botchkarev et al, , 2003Foitzik et al, 2000). This apoptotic effect is counteracted by prosurvival Wnt signals (Choi et al, 2013;Kandyba and Kobielak, 2014;Myung et al, 2013), which activate fibroblast growth factor and insulin-like growth factor signaling to enhance cell proliferation (Enshell-Seijffers et al, 2010;Katsuoka et al, 1987;Yoon et al, 2011). The onset of catagen is also retarded by glial-derived neurotrophic factor and neurturin , possibly through their effects on increasing the survival of fibroblast growth factor 5-expressing cells in the outer root sheath (Pena et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Activating Hair Follicle Stem Cells via R-spondin2 to Stimulate Hair Growth

Smith

Liu

et al. 2016

Journal of Investigative Dermatology

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Wnt signaling is required for the development of the hair follicle, and for inciting the growth (anagen) phase of the hair cycle. Most strategies to enhance Wnt signaling for hair growth create a state of constitutive Wnt activation, which leads to neoplastic transformation of the epithelial hair matrix. Using Axin2(LacZ/+) and Axin2(Cre/+)R26R(mTmG/+) reporter mice and RNA analyses, we show that Wnt signaling is elevated during anagen, is reduced at the onset of catagen, and can be reamplified in the skin and surrounding hair follicles via intradermal injection of recombinant R-spondin2 protein. Using Lgr5(LacZ/+) reporter mice, we demonstrate that this amplified Wnt environment leads to activation of leucine-rich repeat-containing G-protein coupled receptor 5-positive stem cells in the hair follicle. The onset of catagen is repressed by R-spondin2 injection, and the anagen phase persists. As a consequence, hair shafts grow longer. We conclude that R-spondin2 treatment activates hair follicle stem cells and therefore may have therapeutic potential to promote hair growth.

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“…Depending on the context, IDO limits immune activator mechanisms, thus preventing a detrimental immune activity, or induces immunosuppression (Hainz et al, 2007). The study performed by Kang (Kang et al, 2010) by carrying through 265 in the anagen phase: for example, the assessment of IGF1 mARN is being linked with hair shaft elongation after successful radiation therapy (Yoon et al, 2011). Taken together, these data suggest the fact that the increased levels of IGF1 mARN in our patients reflect the tendency of the hair follicle to restore itself.…”

Section: Discussionmentioning

confidence: 67%

Gene Expression of Indoleamine 2,3 Dioxygenase 1, Insulin-Growth Factor 1 and Red/IK Cytokine in Alopecia Areata

Şenilă¹,

Bălăcescu²,

Bălăcescu³

et al. 2014

Not Sci Biol

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Alopecia areata (AA) is a chronic, T-cell mediated autoimmune disease directed against the hair follicle, which partially evolves due to a loss of the immune privilege of the anagen hair follicle. The immune privilege is maintained by several factors, including a downregulation of MHC class I and II, local immunosupressants and expression of Fas ligand. The purpose of the study was to evaluate several factors involved in the collapse and restoration of the immune privilege. We investigated IDO1, IGF1 and red/IK gene expression in lesional and perilesionalscalp biopsies from alopecia areata patients. Seven paired punch-biopsies were taken from the active edge of alopecic plaque and from the perilesional scalp. Expression of IDO1, IGF1 and red/IK genes was performed by qRT-PCR. In lesional tissue, IGF1, IDO1 and red/IK genes showed an increase in the mRNA levels as compared with the perilesional scalp. By comparing the pairs of data for the investigated genes, IDO1was statistically upregulated in the lesional area. No significant differences were observed between the gene expression in mild or severe AA, from the lesional or perilesional areas.IDO1 mRNA expression was higher in patients with a relapse duration of less than 6 months as compared to patients with a relapse duration of more than 6 months; levels of IGF1 and red/IK mRNA are increased in lesionals compared to perilesional scalp area.

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Induction of Hair Growth by Insulin-Like Growth Factor-1 in 1,763 MHz Radiofrequency-Irradiated Hair Follicle Cells

Cited by 35 publications

References 40 publications

Review of Hair Follicle Dermal Papilla cells asin vitroscreening model for hair growth

Review of Hair Follicle Dermal Papilla cells asin vitroscreening model for hair growth

Activating Hair Follicle Stem Cells via R-spondin2 to Stimulate Hair Growth

Gene Expression of Indoleamine 2,3 Dioxygenase 1, Insulin-Growth Factor 1 and Red/IK Cytokine in Alopecia Areata

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