Induction of Glutathione S-transferase Activity in Triatoma infestans

Sívori, JL; Casabé, Norma; En, Zerba; Wood, E. J.

doi:10.1590/s0074-02761997000600013

Cited by 28 publications

(22 citation statements)

References 27 publications

(23 reference statements)

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“…Increased GR activity can elevate the GSH/GSSG ratio, which is required for AsA regeneration . As we know, GST can catalyze the detoxification of lipid peroxides and xenobiotics by conjugating them with GSH . Therefore, increased activities of SOD, CAT, APX, GR, and GST can keep a low level of ROS and prevent ROS toxicity and protect cells.…”

Section: Discussionmentioning

confidence: 99%

Cardiac oxidative damage in mice following exposure to nanoparticulate titanium dioxide

Sheng

Wang

Sang

et al. 2013

J Biomedical Materials Res

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Nanoparticulate titanium dioxide (nano-TiO2 ) is a widely used powerful nanoparticulate material with high stability, anticorrosion, and photocatalytic property. However, it is possible that during nano-TiO2 exposure, there may be negative effects on cardiovascular system in intoxicated mice. The present study was therefore undertaken to determine nano-TiO2 -induced oxidative stress and to determine whether nano-TiO2 intoxication alters the antioxidant system in the mouse heart exposed to 2.5, 5, and 10 mg/kg body weight nano-TiO2 for 90 consecutive days. The findings showed that long-term exposure to nano-TiO2 resulted in obvious titanium accumulation in heart, in turn led to sparse cardiac muscle fibers, inflammatory response, cell necrosis, and cardiac biochemical dysfunction. Nano-TiO2 exposure promoted remarkably reactive oxygen species production such as superoxide radicals, hydrogen peroxide, and increased malondialdehyde, carbonyl and 8-OHdG levels as degradation products of lipid, protein, and DNA peroxidation in heart. Furthermore, nano-TiO2 exposure attenuated the activities of antioxidative enzymes, such as superoxide dismutase, ascorbate peroxidase, glutathione reductase, glutathione-S-transferase, and levels of antioxidants including ascorbic acid, glutathione, and thiol in heart. Therefore, TiO2 NPs exposure may impair cardiovascular system in mice, and attention should be aroused on the application of nano-TiO2 and their potential long-term exposure effects especially on human beings.

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Section: Discussionmentioning

confidence: 99%

Cardiac oxidative damage in mice following exposure to nanoparticulate titanium dioxide

Sheng

Wang

Sang

et al. 2013

J Biomedical Materials Res

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“…Elevated levels of GSTs might play a protective role in Nilaparvata lugens , an insect species, following pyrethroid exposure [7]. GSTs can be induced not only by general inductive agent of this enzyme, but also by various insecticides [8,9]. In addition, GST gene expression levels have been shown to decrease in locusts when exposed to different concentrations of deltamethrin [10].…”

Section: Introductionmentioning

confidence: 99%

Identification and Characterization of Seven Glutathione S-Transferase Genes from Citrus Red Mite, Panonychus citri (McGregor)

Liao

Zhang

Niu

et al. 2013

IJMS

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The citrus red mite, Panonychus citri (McGregor), is a global citrus pest, and has developed severe resistance to several types of acaricides. However, the molecular mechanisms of resistance in this mite remain unknown. In this study, seven full-length cDNAs encoding glutathione S-transferases (GSTs) genes were identified and characterized in P. citri. The effects of pyridaben and fenpropathrin exposure on the expression of these genes were also investigated. Phylogenetic analysis revealed that the seven GSTs genes in P. citri cloned in this study belong to three different cytosolic classes, including four in mu, two in delta and one in zeta. Among these seven GSTs genes, the relative expression level of PcGSTm1 was significantly higher in adult than in the other life stages (egg, larvae and nymph). Compared with the control, the mRNA levels of the seven GST genes did not change significantly following exposure to pyridaben at LC10. However, RT-qPCR results showed that, when exposed to LC10 of fenpropathrin, six GSTs gene (PcGSTm1, PcGSTm3, PcGSTm4, PcGSTd1, PcGSTd2 and PcGSTz1) transcripts increased in a time-dependent manner. This is the first insight into the molecular characteristics of GSTs gene cDNAs in P. citri. The elevated GSTs gene transcripts following exposure to fenpropathrin might be one of the mechanisms involved in detoxification of this acaricide.

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“…Similarly, GST activities were shown to increase in Drosophila reared for more than seven generations on diet containing 0.3% phenol (Shen et al, 2003). On the other hand, numerous plant flavonoids and other phenolic compounds were shown to be potent inhibitors of GSTs in S. frugiperda and Triatoma infestans (Sivori et al, 1997;Yu and Abo-Elghar, 2000). It is currently not clear if this inhibition occurs at the transcriptional or post-transcriptional levels, and whether our observed up-regulation of three GSTs in B. tabaci can be related to a counter-resistant mechanism to enzymes inhibition.…”

Section: Energy Production and Conversion 23%mentioning

confidence: 98%

Insights into the transcriptomics of polyphagy: Bemisia tabaci adaptability to phenylpropanoids involves coordinated expression of defense and metabolic genes

Alon

Elbaz

Ben-Zvi

et al. 2012

Insect Biochemistry and Molecular Biology

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Induction of Glutathione S-transferase Activity in Triatoma infestans

Cited by 28 publications

References 27 publications

Cardiac oxidative damage in mice following exposure to nanoparticulate titanium dioxide

Cardiac oxidative damage in mice following exposure to nanoparticulate titanium dioxide

Identification and Characterization of Seven Glutathione S-Transferase Genes from Citrus Red Mite, Panonychus citri (McGregor)

Insights into the transcriptomics of polyphagy: Bemisia tabaci adaptability to phenylpropanoids involves coordinated expression of defense and metabolic genes

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