Induction of growth arrest by miR‐542‐3p that targets survivin

Yoon, Sena; Choi, Young‐Chul; Lee, Suman; Jeong, Yongsu; Yoon, Jaeseung; Baek, Kwanghee

doi:10.1016/j.febslet.2010.08.025

Cited by 63 publications

(65 citation statements)

References 20 publications

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“…A previous study showed that miR-542-3p was downregulated in matched ectopic endometrium compared to eutopic and normal endometrium (NE), implicating it in the pathogenesis of endometriosis (Toloubeydokhti et al, 2008). More recently, miR-542-3p was shown to target survivin and inhibit proliferation by inducing cell cycle arrest, suggesting a potential role for miR-542-3p in control of human cancer growth (Yoon et al, 2010). However, survivin is an evolutionarily non-conserved target of miR-542-3p, and it did not serve as a target in c-Srctransformed mouse embryonic fibroblasts (Supplementary Figure S2).…”

Section: Discussionmentioning

confidence: 99%

“…A previous study used a bioinformatic search (TargetScan) and a microarray analysis to identify the potential miR-542-3p target genes (Yoon et al, 2010). Among the predicted targets, survivin, a member of the inhibitor of apoptosis family, was shown to be a direct target of miR-542-3p in a human cancer cell line.…”

Section: Ilk Is a Conserved Target Of Mir-542-3pmentioning

confidence: 99%

“…To further evaluate the contribution of other miRNAs to c-Src transformation, we focused our analysis on miR-542-3p, whose function is as yet poorly characterized, although its potential tumor-suppressive role has been observed in a human cancer cell line (Yoon et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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MicroRNA-mediated upregulation of integrin-linked kinase promotes Src-induced tumor progression

et al. 2011

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The tyrosine kinase c-Src is upregulated in various human cancers; however, the molecular mechanisms underlying c-Src-mediated tumor progression remain unclear. Here we show that downregulation of microRNA (miR)-542-3p is tightly associated with tumor progression via c-Src-related oncogenic pathways. In c-Src-transformed fibroblasts and human cancer cells that overexpress c-Src, miR-542-3p is substantially downregulated, and the ectopic expression of miR-542-3p suppresses tumor growth. We identified the integrin-linked kinase (ILK) as a conserved target of miR-542-3p. ILK upregulation promotes cell adhesion and invasion by activating the integrin-focal adhesion kinase (FAK)/c-Src pathway, and can also contribute to tumor growth via the AKT and glycogen synthase kinase 3b pathways. MiR-542-3p expression is downregulated by the activation of c-Src-related signaling molecules, including epidermal growth factor receptor, K-Ras and Ras/ Raf/mitogen-activated protein kinase/extracellular signalregulated kinase. In human colon cancer tissues, downregulation of miR-542-3p is significantly correlated with the upregulation of c-Src and ILK. Our results suggest that the novel c-Src-miR-542-3p-ILK-FAK circuit plays a crucial role in controlling tumor progression.

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Section: Discussionmentioning

confidence: 99%

Section: Ilk Is a Conserved Target Of Mir-542-3pmentioning

confidence: 99%

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MicroRNA-mediated upregulation of integrin-linked kinase promotes Src-induced tumor progression

et al. 2011

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“…Aberrant expression of microRNAs has been identified to play roles of oncogenes or suppressors in various human cancers (19 -21), showing promising therapeutic potential for anticancer strategies (22,23). It has been reported that miR-542-3p, which is located in Xq26.3, is down-regulated in non-small cell lung cancer and breast cancer and directly targets survivin or angiopoietin-2, respectively, leading to growth arrest and angiogenesis inhibition (24,25). In the current study, we report that in astrocytoma down-regulation of miR-542-3p was significantly associated with histopathological grading and poor patient prognosis of the disease.…”

mentioning

confidence: 99%

MicroRNA-542-3p Suppresses Tumor Cell Invasion via Targeting AKT Pathway in Human Astrocytoma

Cai

Zhao

Zhang

et al. 2015

Journal of Biological Chemistry

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Background: MicroRNAs play important roles in regulating AKT pathway. Results: miR-542-3p suppresses glioblastoma cell invasion through directly inhibiting AKT1, ILK, and PIK3R1. Conclusion: miR-542-3p down-regulation contributes to aberrant activation of the AKT signaling, and miR-542-3p acts as a negative regulator in astrocytoma progression. Significance: Learning how miRNAs participate in AKT pathway is crucial for understanding its regulators and cancer therapy.

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“…As miR-542-3p has been proposed and validated to target Table 6 Myometrial micro-RNAs (miRNAs), their expression regulation, proposed function, and transcriptional targets. The role of micro-RNAs in the female reproductive tract survivin and suppress cell growth (Yoon et al 2010), the potential role of this miRNA in the pathogenesis of leiomyomas is unclear at this time. miR-498 has been proposed to target ZEB2 (based on upon TargetScan analysis).…”

Section: Uterus: Myometriummentioning

confidence: 99%

The role of micro-RNAs in the female reproductive tract

Nothnick

2012

Reproduction

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Proper development and function of the female reproductive tract are essential for successful reproduction. Regulation of the differentiated functions of the organs that make up the female reproductive tract is well established to occur at multiple levels including transcription, translation, and posttranslational modifications. Micro-RNA (miRNA)-mediated posttranscriptional gene regulation has emerged as a fundamental mechanism controlling normal tissue development and function. Emerging evidence indicates that miRNAs are expressed within the organs of the female reproductive tract where they function to regulate cellular pathways necessary for proper function of these organs. In this review, the functional significance of miRNAs in the development and function of the organs of the female reproductive tract is discussed. Initial discussion focuses on the role of miRNAs in the development of the organs of the female reproductive tract highlighting recent studies that clearly demonstrate that mice with disrupted Dicer1 expression are sterile, fail to develop uterine glands, and have muted estrogen responsiveness. Next, emphasis moves to discussion on our current knowledge on the characterization of miRNA expression in each of the organs of the female reproductive tract. When possible, information is presented and discussed with respect to regulation, function, and/or functional targets of these miRNA within each specific organ of the female reproductive tract.

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Induction of growth arrest by miR‐542‐3p that targets survivin

Cited by 63 publications

References 20 publications

MicroRNA-mediated upregulation of integrin-linked kinase promotes Src-induced tumor progression

MicroRNA-mediated upregulation of integrin-linked kinase promotes Src-induced tumor progression

MicroRNA-542-3p Suppresses Tumor Cell Invasion via Targeting AKT Pathway in Human Astrocytoma

The role of micro-RNAs in the female reproductive tract

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