Induction of gene mutations by lectins of different origin and cytokine EMAP II in somatic mammalian cells in vitro

Abstract

In sti tute of mo lec u lar bi ol ogy and ge net ics NAS of Ukraine Academicain Zabolotnog str.,

Regulation of mutagenesis by exogenous biological factors in the eukaryotic cell systems

“…We used a number of the proteins, capable of revealing mutagenic and cytotoxic activities and causing the programmed death: àpoptosis. It has been shown that such different proteins as human hormone insulin and cytokine EMAP II and lectins of plant and animal origin induced gene mutations in somatic mammalian cells at early terms after their introduction [7,63,64]. Direct dependence of the induced mutagenic effect on the concentration of lectins in a wide range of doses was shown [63].…”